A Nation-wide estimation of the cumulative incidence and disease burden of the rotavirus gastroenteritis

全国轮状病毒胃肠炎累积发病率和疾病负担的估计

• 批准号: 16590504
• 负责人: ARISAWA Kokichi
• 金额: $ 2.24万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590504/
• 关键词: Rotavirus; Gastroenteritis; Incidence rate; Meta-analysis; Vaccine; Intussusception; Epidemiology

(1)Estimation of annual incidence, age-specific incidence rate, and the cumulative risk of rotavirus gastroenteritis among children in Japan.Rotavirus gastroenteritis is a common childhood infection, but the exact morbidity of the disease is not well described in Japan. We aimed at estimating morbidity measures to determine the magnitude of rotavirus gastroenteritis. An estimate for acute infectious gastroenteritis of all causes, to which rotavirus gastroenteritis belongs, has been available since the enactment in 1999 of the Law concerning the Prevention of Infectious Diseases and Medical Care of Patients with Infectious Diseases. Using this estimate and another estimate for the detection proportion of rotavirus among outpatients with acute infectious gastroenteritis, we calculated the annual incidence, the age-specific annual incidence rate, and the cumulative risk by the age of 6 years for rotavirus gastroenteritis. The latter estimate was obtained by a meta-analysis of four indepen … More dent studies previously performed in Japan. According to our estimates, approximately 800,000 children in Japan under the age of 6 years visit pediatric practices or the outpatient department of hospitals because of rotavirus gastroenteritis at a rate of 11 cases/100 persons/year, and one in two children will visit pediatricians before they go to primary school. Such pediatrician visits most frequently occur at the age of 1 year (27 cases/100 persons/year). Thus, the magnitude of the burden of rotavirus disease among Japanese children is substantial.(2)A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period (1978-2002).The development of second-generation rotavirus vaccines requires knowledge of baseline incidence rates for intussusception in infants prior to vaccine introduction. To obtain such estimates we reviewed clinical records in a hospital that served as the major provider of paediatric beds in a local community in the northern part of Japan. During the 25-year period (1978-2002), there were 91 hospitalizations due to radiologically confirmed intussusception in children <5 years of age, of which 45% were <1 year of age. Assuming that all children with intussusception in the area had been admitted to this hospital, there were an average of 185 and 78 hospitalizations per 100000 person-years for children <1 year old and 5 years old respectively. There was period-to-period variability with no long-term secular trend in the incidence of intussusception. The incidence rate in Japan was among the highest thus far reported, providing further evidence of geographic variability. Less

(1)日本儿童轮状病毒胃肠炎的年发病率、年龄别发病率和累积风险的估计。轮状病毒胃肠炎是一种常见的儿童感染，但该病的确切发病率在日本尚不清楚。自颁布以来，已经可以估计轮状病毒胃肠炎所属的所有原因的急性传染性胃肠炎的发病率。根据1999年《传染病预防和传染病患者医疗法》中的规定，我们利用这一估计值和对急性传染性胃肠炎门诊患者中轮状病毒检出比例的另一估计值，计算了年发病率，即分年龄的年发病率。根据我们之前在日本进行的四项独立研究的荟萃分析，得出了轮状病毒胃肠炎的发病率和 6 岁时的累积风险。据估计，日本大约有 80 万名 6 岁以下儿童因轮状病毒胃肠炎前往儿科诊所或医院门诊部就诊，比率为每年 11 例/100 人，其中二分之一的儿童在就诊前会先去看儿科医生。此类儿科医生就诊最常见于 1 岁（27 例/100 人/年）。因此，日本儿童中轮状病毒疾病的负担程度为（2）据哨点医院 25 年（1978-2002 年）研究显示，日本肠套叠发病率很高。第二代轮状病毒疫苗的开发需要了解婴儿肠套叠的基线发病率。为了获得此类估计，我们查阅了一家医院 25 年来作为日本北部当地社区儿科床位主要提供者的临床记录。 （1978-2002年），有91例<5岁儿童因放射学确诊为肠套叠而住院，其中45%为<1岁，假设该地区所有肠套叠儿童都收治于该医院，平均每10万人年有185例和78例<1岁和5岁儿童住院治疗。肠套叠的发病率存在不同时期的差异，但没有长期趋势 日本是迄今为止报道的发病率最高的国家之一，这提供了地理差异的进一步证据。

项目成果

標準微生物学

标准微生物学

• 发表时间: 2009
• 作者: 木村 貴文;他;町島由章;薗田精昭;森直樹;薗田精昭;Naoki Mori;Sonoda Y;森 直樹
• 通讯作者: 森 直樹

医科細菌学第4版 国際感染症と公衆衛生.感染の疫学

医学细菌学第四版国际传染病和公共卫生感染流​​行病学。

• 发表时间: 2006
• 作者: J.Jiang;S.Suzuki;S.Tokudome et al.;有澤 孝吉
• 通讯作者: 有澤 孝吉

Estimation of annual incidence, age-specific incidence rate, and the cumulative risk of rotavirus gastroenteritis among children in Japan.

日本儿童轮状病毒胃肠炎的年发病率、年龄别发病率和累积风险估计。

• 发表时间: 2004
• 期刊: Japanese Journal of Infectious Diseases 57(4)
• 作者: Fukuda Y;Nakamura K;Takano T.;Suzuki Sadao;Yokoo M
• 通讯作者: Yokoo M

医科細菌学第4版(南江堂)

医学细菌学第4版（Nankodo）

• 发表时间: 2006
• 作者: S.Tokudome Masayo Kojima;S.Suzuki et al.;有澤 孝吉
• 通讯作者: 有澤 孝吉

Randomized controlled trial of swaddling versus massage in the management of excessive crying in infants with cerebral injuries.

襁褓与按摩治疗脑损伤婴儿过度哭泣的随机对照试验。

• 发表时间: 2004
• 期刊: Archives of Disease in Childhood 89(3)
• 作者: Fukuda Y;Nakao H;Imai H.;Mikami T.;Tokudome Shinkan;Mikami T;Tokudome Shinkan;Takamura N;鈴木貞夫;Ohgi S
• 通讯作者: Ohgi S