Utilization as Molecular Container of Layered Double Hydroxides for Vitamins

作为维生素层状双氢氧化物分子容器的用途

基本信息

批准号：
16550164
负责人：
NARITA Eiichi
金额：
$ 2.37万
依托单位：
Iwate University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

For the development of biocompatible and health supporting materials, we have studied on the utilization of layered double hydroxide (LDH) as ‘Molecular container'. In this study, the intercalation of vitamin C (L-ascorbic acid) and vitamin A acid (retinoic acid) into tree kinds of LDH was investigated, as well as the stability of these guest vitamins in LDH and the release of vitamins from the resulting composites.First, Mg-Al,Mg-Fe and Zn-Al LDHs were adopteted as host hydroxide layers. It was found the vitamin C was intercalated only in Mg-Al and Mg-Fe LDHs by the reconstruction method and only in Mg-Al and Zn-Al LDHs by the coprecipitation method. The intercalation isotherms were obtained in each cases and all the data was well-treated by the Freundlich adsorption equation. Moreover, vitamin A acid was also intercalated in Mg-Al LDH.On the other hand, there is two types of vitamin C, i.e.,reduced type and oxidized type, and only the former demonstrates the reducing and physiological functions. After the white light irradiation treatment or heat treatment of the resulting vitamin/LDH composites, the amount of reduced type vitamin C in the composite was found to be about two times compared to that of the naked one in the same condition. Then, 82〜97% vitamin C was released from the composites by the anion exchange with carbonate ion. In addition, vitamin A acid was also stabilized in the interlayer of Mg-Al LDH and easily released by the same anion exchange.In conclusion, LDH can be used as ‘molecular container' for vitamins.

为了开发生物相容性和健康支持材料，我们研究了利用层状双氢氧化物（LDH）作为“分子容器”。在这项研究中，维生素C（L-抗坏血酸）和维生素A酸（视黄酸）的嵌入。研究了LDH中客体维生素的稳定性以及所得复合材料中维生素的释放。首先，Mg-Al、Mg-Fe和Zn-Al采用LDHs作为主体氢氧化物层，通过重构法发现维生素C仅嵌入到Mg-Al和Mg-Fe LDHs中，并且通过共沉淀法仅嵌入到Mg-Al和Zn-Al LDHs中。在每种情况下获得的数据都通过 Freundlich 吸附方程进行了很好的处理。此外，维生素 A 酸也插入到 Mg-Al LDH 中。维生素C有还原型和氧化型两种，只有前者表现出还原性和生理功能，所得维生素/LDH复合物经过白光照射处理或热处理后，还原型维生素的量。结果发现，在相同条件下，复合材料中的维生素C大约是裸露维生素C的两倍。此外，通过与碳酸根离子的阴离子交换，复合材料中释放出82-97%的维生素C。 Mg-Al LDH的层间还稳定了一种酸，并且很容易通过相同的阴离子交换释放出来。综上所述，LDH可以用作维生素的“分子容器”。