The Optimum Tensile Strength in Rotator Cuff Repair in Rats

大鼠肩袖修复的最佳拉伸强度

基本信息

批准号：
14571356
负责人：
ITOI Eiji
金额：
$ 1.09万
依托单位：
Akita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

We performed this experimental study to clarify the optimum t ensile strength in rotator cuff repair. We used 160 SD rats/320 shoulders. On the right side, 2 mm of supraspinatus tendon defect was created, opposite side was sham operated as control. Rotator Cuffs were repaired 8 categories of initial tensile strength (0g, 50g, 100g, 150g, 200g, 250g, and 300g).Specimens were obtained, 3 days, 1 week, 3 weeks, and 6weeks after the operation. Muscle volume of the supraspinatus, minor axis of muscle fibers, cell number in collagen fiber, configuration of collagen fiber were measured histologically, and maximum load, cross sectional area of the time, and maximum stress were assessed biomechanically.The volume of supraspinatus decreased postoperatively. Significant difference was not fount between repaired groups and controls. Initial tensile strength in cuff repair was not influent to the Amyotrophy of supraspinatus. Increase of round cell in collagen fiber was observed and collagen fiber was disheveled in comparison with a group of control where the supraspinatus tendon retouched. In cases that initial tensile strength was small, disorder of collagen fiber was large at 3 weeks postoperatively. However thes e no difference as compared with controls 6 weeks after the repair. The capillary neogenesis revealed no difference compared with control. Maximal loads at the sixth week were largest in 200g group. Maximum load of this group was significant greater than 0g, 50g groups.In conclusion, existence of optimum tension in rotator cuff repair was suggested. In the present experiment, 200g neighborhood can be said to be optimal tension.

我们进行了这项实验研究，以阐明肩袖修复中的最佳T累钉强度。我们使用了160个SD大鼠/320肩膀。在右侧，产生了2毫米的上张肌腱缺陷，相反的一侧被用作对照。对肩袖修复了8类的初始拉伸强度（0G，50G，100G，150G，200G，250G和300G）。手术后3天，1周，3周和6周获得了超源。肌肉体积，肌肉纤维的次要轴，胶原纤维中的细胞数，胶原纤维的构型在组织学上测量，最大负载，时间的横截面面积和最大压力，并在生物力学上评估。。修复的组和对照组之间的显着差异并不是源头。袖带修复中的初始拉伸强度对上张植物的肌瘤没有影响。观察到胶原纤维中圆细胞的增加，与一组对照组相比，胶原蛋白纤维被散发着胶原蛋白纤维的增加。在最初的拉伸强度很小的情况下，术后3周的胶原蛋白纤维障碍很大。但是，与对照组相比，这是没有差异的。与对照相比，毛细血管新发生没有差异。第六周的最大负载在200克组中最大。该组的最大载荷大于0g，大于50G组。总而言之，提出了肩袖修复中最佳张力的存在。在本实验中，可以说200G社区是最佳张力。