Research on X-ray measurements of Remodeling Stress in Living Bone Tissue

活骨组织重塑应力的X射线测量研究

• 批准号: 12480254
• 负责人: TADANO Shigeru
• 金额: $ 6.46万
• 依托单位: HOKKAIDO UVIERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12480254/
• 关键词: Biomechanics; Bone Structure; Remodeling; Cortical Bone; X-ray Diffraction; Residual Stress

Bone tissue is a composite material composed of hydroxyapatite (Hap) and collagen. Because Hap in bone tissue makes a crystal structure, an X-ray diffraction method is available to measure the strain of Hap. This study presents an X-ray diffraction method of measuring the residual stress/strain in bone tissue of rabbit's tibia . Bone powder of the diameter less than 40 micrometer was used as a control specimen at non-stressed state. From the measurements, it was clear that the distribution of residual stress existed in the bone tissue. The tensile residual stress at bone axial direction occurred in the proximal-medial region of rabbit's tibia. The compressive stress occurred in the other regions. In addition, the mechanism to generate the residual stress was investigated by sequential cutting of the tibia specimen from bone structure scale to bone tissue scale. The remodeling is a phenomenon that bone tissue and structure adapts functionally to mechanical environment. The residual stre … More ss will become a mechanical trigger to induce the remodeling.In the X-ray diffraction method using characteristic X-rays with a unique wavelength, Hap in compact bone has much lower crystallization than metal as steel. The peak position of diffracted intensity is not easy to determine form the gradual intensity-angle profile. This work proposes a method to calculate the lattice strain from the information of a whole diffraction profile without a peak position. In this experiment, strip specimens of 28x8x2 mm in size with their long axis aligned to the bone axial or the circumferential direction were cut from cortical bone in a shaft of bovine femur. To confirm the relationship between applied macroscopic strain and lattice strain in bone tissue, a four-point bending device was developed to apply bending load to the specimen during the X-ray irradiation. Macroscopic strain of the specimen was measured by a strain-gauge bonded to opposite side of the surface irradiated by X-rays. As a result, the accuracy of measurement by this method was better improved. Less

骨组织是一种由羟磷灰石（HAP）和胶原蛋白组成的复合材料。由于骨组织中的HAP是晶体结构的，因此可以使用X射线衍射方法来测量HAP的应变。这项研究提出了一种X射线衍射方法，用于测量兔胫骨骨组织中的残留应力/应变。直径小于40微米的骨粉被用作非压力状态下的对照样本。从测量值中可以明显看出，骨组织中存在残留应力的分布。骨轴向方向的拉伸残留应力发生在兔胫骨的近端媒体区域。压力应发生在其他地区。此外，通过连续切割胫骨标本从骨骼结构尺度到骨组织尺度进行的，研究了残余应力的机制。重塑是一种现象，即骨组织和结构在机械环境上适应了。残留的stre…更多的SS将成为一种机械触发，以诱导重塑。在使用具有独特波长的特征X射线的X射线衍射方法中，紧凑骨的HAP的结晶性比金属作为钢要低得多。衍射强度的峰位置并不容易确定成级强度角度谱。这项工作提出了一种从没有峰位置的整个衍射轮廓信息中计算晶格应变的方法。在此实验中，在骨轴向骨头的长轴或周向方向的长轴尺寸为28x8x2 mm的带状标本在牛股骨轴上从皮质骨上切开。为了确认骨骼组织中施加的宏观菌株和晶格菌株之间的关系，开发了一个四点弯曲装置，以在X射线照射期间对样品施加弯曲载荷。试样的宏观应变是通过X射线照射的表面对面的应变器键来测量的。结果，通过这种方法测量的准确性得到了更好的提高。较少的

项目成果

K.Fujisaki: "Lattice Strain Measurements of HAp Crystals in Bovine Cortical Bone"Proceedings of Joint Symposium on Mechanics of New Materials. 7-8 (2003)

K.Fujisaki：“牛皮质骨HAp晶体的晶格应变测量”新材料力学联合研讨会论文集。

J.Shibano: "Residual Stress in Hydroxyapatite by X-ray Diffraction Method"Proceedings of Joint Symposium on Mechanics of New Materials. 13-14 (2003)

J.Shibano：“X射线衍射法研究羟基磷灰石中的残余应力”新材料力学联合研讨会论文集。

S. Shibano, S. Tadano: "Residual Stress in HAP Coated Titanium Implant by X-ray Diffraction Method"Proceedings of International Congress on Biological and Medical Engineering. CD-ROM. (2002)

S. Shibano、S. Tadano：“通过 X 射线衍射法研究 HAP 涂层钛植入物中的残余应力”国际生物和医学工程大会论文集。

K.Fujisaki: "Lattice Strain of HAp Crystals in Bone Tissue Dsing X-ray Diffraction Method"Proceedings of International Congress on Biological and Medical Engineering, CD-ROM. (CD-ROM). (2002)

K.Fujisaki：“骨组织中 HAp 晶体的晶格应变 X 射线衍射法”国际生物和医学工程大会论文集，CD-ROM。

S.Tadano: "Residual Stress Measurements in Bone Tissue Dsing x-ray Diffraction"ASME International, Proceedings of ESDA 2002. (CD-ROM). (2002)

S.Tadano：“通过 X 射线衍射进行骨组织残余应力测量”ASME International，Proceedings of ESDA 2002。（CD-ROM）。