Cost and benefit of the genetic diagnosis for diabetes mellitus as a screening test.

糖尿病基因诊断作为筛查测试的成本和效益。

• 批准号: 17590450
• 负责人: OHSAWA Isao
• 金额: $ 0.83万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590450/
• 关键词: diabetes mellitus; genetic diagnosis; simulation model; decision analysis

Several diabetes susceptibility genes have been identified recently and expected to be used as screening tests for diabetes and/or diabetic complications.1.A Markov decision analytic model (computerized simulation model) of diabetes mellitus was constructed to evaluate the health implications of examining gene profiles as one of the screening tests for diabetes. The model incorporated the likelihood of developing diabetes and/or diabetic complications, costs, survival year and quality of life. Because of scarce published literature about the health benefits of genetic diagnosis and the weakness of the model structure itself, the simulation process needs further amelioration to accomplish the purpose.2.Through MEDLINE and Japna Centra Revuo Medicina (Ichushi) searches, we retrieved and reviewed English-language and Japanese-language articles about the genetic predisposition to diabetes mellitus, the effectiveness of gene profile examination on health benefits, and the decision and economical analyses of the genetic diagnosis. A lot of articles have dealt with the genetic problems through biological and molecular techniques. But scarce evidence has been reported about the health benefits of the genetic tests for lifestyle related disease such as diabetes mellitus. Some kinds of genetic profile examinations have already been innovated in diabetes fields. Health benefits of genetic diagnosis of diabetes remains to be investigated from several viewpoints such as quality of life, bioethics, and health economics.

最近已鉴定出几种糖尿病易感基因，并有望用于糖尿病和/或糖尿病并发症的筛查测试。 1.构建糖尿病马尔可夫决策分析模型（计算机模拟模型），以评估检查基因谱对健康的影响作为糖尿病筛查测试之一。该模型纳入了患糖尿病和/或糖尿病并发症的可能性、费用、生存年限和生活质量。由于关于基因诊断对健康的益处的公开文献较少以及模型结构本身的弱点，模拟过程需要进一步改进以达到目的。 2.通过MEDLINE和Japna Centra Revuo Medicina (Ichushi)检索，我们检索并回顾了有关糖尿病遗传易感性、基因图谱检查对健康益处的有效性以及基因诊断的决策和经济分析的英文和日文文章。许多文章通过生物和分子技术讨论了遗传问题。但关于基因检测对糖尿病等生活方式相关疾病的健康益处的报道却很少。某些类型的基因谱检查已经在糖尿病领域进行了创新。糖尿病基因诊断的健康益处仍有待从生活质量、生物伦理学和健康经济学等多个角度进行研究。