Evaluation of cortical activation area responsible for changes in orofacial function: An fMRI study

评估负责口面部功能变化的皮质激活区域：功能磁共振成像研究

基本信息

批准号：
12470458
负责人：
ONO Takashi
金额：
$ 9.28万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

Blood oxygenation level dependent (BOLD)-functional magnetic resonance imaging (fMRI) is known to be a noninvasive technique for studying human brain function. The purpose of this study, applying the above method to 8 normal right-handed volunteers, was to identify brain areas responsible for producing tongue movements and their relations with the individual chewing side preference. All subjects gave written informed consentand were studied with local ethical approval, and the chewing side preference was interviewed after the experiment. All subjects were trained, before the MR imaging, to perform tongue movements with visual feedback of electromyographic activities of orofacial muscles in order to minimize the artifacts onto the acquired images by motion of orofacial area. ASiemens Vision 1.5T MRI apparatus was used for image acquisition. The data were analyzed by SPM99. In the group analysis, marked increase of BOLD signals compared with the rest conditions was detected during tongue movements in primary sensorimotor cortices, supplementary motor area and cerebellum ; in all instances were these brain areas of both hemispheres activated upon all of protrusion, rignt and leftward tongue movements. By the individual-based analysis of BOLD signals during various tongue movements in 6 subjects with evident chewing side preference, the signal intensity of the primary sensorimotor cortex and the cerebellum tended to be greater in the contralateral and ipsilateral side of the chewing side preference, respectively. The results suggest that, in primary sensorimotor cortices responsible for tongue movements, there is a relationship between hemispheric dominance and chewing side preference across subjects.

血液氧合水平依赖性（BOLD）功能磁共振成像（fMRI）是研究人脑功能的无创技术。这项研究的目的将上述方法应用于8位正常右撇子志愿者，是确定负责产生舌头运动的大脑区域及其与单个咀嚼侧偏爱的关系。所有受试者均通过当地的道德认可对书面知情同意进行了研究，并在实验后采访了咀嚼方面的偏好。在MR成像之前，对所有受试者进行了训练，以通过视觉反馈对口面肌肉的肌肉运动反馈进行舌头运动，以最大程度地将伪像的伪像通过口面区域的运动最小化。 Asiemens Vision 1.5T MRI设备用于图像采集。数据通过SPM99分析。在小组分析中，与原发性感觉运动皮层，补充运动区和小脑的舌运动中检测到的剩余条件相比，大胆信号的明显增加。在所有情况下，所有突起，rignt和左舌运动都激活了两个半球的大脑区域。通过对6位受试者的各种舌头运动中的大胆信号进行基于个体的基于个体的分析，分别在咀嚼侧偏好的对侧和同侧方面，初级感觉运动皮层和小脑的信号强度分别更大。结果表明，在负责舌头运动的一级感官皮层中，半球优势与跨受试者咀嚼侧偏爱之间存在关系。