Characteristics and standardization of cardiac function in elderly populations

老年人群心功能特点及标准化

• 批准号: 17591252
• 负责人: NAKAJIMA Kenichi
• 金额: $ 0.77万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591252/
• 关键词: Nuclear Medicine Study; Myocardial standards; Multi-center study; Standardization of SPECT; Cardiac function in the elderly population

The following works have been performed for the standardization of the cardiac function in the elderly population.1)In the first year of this project, a two-year working group was organized in the Japanese Society of Nuclear Medicine (JSNM). By the cooperation of the members from Nihon Medical University, Keio-Gijuku University, Hokkaido University, Kanazawa University, Toranomon Hospital, Toho University, myocardial standard data were accumulated. The projects were approved by the ethical committees in each institution. The data were transferred to the format of the workstation in the center office of Kanazawa University. During this study, we took contact with Dr. Germano (Cedars Sinai Medical Center, USA) and Dr. Garcia (Emory University), who are the developer of the commonly available myocardial perfusion quantification software. The collaboration worked effectively in the progress of this project.2)In the JSNM working group activity, which has been performed from November 2005 to … More October 2007, standard data of myocardial perfusion, fatty acid metabolism (1-123 BMIPP) and sympathetic imaging (1-123 MIBG) were generated. By the deadline of the grants-in-aid, we finished the standardization of myocardial perfusion map. The final report from JSNM working group will be published as a report from the JSNM activity.3)Myocardial phantoms were generated and the quantitative data for 1-123 radiopharmaceutical was validated. The data acquisition was performed with the standard phantom, and standardized for the different types of cameras. Multiple-window acquisition method for 1-123 radiopharmaceutical was the best practical choice for the reliable data.4)A multi-center study, J-ACCESS (Nishimura, Tsunehiko, Chief investigator) was the first prognostic study in Japan in the field of Nuclear Cardiology. Among 4670 patients data accumulated for the study, 268 subjects were selected as the low-risk population for coronary artery disease. When standard values were calculated with respect to left ventricular ejection fraction and volumes, significant differences were demonstrated between female and male, and also among different age groups. Importance of population specific standard was emphasized by this study. Less

为了老年人心功能的标准化，已经开展了以下工作。1）在该项目的第一年，日本核医学会（JSNM）合作组织了一个为期两年的工作组。来自日本医科大学、庆应义塾大学、北海道大学、金泽大学、虎之门医院、东邦大学的成员，积累了心肌标准数据，并得到了各机构伦理委员会的批准。在这项研究中，我们联系了 Germano 博士（美国 Cedars Sinai 医学中心）和 Garcia 博士（埃默里大学），他们是常用心肌的开发者。灌注定量软件的合作在该项目的进展中发挥了有效作用。2）在 2005 年 11 月至 2007 年 10 月进行的 JSNM 工作组活动中，获得了以下标准数据：心肌灌注、脂肪酸代谢（1-123 BMIPP）和交感神经成像（1-123 MIBG）已生成。在资助截止日期前，我们完成了心肌灌注图的标准化工作。小组将作为 JSNM 活动的报告发表。3) 生成心肌模型并验证 1-123 放射性药物的定量数据数据采集得到验证。使用标准体模进行，并针对 1-123 放射性药物的不同类型的相机进行标准化的多窗口采集方法是获得可靠数据的最佳实用选择。4）多中心研究，J-ACCESS（Nishimura，Tsunehiko）。首席研究员）是日本核心脏病学领域的第一项预后研究，该研究积累了 4670 名患者数据，其中 268 名受试者被选为冠状动脉低危人群。当计算左心室射血分数和容量的标准值时，女性和男性之间以及不同年龄组之间存在显着差异，该研究强调了特定人群标准的重要性。

项目成果

Risk stratification and guiding management in nuclear medicine.

核医学风险分层及指导管理。

• 发表时间: 2006
• 期刊: World J Nucl Med 5-Suppl 1
• 作者: Yamada M;Yamada M;Kenichi Nakajima
• 通讯作者: Kenichi Nakajima

心筋MIBG検査の定量評価とその標準化

心肌 MIBG 检测的定量评估和标准化

• 发表时间: 2006
• 期刊: 核医学画像診断 21・1
• 作者: Yamada;et al.;中嶋憲一
• 通讯作者: 中嶋憲一

Myocardial quantitative analysis with "cardioBull" (analysis of normal data)

使用“cardioBull”进行心肌定量分析（正常数据分析）

• 发表时间: 2006
• 期刊: Rad Fan 4・11
• 作者: Koichi Okuda;Kenichi Nakajima
• 通讯作者: Kenichi Nakajima

Risk stratification and guiding management in nuclear medicine

核医学风险分层及指导管理

• 发表时间: 2006
• 期刊: World Journal of Nuclear Medicine 5・Suppl 1
• 作者: Tanaka;S.;Yamada;M;Kitahara;S.;Higuchi;T.;Honda;K.;Kamijima;K;Yamada;M.;呉 勁;Kenichi Nakajima
• 通讯作者: Kenichi Nakajima

(In Japanese) Quantification and standardization of I-123 MIBG myocardial study

（日语）I-123 MIBG 心肌研究的量化和标准化

• 发表时间: 2006
• 期刊: Kakuigaku Gazo Shindan 21・1
• 作者: Yamada;M.;Takahashi;K.;Kurahashi;C.;Yamada;M;Akio Yoneyama et al.;Kenichi Nakajima
• 通讯作者: Kenichi Nakajima