Effect of Artificial Endolymph Injection into the Cochlear Duct on Perilymph Potassium

耳蜗管人工内淋巴注射对外淋巴钾的影响

• 批准号: 16591714
• 负责人: KAKIGI Akinobu
• 金额: $ 2.18万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591714/
• 关键词: Meniere's disease; potassium ion; endolymphatic hydrops

The pathological feature of Meniere's disease is endolymphatic hydrops. However, the causes of symptoms during Meniere's attacks remain unclear. One hypothesis of the Meniere's attack is that endolymphatic hydrops causes perilymphatic potassium increase and the potassium has a toxic effect on the eighth nerve.^<1,2> The results from temporal bone histopathology of Meniere's disease that include the rupture of the Reissner's membrane support this hypothesis. If it is the case, high K^+ of endolymph should leak into scala vestibuli. The higher K^+ in scala vestibuli could propagate into scala tympani through the spiral ligament and, in apical regions, through the helicotrema. However, the cause of K^+ leakage from endolymph could occur not only from a rupture of the Reissner's membrane but also from a permeability change of the cochlear duct without rupture, suggested by observations that Reissner's membrane ruptures are not observed in all temporal bones following attacks. The purpose of this study is to investigate the relationship between endolymphatic hydrops and perilymphatic potassium under conditions without Reissner's membrane rupture.

梅尼埃病的病理特征是内淋巴积水。然而，梅尼埃发作期间症状的原因仍不清楚。梅尼埃病发作的一种假设是内淋巴积水导致外淋巴钾增加，而钾对第八神经具有毒性作用。^<1,2> 梅尼埃病颞骨组织病理学结果，包括赖斯纳膜支持破裂这个假设。如果是这样的话，内淋巴的高 K^+ 应该泄漏到前庭阶。前庭阶中较高的 K^+ 可以通过螺旋韧带传播到鼓阶，并且在顶端区域通过螺旋孔传播到鼓阶。然而，K^+从内淋巴漏出的原因不仅可能是由于赖斯纳膜的破裂，而且还可能是由于未破裂的耳蜗管的渗透性变化，通过观察发现，在以下所有颞骨中都没有观察到赖斯纳膜破裂。攻击。本研究的目的是探讨在无赖斯纳膜破裂的情况下内淋巴积水与外淋巴钾之间的关系。