Molecular epidemiology of radiation induced thyroid cancer

辐射诱发甲状腺癌的分子流行病学

基本信息

批准号：
17590330
负责人：
ITO Masahiro
金额：
$ 1.98万
依托单位：
National Hospital Organization Nagasaki Medical Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590330/
关键词：
thyroid cancer childhood radiation Chernobyl epidemiology BRAF 放射線発癌分子疫学

项目摘要

A large increase in thyroid carcinoma incidence among those exposed as children to the high levels of fallout from the nuclear accident at Chernobyl in 1986 has been reported. The Chernobyl Tissue Bank (CTB) is an internationally supported project and ensures that materials (frozen tissue, fixed tissue sections, extracted DNA/RNA and blood samples) are available for appropriate research studies. Up to date more over 2,500 cases have been registered, and the CTB holds DNA and RNA from more than 280 thyroid tumors from the patients younger than 19 at the time of the explosion.Although over 95% of the cancers are classified as papillary carcinomas in the population around Chernobyl following exposure to fallout, they vary in their morphology, ranging from a solid immature phenotype, to well differentiated tumors dominated by either papillary or follicular architecture. Some of the early reports on the thyroid carcinomas around Chernobyl suggested that the solid morphology, aggressiveness, … More and the apparently high frequency of RET/PTC3 rearrangements were indicative of radiogenic tumors. However, recent studies have shown that the morphological pattern of papillary carcinomas is changing with increasing latency. We showed that short latency is associated with solid morphology and significantly more invasive spread when compared to tumors with a longer latent period. In contrast, the type of differentiation is associated with age at exposure. Many reports have suggested that RET/PTC3 rearrangements are associated with the solid morphology seen in short latency tumors, while well diffrentiated papillary carcinomas more often show RET/PTC1 rearrangements. The frequency of BRAF mutation is low in post Chernobyl thyroid cancer and is similar to that observed in other studies of childhood thyroid papillary carcinoma, and this may be related to the age of the patient at diagnosis. More recent study revealed that the unexposed group of tumors from Ukraine and Russia were essentially identical morphologically to the exposed tumors from the same area. The tumors from Japanese children were significantly different from the tumors from around Chernobyl, whether exposed or unexposed, showing significantly more differentiation, more papillary differentiation. One possibility deserving serious consideration is the iodine content of the diet. Less

据报道，Chernobyl 1986年的核病患者的甲状腺癌大幅增长到了Chernobyl组织（CTB）的高水平影响。 DNA/RNA和血液样本可用于适当的研究。在暴露后，切尔诺贝利周围的人口的形成量，它们的形态从固体不成熟的表型到由乳头状或卵泡结构所主导的良好的分化肿瘤不等。 /ptc3指示乳头状的变化与潜伏期的变化。在简短的肿瘤中，llary癌显示了Chernobyl甲状腺癌后BRAF突变的RET/PTC1重排较低，而在儿童期的其他研究中，乳头状癌可能与诊断患者有关来自乌克兰和俄罗斯的肿瘤与来自同一儿童的肿瘤基本上相同。饮食。