Boron compound uptake augmentation to use for neutron capture therapy.

硼化合物吸收增强用于中子俘获疗法。

基本信息

批准号：
17591245
负责人：
YOSHIDA Fumiyo
金额：
$ 1.09万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591245/
关键词：
BNCT BSH BSO in vivo

项目摘要

Boron neutron capture therapy (BNCT) is a targeted radiation therapy using a boron (B^<10>) compound and thermal neutrons. Sodium borocaptate (BSH) is widly used for BNCT of brain tumor. We reported that BSH uptake was enhanced in combination with butionine sulfoximine (BSO) in vitro (Cancer Lett. 215 (2004) 61-67). In this study, we investigated influence of BSO on BSH distribution in vivo. 9L glicosarcoma cells were subcutaneously inoculated to right legs of Fisher 344 rats. After 2 weeks, the rats were divided into 3 groups, BSO+ group, BSO-group and untreated group (control). The rats were sacrificed at 3 hours, 6hours or 12 hours after injection, and samples of brain, blood, subcutaneous tumor, muscle, skin, liver and kidney were obtained. The results of the blood boron concentration were 55.2±15.0 μg/mg at 3 hours after injection, 20.2±14. μg/mg at 6 hours, 10.8 ±20.6 μg/mg in BSO+ group. On the other hands, in BSH only group, they were 8.1 ± 6.2 μg/rag, 3.4 ± 0.5 μg/mg, 1.3 ± 0.2 μg/mg, respectively. The boron concentration included in each tissues were in proportion to blood boron concentration.Since in vivo boron level was maintained with high concentration by BSO combination, we performed BNCT for the subcutaneous tumor which we made to the rats legs. As the result, a tumor reduced BSO+ group significantly in comparison with BSO-group.In conclusion, the uptake of BSH was enhanced in combination with BSO in vivo as well as in vitro.

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Yoshida F(+5 authors) Combination of boron and gadolinium compounds for neutron capture therapy. An in vitro study.

Yoshida F（5位作者）硼和钆化合物的组合用于中子捕获疗法。

DOI：
发表时间：
2005
期刊：
J.Exp.Clin.Cancer Res. 24
影响因子：
0
作者：
Matsumura A;Yamamoto T;Zhang T
通讯作者：
Zhang T

Matsumura A Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy.

Matsumura A 放疗后中脑幼年毛细胞星形细胞瘤的切除术。

DOI：
发表时间：
2006
期刊：
Pediatr.Neurosurg. 42
影响因子：
0
作者：
Tsuboi K;Matsuda W;Nakamura K;Takano S
通讯作者：
Takano S

Perfusion-weighted magnetic resonance imaging of the spinal cord in cervical spondylotic myelopathy.

脊髓型颈椎病脊髓的灌注加权磁共振成像。

DOI：
发表时间：
2006
期刊：
Neurol. Med. Chir. (Tokyo) 46・12
影响因子：
0
作者：
Uemura K;Matsumura A;Isobe T (+4 authors)
通讯作者：
Isobe T (+4 authors)

Combination of Boron and Gadolinium Compounds for Neutron Capture Therapy. An In Vitro Study.

用于中子捕获疗法的硼和钆化合物的组合。

DOI：
发表时间：
2005
期刊：
Clin.Cancer Res. 24
影响因子：
0
作者：
Matsumura A;Zhang T;Nakai K;Endo K;Kumada H;Yamamoto T;Yoshida F;Sakurai F;Yamamoto K;Nose T
通讯作者：
Nose T

Perfusion-weighted magnetic resonances imaging of the spinal cord in cervical spondylotic myelopathy.

脊髓型颈椎病脊髓的灌注加权磁共振成像。