High-resolution, high sensitivity SPECT for small animal imaging using ultra-cone-beam collimators

使用超锥束准直器对小动物进行高分辨率、高灵敏度 SPECT 成像

基本信息

  • 批准号:
    13557073
  • 负责人:
  • 金额:
    $ 5.95万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2003
  • 项目状态:
    已结题

项目摘要

We have designed novel pinhole and converging collimators for cone-beam SPECT of small objects. Particularly, these collimators were designed to cope with ultrahigh energy gamma photons. Cone-beam collimators, including pinhole and converging collimators, magnify an acquired image using gamma cameras. Consequently, spatial resolution of the image is improved. For the pinhole collimator, the diameter of the knife-edge pinhole aperture was 1.3 mm and the acceptance angle was 1゜. The thickness of the lead shielding was 30 mm. In SPECT experiments, spatial resolution, expressed as full-width-at-half maximum (FWHM), was 2.4±0.4 and 3.2±0.3 mm for Tc-99m and F-18 SPECT, respectively. In calculated simulations, as the pinhole-object distance decreased, geometric sensitivity geometrically increased. However, as the pinhole-object distance decreased, field-of-view decreased linearly. SPECT of a rat using Tc-99m and F-l8 enabled successful in vivo visualization of the myocardium. The converging … More collimator had a focal length of 200 mm, a hole length of 110 mm at the center and a hole diameter of 1.5 mm. Magnification was 1.9 times at a source-to-collimator distance of 10 mm. Planar spatial resolution was 1.7±0.2 mm and 2.8±0.8 mm (FWHM) for Tc-99m and F-18, respectively. A small myocardial phantom was clearly visualized by both Tc-99m and F-18 SPECT. Thus, we have demonstrated that high-resolution SPECT images can be acquired at ultra-high energy using our cone-beam collimators. Moreover, the most remarkable feature of our converging collimators is applicability to conventional rotating gamma camera SPECT systems. In addition, we have evaluated the spatial resolution of a commercial converging collimator which had a very short focal length (200 mm). The spatial resolution of the converging collimator was superior to that of the parallel-hole collimator. Thyroid scintigraphy using the commercial converging collimator better visualized cold lesions than the parallel-hole collimator. Less
我们已经为小物体的锥形梁设计设计了新颖的针孔和收敛的准仪。特别是,这些准直仪旨在应对超高的能量伽马照片。锥形梁准直仪,包括针孔和收敛准直仪,使用伽马相机放大了获得的图像。因此,图像的空间分辨率得到改善。对于针孔的准仪,刀边孔的直径为1.3 mm,接受角度为1゜。铅屏蔽的厚度为30毫米。在SPECT实验中,TC-99M和F-18 SPECT的空间分辨率分别为2.4±0.4和3.2±0.3 mm。在计算的模拟中,随着针孔 - 对象距离的降低,几何灵敏度几何增加。但是,随着针孔 - 对象距离的降低,视野线性降低。使用TC-99M和F-L8大鼠的SPECT使心肌的体内可视化成功。收敛的…更多的准二聚体的焦距为200 mm,中心的孔长度为110毫米,直径为1.5 mm。在源到仪表仪的距离为10 mm处的放大倍数为1.9倍。 TC-99M和F-18的平面空间分辨率分别为1.7±0.2 mm和2.8±0.8 mm(FWHM)。 TC-99M和F-18 SPECT清楚地看到了一个小的心肌幻影。这就是我们已经证明,可以使用我们的锥形束准直仪以超高的能量获取高分辨率SPECT图像。此外,我们收敛的准直仪的最显着特征是适用于常规的旋转伽马摄像头系统。此外,我们评估了商业收敛准直仪的空间分辨率,该准直仪的焦距非常短(200 mm)。收敛准直仪的空间分辨率优于平行孔准直仪的空间分辨率。甲状腺闪烁显像是使用商业收敛的准直仪比平行孔准直仪更好的可视化感冒病变。较少的

