Epidemiology of Myelodysplastic Syndromes in Atomic Bomb Survivors

原子弹爆炸幸存者骨髓增生异常综合征的流行病学

基本信息

批准号：
17590545
负责人：
IWANAGA Masako
金额：
$ 2.24万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590545/
关键词：
Myelodysplastic Syndromes Atomic Bomb Survivors Radiation Exposure Epidemiology Pre-Leukemia Cancer Registry Database

项目摘要

[Background] Myelodysplastic syndromes (MDS) are acquired clonal stem cell disorders characterized by ineffective hematopoiesis and a high risk of progression to leukemia. Etiologies of MDS are still unknown. So far, there is no large-scale epidemiological study for population exposed to radiation.[Aim] To investigate the association between radiation exposure and a risk of MDS in Atomic bomb survivors.[Methods] Overall MDS cases were retrospectively accumulated from five hospitals in Nagasaki City and then identified Atomic bomb survivors by linkage with the Database of Nagasaki Atomic Bomb Survivors in the Scientific Data Center at Nagasaki University. Disease confirmation was conducted with the microscopic examination of bone marrow smear and clinical data. In retrospective cohort analyses, we set a retrospective cohort of Atomic bomb survivors who were alive at 1980.1.1 but no MDS. In age-adjusted population analyses, we used official prefecture population statistics and then compared MDS incidence between Atomic bomb survivors and Non-Atomic bomb survivors.[Results] Up to now, we accumulated approximately 600 MDS cases diagnosed during 1970' to 2004, and identified around 200 cases who were Atomic bomb survivors. In retrospective cohort analyses, 162 MDS were identified among a cohort of 87496 survivors during 1980 to 2004 (crude incidence rate: 10.7 per 103 PY). Risk of MDS was high in male than female (RR=1.7), in survivors exposed within 1.5km from hypocenter than those over 3.0km (RR=4.3). Risk of subtypes of RAEB ＆ RAEB-t was high compared with subtypes of RA ＆ RARS among survivors exposed within 1.5km. In age-adjusted population analyses, crude incidence rate of MDS was higher in Atomic bomb survivors than Non-Atomic bomb survivors (crude incidence rate: 10.0 vs. 6.49 per 106 PY, RR=1.5).[Discussion] Results suggest a clear association between radiation exposure and a risk of MDS. Radiation dose analysis is needed to confirm this association.

[背景]骨髓增生性综合征（MDS）是获得的克隆干细胞疾病，其特征是无效的造血和高血症的高风险。 MD的病因仍然未知。到目前为止，还没有针对受到辐射的人群的大规模流行病学研究。长崎大学。通过对骨髓涂片和临床数据的显微镜检查进行疾病确认。在回顾性队列分析中，我们设置了一个回顾性的原子弹幸存者，他们在1980.1.1还活着但没有MDS。经过年龄调整的人群分析，我们使用了官方的公平人口统计数据，然后比较了原子弹幸存者和非原子炸弹幸存者之间的MDS发病率。[结果]到目前为止，我们在1970年至2004年期间诊断出了大约600例MDS病例，并确定了大约200例原子炸弹炸弹幸存者。在回顾性队列分析中，在1980年至2004年期间，在87496个冲浪者的队列中鉴定了162个MDS（原始发病率：103 PY）。男性的MD风险高于女性（RR = 1.7），在距HypoCenter 1.5公里以内的冲浪者中，超过3.0公里以内的冲浪者（RR = 4.3）。与1.5公里以内的RA和RARS亚型相比，RAEB和RAEB-T亚型的风险很高。在年龄调整后的人群分析中，原子弹冲浪者的MD的原始发病率高于非原子炸弹冲浪者（粗炸弹冲浪者：10.0 vs. 6.49每106 PY，RR = 1.5）。需要辐射剂量分析以确认这种关联。