Effect of endurance exercise at lactate threshold level on mental and physical health

乳酸阈值水平的耐力运动对身心健康的影响

基本信息

批准号：
15300219
负责人：
ATOMI Yoriko
金额：
$ 10.43万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

In this study, we examined the effect of lactate threshold (LT) exercise (running) (LT-run) on mental and physical health using mice and human. First, we designed to develop a measuring system for the respiratory gas exchange of running mice and to determine the physical capacity of two widely used mouse strains, C57BL/6J and BALB/c. The difference in physical capacity was detected between C57BL/6 and BALB/c. The measurement system may be useful in future research regarding genetic contribution to the determination of physical capacity. We investigated a change by a part in a brain of amine under and over LT, increased serotonin metabolic turnover in hippocampus was observed at under LT by a treadmill. Because stress hormones, such as glucocorticoid and catecholamines (adrenaline and noradrenaline), begin to increase from the level over lactate threshold, it may be said LT is the threshold that whole body stress response. Using voluntary exercise of mice, which if known to increase the adrenal sensitivity to circulating ACTH at the circadian peak, we explored molecular factor that may be involved in regulating the responsiveness of the adrenal gland. Only the StAR mRNA expression, which is a key enzyme for cholesterol synthesis in mitochondria, and also regulated by circadian rhythm, was altered in response to voluntary exercise. The StAR expression increased significantly, concomitantly with the increased adrenal sensitivity. We developed a method estimating LT to be able to use in field test. We found that the use of respiration frequency (RF) for the detection of LT is available for the estimation of a threshold to increase RF in place of LT by running speed increasing method using 100m running circle. More over, we are succeeded in getting a preliminary data suggesting an improvement of cognition after LT running for 30 min for human subjects.

在这项研究中，我们检查了使用小鼠和人类的乳酸阈值（LT）运动（LT）运动（LT）（LT-RUN）对心理和身体健康的影响。首先，我们旨在开发一种用于运行小鼠的呼吸气体交换的测量系统，并确定两种广泛使用的小鼠菌株的物理容量，即C57BL/6J和BALB/C。在C57BL/6和BALB/C之间检测到体力差。测量系统对于未来的研究对确定身体能力的遗传贡献可能很有用。我们调查了LT下胺和超过胺的大脑的一部分变化，跑步机在LT下观察到海马中的5-羟色胺代谢转换增加。由于诸如糖皮质激素和儿茶酚胺（肾上腺素和去甲肾上腺素）之类的应激激素从乳酸阈值上升的水平开始增加，因此可以说lt是整个体内应力反应的阈值。我们使用自愿运动的小鼠，如果已知会增加对昼夜峰值循环ACTH的肾上腺敏感性，我们探索了可能与调节肾上腺反应性有关的分子因子。只有恒星mRNA表达是线粒体中胆固醇合成的关键酶，并且也受昼夜节律调节，对自愿运动有所改变。随着肾上腺敏感性的增加，恒星表达显着增加。我们开发了一种估计LT的方法，以便能够在现场测试中使用。我们发现，使用呼吸频率（RF）用于检测LT，可用于估计阈值，以通过使用100m运行圆来增加速度提高方法来增加RF，以代替LT。更重要的是，我们成功地获得了初步数据，这表明LT在人类受试者中持续30分钟后的认知有所改善。