Control of Circadian Rhythms Based on The Oscillator Model.

基于振荡器模型的昼夜节律控制。

基本信息

批准号：
15560372
负责人：
NAKAO Mitsuyuki
金额：
$ 1.98万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15560372/
关键词：
time zone flight reentrainment phase oscillator model jet lag alertness shiftwork the suprachiasmatic nucleus sleep-waking rhythm 明暗サイクル休息-活動サイクル運動効果分離再同調

项目摘要

In this research, we planned to propose the strategy for minimizing the adaptation failure to the shiftwork and time zone flights by controlling the entrainment mechanisms of biological rhythms. The results are summarized as follows. (1)The model of the human circadian clock mechanisms was constructed, which consists of the oscillators I, II, and SW. In addition, the photo-responsiveness was introduced to the model (2)The behavior of biological rhythms under the time-zone flights was simulated by the model The simulations showed the plausible mechanisms underlying the diverse reentrainment patterns such as the orthodrimic, antidromic, and those by partition. That is, the magnitude of photic phase response and its sign when the subject is exposed to light, and the value of the interaction function from the oscillator I to II just after the exposure to light were shown to determine the reentrainment direction. (3)Exercise during waking time in the destination could prevent the circadian … More pacemakers from its reentrainment by partition In addition to the conditions (2), the value of the interaction function from the oscillator SW to II just after the exposure to light modifies the reentrainment direction. According to these knowledge, the favorable flight schedule from Tokyo to New York was proposed to accelerate the reentrainments and reduce the expected jet lag. (4)The phase oscillator does not have the amplitude. On the other hand, the thermoregulatory model of sleep control which we previously proposed has a merit to predict the behavior of alertness under the various circumstances. However, the model application was confined to the steady state where the phase relation between the pacemakers is not expected to significantly change. In other words, it is not applicable to the environments where light-dark and sleep-waking cycles dynamically change. Here, the integrated model was constructed by combining the phase oscillator model and the thermoregulatory model of sleep control This was realized by mapping the phases of the oscillators I and II to those of the oscillators X and Y. This integrated model provides the framework for predicting the behavior of alertness and biological rhythms under the diverse light-dark cycles and working schedules. Less

在这项研究中，我们平面了生物节奏的策略。模拟模拟显示出合理的机制Trainement方向。提议加速租金，并减少预期的喷射滞后。但是，模型的应用局限于状态，即在此期间的相关性。集成模型是通过结合相位振荡器模型和您的睡眠控制模型来构建的，振荡器I和振荡器X tegrated模型提供了预测在多样化的轻型羽毛和生物节奏下的行为的框架周期和工作时间表