Development of Novel "Nonamphiphilic" Polymeric Micelles

新型“非两亲性”聚合物胶束的开发

• 批准号: 16510086
• 负责人: YOSHIDA Eri
• 金额: $ 2.11万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16510086/
• 关键词: "Nonamphiphilic" polymers; Polymeric micelles; Spherical nanoparticles; Noncovalent bond cross-linking; Block copolymers; Random copolymers; Critical micelle concentration; Functional nanoparticles; 非両親媒性"高分子; ミセル形成; 超微粒子; ナノ染料分子; ナノ粒子化; 紫外線吸

We found novel micelle formation of "nonamphiphilic" polymers consisting entirely of solvophilic segments and developed new polymeric materials using the micelle formation. We prepared nonamphiphilic block copolymers and random copolymers having electron-donating groups at the side chains. The copolymers showed no self-assembly by themselves. The light scattering studies demonstrated that the copolymers formed spherical micelles with a nanoscale in the presence of additives which have an interaction or promote salt formation with the side groups of the copolymers. The size and aggregation numbers of the micelles were dependent on the molecular weight of the polymers, the functionality and structure of the additives, indicating that the size and aggregation numbers of the micelles could be controlled by these factors. We also explored the thermodynamics and kinetics of the micellization and determined the enthalpy and entropy of the micelle formation. Furthermore, we succeeded in preparing functional nanoparticles through the micelle formation of block copolymers with functional groups. The micellization of block copolymers with dye molecules and UV absorbents produced highly light-stable nanodyes.

我们发现了完全由溶无液片段组成的“非骨化”聚合物的新型胶束形成，并使用胶束形成开发了新的聚合物材料。我们制备了在侧链上具有电子基团的非抑制块共聚物和随机共聚物。共聚物本身并没有表现出自组装。光散射研究表明，在存在添加剂的情况下，共聚物与纳米级形成球形胶束，这些添加剂具有相互作用或促进与共聚物侧基的盐相互作用或促进盐的形成。胶束的大小和聚集数取决于聚合物的分子量，添加剂的功能和结构，表明胶束的大小和聚集数可以由这些因素控制。我们还探索了胶束化的热力学和动力学，并确定了胶束形成的焓和熵。此外，我们成功地通过与功能组的块共聚物的胶束形成制备了功能性纳米颗粒。与染料分子和紫外吸收剂的块共聚物的胶束化产生了高度轻稳定的纳米差。

项目成果

Thermodynamics and kinetics on micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene by α, ω-Dia mine

α, ω-Dia 矿形成非两亲性聚(乙烯基苯酚)-嵌段-聚苯乙烯胶束的热力学和动力学

• 发表时间: 2005
• 期刊: Colloid Polym. Sci 284
• 作者: Eri Yoshida;Shinichi Itsuno
• 通讯作者: Shinichi Itsuno

Reversible Control of Miceillization Induced by Hydrogen Bond Cross-Linking for a Nonamphiphilic Diblock Copolymer with an α,ω-Diamine

非两亲性二嵌段共聚物与 α,ω-二胺的氢键交联诱导的胶束化的可逆控制

• 期刊: Polym.Adv.Technol. 印刷中
• 作者: E.Yoshida;M.Ohta;Y.Terada
• 通讯作者: Y.Terada

高分子集合体からなる球状微粒子及びその微粒子の製造方法

由聚合物聚集体制成的球形细颗粒及其制造方法

• 发表时间: 2006

Reversible Control of Micellization Induced by Hydrogen Bond Crosslinking for a Nonamphiphilic Diblock Copolymer with an a,ω-Diamine

非两亲性二嵌段共聚物与 a,ω-二胺的氢键交联诱导的胶束化的可逆控制

• 发表时间: 2005
• 期刊: Polym. Adv. Technol. 16
• 作者: E.Yoshida;M.Ohta;Y.Terada
• 通讯作者: Y.Terada

Preparation of light-stable micelles with azo dyes from a nonamphiphilic random block copolymer

非两亲性无规嵌段共聚物偶氮染料光稳定胶束的制备

• 发表时间: 2005
• 期刊: Colloid Polym. Sci. 283
• 作者: E.Yoshida;M.Ohta
• 通讯作者: M.Ohta