Cost and benefit of the genetic diagnosis for diabetes mellitus as a screening test.

糖尿病基因诊断作为筛查测试的成本和效益。

• 批准号: 17590450
• 负责人: OHSAWA Isao
• 金额: $ 0.83万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590450/
• 关键词: diabetes mellitus; genetic diagnosis; simulation model; decision analysis

Several diabetes susceptibility genes have been identified recently and expected to be used as screening tests for diabetes and/or diabetic complications.1.A Markov decision analytic model (computerized simulation model) of diabetes mellitus was constructed to evaluate the health implications of examining gene profiles as one of the screening tests for diabetes. The model incorporated the likelihood of developing diabetes and/or diabetic complications, costs, survival year and quality of life. Because of scarce published literature about the health benefits of genetic diagnosis and the weakness of the model structure itself, the simulation process needs further amelioration to accomplish the purpose.2.Through MEDLINE and Japna Centra Revuo Medicina (Ichushi) searches, we retrieved and reviewed English-language and Japanese-language articles about the genetic predisposition to diabetes mellitus, the effectiveness of gene profile examination on health benefits, and the decision and economical analyses of the genetic diagnosis. A lot of articles have dealt with the genetic problems through biological and molecular techniques. But scarce evidence has been reported about the health benefits of the genetic tests for lifestyle related disease such as diabetes mellitus. Some kinds of genetic profile examinations have already been innovated in diabetes fields. Health benefits of genetic diagnosis of diabetes remains to be investigated from several viewpoints such as quality of life, bioethics, and health economics.

最近已经鉴定出了几种糖尿病易感性基因，并预计将用作糖尿病和/或糖尿病并发症的筛查测试。1.MarkovMarkov决策分析模型（计算机化模拟模型）构建了糖尿病的糖尿病的构建，以评估检查基因概况的健康含义，以检查基因概况作为糖尿病筛查测试之一。该模型结合了患糖尿病和/或糖尿病并发症，成本，生存年份和生活质量的可能性。由于关于遗传诊断的健康益处以及模型结构本身的弱点的稀缺文献，模拟过程需要进一步改善才能实现目的。2。Through Medline和Japna Centra Revuo Medicina（Ichushi）搜索，我们检索并审查了英语语言和日本语言对遗传疾病的疾病疗效，并审查了对糖尿病的疾病的益处，并审查了糖尿病的效率，并依次进行了疾病，并进行了研究。以及对遗传诊断的经济分析。许多文章通过生物学和分子技术处理了遗传问题。但是，已经有关于生活方式相关疾病（例如糖尿病）的基因检测的健康益处的稀缺证据。某些遗传概况检查已经在糖尿病领域进行了创新。糖尿病遗传诊断的健康益处从几种观点，例如生活质量，生物伦理学和健康经济学等观点仍有待研究。