Effect of endurance exercise at lactate threshold level on mental and physical health

乳酸阈值水平的耐力运动对身心健康的影响

基本信息

批准号：
15300219
负责人：
ATOMI Yoriko
金额：
$ 10.43万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

In this study, we examined the effect of lactate threshold (LT) exercise (running) (LT-run) on mental and physical health using mice and human. First, we designed to develop a measuring system for the respiratory gas exchange of running mice and to determine the physical capacity of two widely used mouse strains, C57BL/6J and BALB/c. The difference in physical capacity was detected between C57BL/6 and BALB/c. The measurement system may be useful in future research regarding genetic contribution to the determination of physical capacity. We investigated a change by a part in a brain of amine under and over LT, increased serotonin metabolic turnover in hippocampus was observed at under LT by a treadmill. Because stress hormones, such as glucocorticoid and catecholamines (adrenaline and noradrenaline), begin to increase from the level over lactate threshold, it may be said LT is the threshold that whole body stress response. Using voluntary exercise of mice, which if known to increase the adrenal sensitivity to circulating ACTH at the circadian peak, we explored molecular factor that may be involved in regulating the responsiveness of the adrenal gland. Only the StAR mRNA expression, which is a key enzyme for cholesterol synthesis in mitochondria, and also regulated by circadian rhythm, was altered in response to voluntary exercise. The StAR expression increased significantly, concomitantly with the increased adrenal sensitivity. We developed a method estimating LT to be able to use in field test. We found that the use of respiration frequency (RF) for the detection of LT is available for the estimation of a threshold to increase RF in place of LT by running speed increasing method using 100m running circle. More over, we are succeeded in getting a preliminary data suggesting an improvement of cognition after LT running for 30 min for human subjects.

在这项研究中，我们利用小鼠和人类研究了乳酸阈值 (LT) 运动（跑步）（LT-run）对心理和身体健康的影响。首先，我们设计开发一种用于跑步小鼠呼吸气体交换的测量系统，并确定两种广泛使用的小鼠品系 C57BL/6J 和 BALB/c 的身体能力。在C57BL/6和BALB/c之间检测到物理容量的差异。该测量系统可能在未来有关遗传对身体能力确定的贡献的研究中有用。我们研究了 LT 下和超过 LT 时大脑中胺的一部分的变化，在 LT 下通过跑步机观察到海马中血清素代谢周转增加。由于糖皮质激素和儿茶酚胺（肾上腺素和去甲肾上腺素）等应激激素从超过乳酸阈值的水平开始增加，因此可以说LT是全身应激反应的阈值。通过小鼠的自愿运动（如果已知这会增加昼夜节律峰值时肾上腺对循环促肾上腺皮质激素的敏感性），我们探索了可能参与调节肾上腺反应性的分子因素。只有 StAR mRNA 的表达（它是线粒体中胆固醇合成的关键酶，也受昼夜节律调节）因自愿运动而发生改变。 StAR 表达显着增加，同时肾上腺敏感性增加。我们开发了一种能够在现场测试中使用的 LT 估计方法。我们发现，使用呼吸频率（RF）来检测 LT 可以用于估计阈值，通过使用 100m 跑步圈的跑步速度增加方法来增加 RF 来代替 LT。此外，我们成功获得了初步数据，表明人类受试者 LT 运行 30 分钟后认知能力有所改善。