A research for establishing non-invasive circulatory monitoring using the index of cardiovascular coupling

利用心血管耦合指标建立无创循环监测的研究

基本信息

批准号：
14571457
负责人：
HAYASHI Kazuko
金额：
$ 2.62万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571457/
关键词：
Ventricular Arterial Coupling Ees Ea Transfer Function second order response 4-element model Augmentation Index Efficiency of ventricular ejection Ejection Fraction システム同定特性インピーダンスコンプライアンス末梢血管抵抗 Augmentation Index 脈波伝搬速度動

项目摘要

We compared Ees/Ea with other general circulatory monitoring, and made clear the significance of Ees/Ea as circulatory monitoring. In myocardial infarction group, Ees/Ea value was significantly smaller (0.87±0.07), in comparison with hypertension group (1.46±0.29) and healthy group (2.17±0.29). On the other hand, as for augmentation index and pulse wave velocity, the significant difference was not recognized between myocardial infarction group and hypertension group. Thus, it was suggested that the integrated cardiovascular function, which was not provided from other indexes, can be measured with present methods. Furthermore, Ees/Ea measured by the present method correlated with the ejection fraction measured by an echocardiography (R=0.79; RMSE=0.08). In addition, the normal Ees/Ea range measured by the present method, agreed to a reported range measured by conventional methods. In the child group, Ees/Ea was slightly larger than the adult group, although the significant difference was not observed. Thus, the Ees/Ea measurement by this calculation method is expected to become the superior index, which distinguishes the cardiovascular function. In a study of monitoring Ees/Ea from periphery radial arterial pressure, we used 4 elements (arterial compliance, peripheral resistance, aortic characteristic impedance, inertia) for arterial vascular system, and examined the nature of pressure transmitting by 4 elements. As a result, aortic waveform was estimated from radial arterial pressure with the model transfer function which satisfied the circulatory dynamics. This study was an important strategy to estimate aortic pressure waveform from periphery radial arterial pressure waveform under various circulatory dynamics, which is important for on-line estimation of cardiovascular performance.

我们将EES/EA与其他通用电路监视进行了比较，并清楚地表明了EES/EA作为电路监视的重要性。在心肌违规组中，与高血压组（1.46±0.29）和健康组（2.17±0.29）相比，EES/EA值明显较小（0.87±0.07）。另一方面，对于增强指数和脉搏波速度，心肌违规组和高血压组之间没有认识到显着差异。这就是建议可以使用当前方法来测量未从其他索引提供的综合心血管函数。此外，通过本方法测量的EES/EA与通过超声心动图测量的射血分数相关（r = 0.79； RMSE = 0.08）。此外，通过本方法测量的正常EES/EA范围同意通过常规方法测量的报告范围。在儿童组中，EES/EA比成人组略大，尽管没有观察到显着差异。这是预计通过这种计算方法的EES/EA测量将成为超级索引，从而区分了心血管功能。在一项针对外周径向动脉压监测EES/EA的研究中，我们用于动脉血管系统的4个元素（动脉依从性，外周抗性，主动脉特征阻抗，惯性），并检查了4个元素的压力传播的性质。结果，从径向动脉压的模型转移函数中估算了主动脉波形，从而满足电路动力学。这项研究是在各种电路动力学下从周围径向径向动脉压力波形估算主动脉压力波形的重要策略，这对于心血管性能的在线估计很重要。