Development of novel multiple comparison method and decision tree method using resampling techniques and its applications to medical and pharmaceutical data.

使用重采样技术开发新型多重比较方法和决策树方法及其在医学和制药数据中的应用。

• 批准号: 15590042
• 负责人: TAKAGI Tatsuya
• 金额: $ 1.15万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590042/
• 关键词: Resampling method; Multiple Comparison; Bonferroni method; Computer intensive method; Bootstrap method; Pharmaceutical metric science; Pharmaceutical Information science

Last fiscal year, we developed novel more applicable algorithm of statistical multiple comparison, and the power of test of our method was revealed to be equal to or better than the traditional less applicable methods, such as Dunnett's test and Tukey's test. The results of our study were published in the Journal of Computer Aided Chemistry(vol.4, pp.27-34 (2003)). In this year, we tried to apply a resampling method for obtaining the significance of predictable variables used in decision trees, and this approach was succeeded. The main achievements in this year are as described below.1) A resampling technique, which is similar to bootstrap method, was adopted for the decision tree method in order to find significant predictable variables (attributes) : it was impossibly difficult to find the significance of attributes in the case of decision tree methods. Our technique is not only able to find such significance but also visualize the level of significance using some 3D graphs. This met … More hod was applied to the prediction of the prognosis of brain tumor patients and satisfied results were obtained. A part of our results was reported at the symposium at the Symposia of the 124th Annual Meeting of the Pharmaceutical Society of Japan (Osaka) organized by the head investigator (Tatsuya TAKAGI) of this research project and Kozo TAKAYAMA, and at the Conference of Chemometrics and Bioinformatics in Asia 2004 (Shanghai) by the head investigator (TAKAGI) of this research project as an invited speaker. After the conference, this report was published in the Journal of Computer Aided Chemistry (vol.5, pp.35-46 (2004)).2) Based on the results of the studies in the last fiscal year, we tried to write fast and parallel software of our novel multiple comparison method using resampling method and publish on WWW pages by CGI. This software was already published on the WWW page, http : //www.gen-info.osaka-u.ac.jp/testdocs/tomocom/, with the manual of this software, http : //www.gen-info.osaka-u.ac.jp/testdocs/tomocom/tazyu.html, and the simple explanation of our algorithm, http : //www.phs.osaka-u.ac.jp /homepage/b015/research1.html. This software has been being used frequently. Less

上一个财政年度，我们开发了新颖的统​​计多重比较算法，并且揭示了我们方法的测试能力等于或更好，而不是传统不适用的方法，例如Dunnett的测试和Tukey的测试。我们的研究结果发表在《计算机辅助化学杂志》（第4卷，第27-34页（2003））上。在今年，我们试图采用一种重采样方法来获得决策树中使用的可预测变量的重要性，并成功。今年的主要成就如下所述。1）一种与Bootstrap方法相似的重采样技术，该技术被采用了决策树方法，以找到重要的可预测变量（属性）：在决策树方法的情况下，不可能找到属性的重要性。我们的技术不仅能够找到这种意义，而且还可以使用一些3D图可视化显着性水平。这匹配了……更多的HOD应用于脑肿瘤患者预后的预测，并获得了满足的结果。我们的一部分结果在日本制药学会（Osaka）第124届年度会议的研讨会上报道了这项研究项目和高山科佐山的首席研究员（tatsuya takagi），以及在Asia 2004（Shanghai aNanghai）的研究（TAKE）的研究（TAKE）研究员（TAKE）的研究（TAKE）研究员（TAKE）的研究（TAKE），这是该研究项目的研究项目和生物学家会议。会议结束后，该报告发表在《计算机辅助化学杂志》（第5卷，第35-46页（2004年））中。2）根据上一个财政年度的研究结果，我们试图使用重新采行方法编写新颖的多重比较方法的快速和平行软件，并在www页面上通过cgi撰写。 This software was already published on the WWW page, http: //www.gen-info.osaka-u.ac.jp/testdocs/tomocom/, with the manual of this software, http: //www.gen-info.osaka-u.ac.jp/testdocs/tomocom/tazyu.html, and the simple explanation of our算法，http：//www.phs.osaka-u.ac.jp/homepage/b015/research1.html。该软件经常使用。较少的

项目成果

統計解析の基礎 検定・推定・多重比較(実験データの解釈のために)

统计分析基础：测试、估计、多重比较（用于解释实验数据）

• 发表时间: 2004
• 期刊: CICSJ Bulletin 22(1)
• 作者: Tatsuya TAKAGI;et al.;高木 達也
• 通讯作者: 高木 達也

多重比較入門

多重比较简介

• 发表时间: 2005
• 期刊: CICSJ Bulletin 23(1)
• 作者: 高木 達也

A New Procedure of Validation for Binary Tree Models using Resampling Technique

使用重采样技术验证二叉树模型的新程序

• 发表时间: 2004
• 期刊: Journal of Computer Aided Chemistry Vol.5
• 作者: Tatsuya TAKAGI;Kousuke OKAMOTO;Masahiko YOKOTA Teruo YASUNAGA
• 通讯作者: Masahiko YOKOTA Teruo YASUNAGA

Introduction of Multiple Comparison Method

多重比较法介绍

• 发表时间: 2005
• 期刊: CICSJ Bull. vol.23(1)
• 作者: 高木 達也;Tatsuya TAKAGI
• 通讯作者: Tatsuya TAKAGI

A New Procedure of Validation for Binary Tree Models using Resampling Technique.

使用重采样技术验证二叉树模型的新程序。

• 发表时间: 2004
• 期刊: Journal of Computer Aided Chemistry 5
• 作者: Tatsuya TAKAGI;et al.
• 通讯作者: et al.