High-resolution, high sensitivity SPECT for small animal imaging using ultra-cone-beam collimators

使用超锥束准直器对小动物进行高分辨率、高灵敏度 SPECT 成像

• 批准号: 13557073
• 负责人: KUBO Naoki
• 金额: $ 5.95万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557073/
• 关键词: converging collimator; pinhole collimator; positron emitter; 超高エネルギーコリメータ; SPECT; 超高エネルギー; 高空間分解能; 画像評価; コーンビーム; 2核種同時収集; 小動物SPECT; Tc-99m放出核種; ポジトロン放出核種

We have designed novel pinhole and converging collimators for cone-beam SPECT of small objects. Particularly, these collimators were designed to cope with ultrahigh energy gamma photons. Cone-beam collimators, including pinhole and converging collimators, magnify an acquired image using gamma cameras. Consequently, spatial resolution of the image is improved. For the pinhole collimator, the diameter of the knife-edge pinhole aperture was 1.3 mm and the acceptance angle was 1゜. The thickness of the lead shielding was 30 mm. In SPECT experiments, spatial resolution, expressed as full-width-at-half maximum (FWHM), was 2.4±0.4 and 3.2±0.3 mm for Tc-99m and F-18 SPECT, respectively. In calculated simulations, as the pinhole-object distance decreased, geometric sensitivity geometrically increased. However, as the pinhole-object distance decreased, field-of-view decreased linearly. SPECT of a rat using Tc-99m and F-l8 enabled successful in vivo visualization of the myocardium. The converging … More collimator had a focal length of 200 mm, a hole length of 110 mm at the center and a hole diameter of 1.5 mm. Magnification was 1.9 times at a source-to-collimator distance of 10 mm. Planar spatial resolution was 1.7±0.2 mm and 2.8±0.8 mm (FWHM) for Tc-99m and F-18, respectively. A small myocardial phantom was clearly visualized by both Tc-99m and F-18 SPECT. Thus, we have demonstrated that high-resolution SPECT images can be acquired at ultra-high energy using our cone-beam collimators. Moreover, the most remarkable feature of our converging collimators is applicability to conventional rotating gamma camera SPECT systems. In addition, we have evaluated the spatial resolution of a commercial converging collimator which had a very short focal length (200 mm). The spatial resolution of the converging collimator was superior to that of the parallel-hole collimator. Thyroid scintigraphy using the commercial converging collimator better visualized cold lesions than the parallel-hole collimator. Less

我们为小物体的锥束 SPECT 设计了新型针孔和会聚准直器，特别是，这些准直器旨在应对超高能量伽马光子，包括针孔和会聚准直器，可使用伽马相机放大获取的图像。经测试，图像的空间分辨率得到了提高。对于针孔准直器，刀口针孔孔径的直径为1.3mm，接收角。铅屏蔽的厚度为 30 mm，在 SPECT 实验中，Tc-99m 和 F 的空间分辨率（FWHM）分别为 2.4±0.4 和 3.2±0.3 mm。 -18 SPECT，分别在计算模拟中，随着针孔-物体距离的减小，几何灵敏度呈几何级数增加。使用 Tc-99m 和 F-l8 的大鼠 SPECT 成功实现了心肌的体内可视化。会聚准直器的焦距为 200 毫米，孔长为 110 毫米。中心和孔径为 1.5 毫米，放大倍数为 1.9 倍，源到准直器距离为 1.7±0.2。 Tc-99m 和 F-18 分别为 2.8±0.8 mm (FWHM) 和 Tc-99m 和 F-18 SPECT 清晰可见。使用我们的锥束准直器可在超高能量下获取。此外，我们的会聚准直器最显着的特点是适用于传统的旋转伽马相机 SPECT。此外，我们还评估了焦距非常短（200 毫米）的商用会聚准直器的空间分辨率优于使用甲状腺闪烁扫描仪的平行孔准直器。商用会聚准直器比平行孔准直器能更好地显示冷病灶。

项目成果

Naoki Kubo: "An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc."International Congress Series. 1264. 275-279 (2004)

Naoki Kubo：“18F 和 99mTc 双同位素研究中用于小动物成像的超高能准直器。”国际大会系列。

日本放射線技術学会核医学分科会 久保直樹(共著): "SPECT画像技術の基礎"日本放射線技術学会出版委員会. 29-35 (2001)

日本放射线技术学会核医学小组委员会久保直树（合著者）：“SPECT成像技术的基础”日本放射线技术学会出版委员会29-35（2001）。

Naoki Kubo: "A newly designed pinhole collimator for small animal SPECT in dual-isotope study of positron and gamma emitters."JOURNAL OF NUCLEAR MEDICINE. 44(5). 524 Suppl. S (2003)

Naoki Kubo：“一种新设计的针孔准直器，用于正电子和伽马发射体双同位素研究中的小动物 SPECT。”核医学杂志。

Naoki Kubo: "A newly designed pinhole collimator far small animal SPECT in dual-isotope study of positron and gamma emitters."JOURNAL OF NUCLEAR MEDICINE. 44(5). 524(Suppl.S) (2003)

Naoki Kubo：“一种新设计的针孔准直器远小动物 SPECT 用于正电子和伽马发射体的双同位素研究。”核医学杂志。

Naoki Kubo: "Evaluation of a digital scintillator-photodiode camera with a converging collimator for high-resolution imaging."JOURNAL OF NUCLEAR MEDICINE. 44(5). 1010 Suppl. S (2003)

Naoki Kubo：“评估带有会聚准直器的数字闪烁体光电二极管相机，以实现高分辨率成像。”核医学杂志。