Physiological and Pathophysiological roles of prostanoids revealed from studies using mice lacking their receptors

使用缺乏受体的小鼠进行的研究揭示了前列腺素的生理和病理生理作用

• 批准号: 11694269
• 负责人: USHIKUBI Fumitaka
• 金额: $ 4.22万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11694269/
• 关键词: prostanoids; prostaglandin; knockout mice; prostanoid receptor; fertilization; allergic asthma; platelets; ischemia-reperfusipn; トロンボキサン; 中枢神経機能; 肺高血圧症; 気管支喘息; 大腸癌; prostanoids; prostaglandin; knockout mice; prostanoid receptor; fertilization; allergic asthma; platelets; ischemia-reperfusipn; トロンボキサン; 中枢神経機能; 肺高血圧症; 気管支喘息; 大腸癌

The prostanoids are lipid mediators showing variable effects on many organs. Theirphysiological and pathophysiological roles in the body, however, have been largely unknown. We attmpted to clarify these roles using mice lacking the prostanoids receptors individually, and found several novel and important roles of prostanoids. They include a cardioprotective role of prostaglandin (PG)l_2 in ischemia-reperfusion injury, roles of PGE_2 via the EP_3 receptor in hemostasis, thromboembolism and alkari secretion in the duodenum, a role of PGD_2 as a mediator of allergic asthma, participation of PGE_2 via the EP_1 and EP_2 receptors in the carcinogenesis of colon, a regulatory role of PGE_2 via the EP_2 receptor of ovulation ad fertilization and a role of PGE_2 via the EP_4 receptor in bone resorption. Furthermore, other roles of prostanoids have been being clarified in many systems, such as central nervous, immune, cardiovascular and gastrointestinal systems. These results would contribute to the development of novel drugs able to control many pathological conditions, in which prostanoids have major roles.

前列腺素是脂质介质对许多器官的影响。然而，他们的身体生理和病理生理学在体内的作用在很大程度上是未知的。我们使用缺乏前列腺素受体的小鼠分别发现了这些作用，并发现了前列腺素的几种新颖而重要的作用。它们包括前列腺素（PG）L_2在缺血 - 重新灌注损伤中的心脏保护作用，PGE_2通过EP_3受体在止血中的受体，Thromboombolisp和Alkari分泌在DuododeNum中的分泌，DuododeNum在DuododeNum中的作用，PGD_2的作用，pgd_2作为Epge_ Epge_ 2 and epge_2 and epge_2 and epge_2 via ps and epge_2 via pergge_2 via ps and epge and epge and p.2通过结肠的致癌作用，是PGE_2通过EP_2受体AD受精的受体的调节作用，以及PGE_2通过EP_4受体在骨吸收中的作用。此外，在许多系统（例如中枢神经，免疫，心血管和胃肠道系统）中已经阐明了前列腺素的其他作用。这些结果将有助于开发能够控制许多病理状况的新型药物，前列腺素具有主要作用。