项目成果

期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Naoki Kubo: "An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc."International Congress Series. 1264. 275-279 (2004)
Naoki Kubo:“18F 和 99mTc 双同位素研究中用于小动物成像的超高能准直器。”国际大会系列。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
日本放射線技術学会核医学分科会 久保直樹(共著): "SPECT画像技術の基礎"日本放射線技術学会出版委員会. 29-35 (2001)
日本放射线技术学会核医学小组委员会久保直树(合著者):“SPECT成像技术的基础”日本放射线技术学会出版委员会29-35(2001)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Naoki Kubo: "A newly designed pinhole collimator for small animal SPECT in dual-isotope study of positron and gamma emitters."JOURNAL OF NUCLEAR MEDICINE. 44(5). 524 Suppl. S (2003)
Naoki Kubo:“一种新设计的针孔准直器,用于正电子和伽马发射体双同位素研究中的小动物 SPECT。”核医学杂志。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Naoki Kubo: "A newly designed pinhole collimator far small animal SPECT in dual-isotope study of positron and gamma emitters."JOURNAL OF NUCLEAR MEDICINE. 44(5). 524(Suppl.S) (2003)
Naoki Kubo:“一种新设计的针孔准直器远小动物 SPECT 用于正电子和伽马发射体的双同位素研究。”核医学杂志。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Naoki Kubo: "Evaluation of a digital scintillator-photodiode camera with a converging collimator for high-resolution imaging."JOURNAL OF NUCLEAR MEDICINE. 44(5). 1010 Suppl. S (2003)
Naoki Kubo:“评估带有会聚准直器的数字闪烁体光电二极管相机,以实现高分辨率成像。”核医学杂志。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

KUBO Naoki其他文献

Superconductivity in Ag<i><sub>x</sub></i>TaS<sub>2</sub> single crystals with stage structure obtained via proton-driven ion introduction
质子驱动离子引入阶梯结构Ag<i><sub>x</sub></i>TaS<sub>2</sub>单晶的超导性
  • DOI:
    10.2109/jcersj2.18148
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    1.1
  • 作者:
    FUJIOKA Masaya;KUBO Naoki;NAGAO Masanori;MSISKA Robin;SHIRAKAWA Naoki;DEMURA Satoshi;SAKATA Hideaki;KAIJU Hideo;NISHII Junji
  • 通讯作者:
    NISHII Junji

KUBO Naoki的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('KUBO Naoki', 18)}}的其他基金

Improved input-function quantification in a noninvasive measurement using medical tomography
使用医学断层扫描改进无创测量中的输入函数量化
  • 批准号:
    23602001
  • 财政年份:
    2011
  • 资助金额:
    $ 5.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Improvement of Quantification in PET and Development of a Noninvasive Blood Radioactivity Monitor
PET 定量技术的改进和无创血液放射性监测仪的开发
  • 批准号:
    19591394
  • 财政年份:
    2007
  • 资助金额:
    $ 5.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Development of new technology for neutron imaging using multi pinhole collimator
多针孔准直器中子成像新技术的开发
  • 批准号:
    16K13729
  • 财政年份:
    2016
  • 资助金额:
    $ 5.95万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of fluorescent X-ray computed tomography using multi pinhole collimator
使用多针孔准直器的荧光 X 射线计算机断层扫描的开发
  • 批准号:
    26750142
  • 财政年份:
    2014
  • 资助金额:
    $ 5.95万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Scintigraphic imaging system of micro-metastasis of lymph node with pinhole collimator
针孔准直器淋巴结微转移闪烁显像系统
  • 批准号:
    20592206
  • 财政年份:
    2008
  • 资助金额:
    $ 5.95万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of Ultra-high Resolution Single Photon Emission Computed Tomography(SPECT) Using Pinhole-Collimator
使用针孔准直器的超高分辨率单光子发射计算机断层扫描 (SPECT) 的开发
  • 批准号:
    04680235
  • 财政年份:
    1992
  • 资助金额:
    $ 5.95万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了