Damage Analysis by Elongation of Blood Vessels

通过血管伸长进行损伤分析

基本信息

批准号：
13557035
负责人：
FUNAYAMA Masato
金额：
$ 3.14万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557035/
关键词：
injury of vessels disruption of vessels elongation of vessels aorta trauma stress strain 血管変性加速度動物実験動脈張力変位量

项目摘要

The device was designed to analyze the damages to blood vessels while elongating beyond its physiological limits. It consists of a stepping motor, pulse generator, leaf spring and data transmission. Elongating speed is controlled by either constant or accelerated. A non-traumatic grasping forceps was used to fix at each end of a vessel. For purpose of data collections of uniform samples, rectangular materials (10 x 4 mm) of aorta of rabbits were trimmed with the longitudinal or horizontal direction of it, and set and pulled. Strain-stress curves during vessel elongations showed a certain pattern even though they appeared to have a large degree of dispersions. The values of stress increased slowly after starting elongation (the first stage), and then increases of stress raised sharply (the second stage). After reaching a peak, the values of stress decreased (the third stage). The first stage would show the normal physiological phase of extension and shrinkage that normal vessels have, and the second stage would show own characteristics of each vessel. And the third stage was destructive one. After improper materials were eliminated, the values of stress and strain were statistically compared between materials of longitudinal and horizontal direction. The similar tendency was obtained from a fixed speed (40mm/mm) and an acceleration (0.000467m/s^2). In this study, we established how to analyze disruption of the ^*large-sized arteries while elongating, however, in case of the median-sized arteries like vertebral arteries, further improvement of the grasping pars is needed.

该设备旨在分析血管在超出其生理极限时的损伤情况。它由步进电机、脉冲发生器、板簧和数据传输器组成。拉伸速度可以恒定或加速控制。使用非创伤性抓钳固定血管的每一端。为了收集均匀样本的数据，将兔子主动脉的矩形材料（10 x 4 mm）沿其纵向或水平方向修剪，并固定和牵拉。血管伸长过程中的应变-应力曲线显示出一定的模式，尽管它们似乎具有很大程度的分散性。开始伸长后应力值缓慢增加（第一阶段），然后应力增加急剧增加（第二阶段）。达到峰值后，压力值下降（第三阶段）。第一阶段将显示正常血管具有的扩张和收缩的正常生理阶段，第二阶段将显示每个血管自身的特征。第三阶段是破坏性的阶段。排除不合适的材料后，统计比较材料纵向和横向的应力和应变值。从固定速度（40mm/mm）和加速度（0.000467m/s^2）获得类似的趋势。在这项研究中，我们建立了如何分析拉长时大型动脉的破坏，但是，对于椎动脉等中等尺寸的动脉，需要进一步改进抓握部位。