Confirmation of Safety and Long-term Durability of CCC (Chitosan-Copper Complex) as An Environmental Friendly Wood Preservatives

确认 CCC（壳聚糖-铜复合物）作为环保型木材防腐剂的安全性和长期耐久性

• 批准号: 12556028
• 负责人: FURUKAWA Ikuo
• 金额: $ 2.43万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12556028/
• 关键词: Chitosan-Copper-Complex; Safety; Long-term Durability; Intercellular Space Network; Microdistribution of Copper elements; Anti-termite attack; Anti-fungal attack; 安全性; 急性経口毒性試験; 目一次刺激性試験; 皮膚一次刺激性試験; 皮膚感作性試験; 復帰突然変異試験; CCC(キトサン銅複合体); 長期劣化耐久性; Chitosan-Copper-Complex; Safety; Long-term Durability; Intercellular Space Network; Microdistribution of Copper elements; Anti-termite attack; Anti-fungal attack; 安全性; 急性経口毒性試験; 目一次刺激性試験; 皮膚一次刺激性試験; 皮膚感作性試験; 復帰突然変異試験; CCC(キトサン銅複合体); 長期劣化耐久性

The purpose of this study is to confirm safety and long-term durability of a Chitosan-Copper Complex (CCC) treated woods based on the chemical safety tests and the field exposure testsThe safety of CCC was investigated at a private inspection sector of Safety and Evaluation of Foods and Agricultural Chemicals Center Ltd. for following five items, that is, poison test for eating (LD50), ocular irritation test, skin irritation test, skin allergy test and genetic-poison test. CCC showed strong positive reaction on ocular irritation test. CCC of LD50 test is much larger than 2000ppm. It was confirmed that CCC was very safety and able to recognized as an environmental friendly wood preservatives.Durability of the CCC treated woods, such as CCC impregnated wood-pegs and a CCC treated Sugi-log bench, was evaluated by the field tests. Wood pegs buried for 7 years near the termite colony showed no damages, and the log bench exposed for four years in outdoor also showed no signs of biodegradation.So far as the mechanism of anti-biodeterioration against termite and wood fungi attacks, the CCC microdistribution within the treated woods seemed to play an important role. The copper-elements of the CCC was selectively deposited within the free space of "intercellular spaces networks" which were formed between ray tissue and axial tracheids, within resin canal and between ray cells. This selective deposition of copper elements works very effectively against brown rot fugal attack and termite attack.These obtained results were presented at the fifth International Pacific Regional Wood Anatomist Conference (PRWAC) and the fourth International Wood Science Seminar (IWSS), both were held at Indonesia in 2002.

这项研究的目的是确认基于化学安全测试的壳聚糖 - 铜复合物（CCC）处理的木材的安全性和长期持久性，现场暴露测试了CCC的安全性，在私人检查领域的安全性和食品和农业化学品中心的评估和评估。基因毒验测试。 CCC在眼部刺激测试中显示出强烈的正反应。 LD50测试的CCC远大于2000ppm。据证实，CCC非常安全，能够被公认为是环保木质防腐剂。通过现场测试评估了经CCC处理过的木材（例如CCC处理的木材浸渍木材和经过CCC处理过的SUGI-LOG板）。在白蚁菌落附近埋葬了7年的木钉没有损害，室外四年暴露的原木长也没有显示出生物降解的迹象。只要针对白蚁和木材真菌攻击的抗二焦置术的机制，治疗木材中的CCC微分分布似乎起着重要作用。 CCC的铜元素被选择性地沉积在“射线组织和轴向气管之间，树脂管中以及射线细胞之间”之间形成的“细胞间空间网络”的自由空间中。这种铜元素的选择性沉积非常有效地针对棕色腐烂的攻击和白蚁攻击。这些结果在第五届国际太平洋地区木材解剖学会议（PRWAC）和第四届国际木材科学研讨会（IWSS）上呈现，两者均在2002年在印度尼西亚举行。