Evaluation of cortical activation area responsible for changes in orofacial function: An fMRI study

评估负责口面部功能变化的皮质激活区域：功能磁共振成像研究

基本信息

批准号：
12470458
负责人：
ONO Takashi
金额：
$ 9.28万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

Blood oxygenation level dependent (BOLD)-functional magnetic resonance imaging (fMRI) is known to be a noninvasive technique for studying human brain function. The purpose of this study, applying the above method to 8 normal right-handed volunteers, was to identify brain areas responsible for producing tongue movements and their relations with the individual chewing side preference. All subjects gave written informed consentand were studied with local ethical approval, and the chewing side preference was interviewed after the experiment. All subjects were trained, before the MR imaging, to perform tongue movements with visual feedback of electromyographic activities of orofacial muscles in order to minimize the artifacts onto the acquired images by motion of orofacial area. ASiemens Vision 1.5T MRI apparatus was used for image acquisition. The data were analyzed by SPM99. In the group analysis, marked increase of BOLD signals compared with the rest conditions was detected during tongue movements in primary sensorimotor cortices, supplementary motor area and cerebellum ; in all instances were these brain areas of both hemispheres activated upon all of protrusion, rignt and leftward tongue movements. By the individual-based analysis of BOLD signals during various tongue movements in 6 subjects with evident chewing side preference, the signal intensity of the primary sensorimotor cortex and the cerebellum tended to be greater in the contralateral and ipsilateral side of the chewing side preference, respectively. The results suggest that, in primary sensorimotor cortices responsible for tongue movements, there is a relationship between hemispheric dominance and chewing side preference across subjects.

血氧水平依赖（BOLD）功能磁共振成像（fMRI）被认为是研究人类大脑功能的无创技术。这项研究的目的是将上述方法应用于 8 名正常的右手志愿者，以确定负责产生舌头运动的大脑区域及其与个体咀嚼侧偏好的关系。所有受试者都签署了书面知情同意书，并在当地伦理批准的情况下进行了研究，并且在实验后对咀嚼侧偏好进行了采访。在 MR 成像之前，所有受试者都经过训练，通过口面部肌肉肌电活动的视觉反馈来执行舌头运动，以便最大限度地减少口面部区域运动对采集图像的伪影。使用西门子Vision 1.5T MRI设备进行图像采集。数据通过SPM99进行分析。在分组分析中，与休息条件相比，舌头运动时初级感觉运动皮层、辅助运动区和小脑检测到 BOLD 信号显着增加；在所有情况下，两个半球的这些大脑区域在所有伸出、向右和向左舌头运动时都会被激活。通过对 6 名具有明显咀嚼侧偏好的受试者各种舌头运动期间的 BOLD 信号进行个体化分析，初级感觉运动皮层和小脑的信号强度分别在咀嚼侧偏好的对侧和同侧趋于更大。结果表明，在负责舌头运动的初级感觉运动皮层中，受试者的半球优势和咀嚼侧偏好之间存在相关性。