The effect of estrogen on blood pressure regulation during psychological stress and its mechanism

雌激素对心理应激时血压调节的作用及其机制

• 批准号: 15590208
• 负责人: MORIMOTO Keiko
• 金额: $ 2.3万
• 依托单位: Nara Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590208/
• 关键词: psychological stress; estrogen; blood pressure; catecholamine; endothelial nitric oxide synthase; telemetry system; postmenopausal women; menstrual cycle; ノルエピネフリン; 4-hydrixy-2-nonenal; ハンドグリップ; 一酸化窒素; 心拍数; 末梢血管

We obtained the following results on the effect of estrogen on stress-induced pressor responses and its mechanism.(1)Estrogen attenuates pressor responses induced by psychological stresses through endothelial nitric oxide synthase(eNOS) overexpression in rats.Pressor response to the cage-switch stress tended to be suppressed in the female (F) group compared with the male (M) group in free moving rats using the telemetry system. Furthermore, these responses to the cage-switch and restraint stresses were attenuated significantly in the ovariectomized estrogen-treated (E) group compared with the placebo-treated (P) group. However, pretreatment of NOS inhibitor diminished the difference of the stress-induced pressor response between the P and E groups. Moreover, the expression of eNOS in the mesentery enhanced significantly in the E group compared with the M and P groups. These results suggest that estrogen attenuates psychological stress-induced pressor responses and the mesenteric eNOS overexpression could explain the mechanism for its effect in rats.(2)Pressor response to mental stress varies during menstrual cycle depending on plasma estradiol levels in women.The resting blood pressure(BP) was not different between the menstrual (M) and the pre-ovulatory (O) phases of menstrual cycle in young women(YW). The elevations of systolic BP(SBP) and diastolic BP(DBF) induced by the Color Word Test(CWT) were slightly, but not significantly attenuated in O-phase compared with M-phase. In addition, the resting plasma norepinephrine(NE) was higher in O-phase, and its CWT-induced elevation tended to be attenuated in O-phase. Furthermore, the resting DBF was higher in postmenopausal women(PM) than YW. The significant and immediate elevation of DBP during the CWT was greater in PM than in YW and continued until about 15 min of the recovery period. These findings suggest that estrogen may attenuate the DBP elevations induced by the mental stress in women.

关于雌激素对应激诱发的升压反应的影响及其机制，我们得到了以下结果：(1)雌激素通过内皮型一氧化氮合酶(eNOS)过表达来减弱大鼠心理应激诱发的升压反应。笼开关的升压反应在使用遥测系统的自由移动大鼠中，与雄性（M）组相比，雌性（F）组的压力往往受到抑制。此外，与安慰剂治疗组（P）相比，切除卵巢的雌激素治疗组（E）对笼子开关和约束应力的反应显着减弱。然而，NOS抑制剂的预处理减少了P组和E组之间应激诱导的升压反应的差异。此外，与M组和P组相比，E组肠系膜中eNOS的表达显着增强。这些结果表明，雌激素减弱了心理压力引起的升压反应，而肠系膜 eNOS 过度表达可以解释其在大鼠中的作用机制。(2)精神压力的升压反应在月经周期中有所不同，具体取决于女性血浆雌二醇水平。年轻女性（YW）月经周期（M）和排卵前（O）阶段的压力（BP）没有差异。色词测试（CWT）引起的收缩压（SBP）和舒张压（DBF）升高在O期较M期有轻微但不显着减弱。此外，静息血浆去甲肾上腺素（NE）在O相时较高，且CWT引起的其升高在O相时趋于减弱。此外，绝经后女性（PM）的静息 DBF 高于 YW。 CWT 期间 DBP 的立即显着升高在 PM 中高于 YW，并持续到恢复期约 15 分钟。这些发现表明，雌激素可能会减弱女性精神压力引起的舒张压升高。

项目成果

Estrogen replacement suppresses stress-ind uceci caraiovascuiar responses in ovanectomized rats.

雌激素替代可抑制卵巢切除大鼠应激诱发的血管反应。

• 发表时间: 2004
• 期刊: Am J Physiol Heart Circ Physiol. 287(5)
• 作者: Morimoto K;Kurahashi Y;Shintani-Ishida K;Kawamura N;Miyashita M;Uji M;Tan N;Yoshida
• 通讯作者: Yoshida

Estrogen replacement suppresses stress-induced cardiovascular

雌激素替代可抑制压力诱发的心血管疾病

• 发表时间: 2004
• 期刊: Am J Physiol Heart Circ Physiol. 287(5)
• 作者: Morimoto K;Kurahashi Y;Shintani-Ishida K;Kawamura N;Miyashita M;Uji M;Tan N;Yoshida K.
• 通讯作者: Yoshida K.