High-selective HPLC with chiral organogels

使用手性有机凝胶的高选择性 HPLC

• 批准号: 14350446
• 负责人: IHARA Hirotaka
• 金额: $ 8.7万
• 依托单位: Kumamoto University (2002, 2004)Kyushu University (2003)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14350446/
• 关键词: Organogels; Chirality; Enantiomer; Highly^ordered structures; Ordered structure; Liquid chromatography; Polymer grafting; Self-assembled systems; 誘起キラリティー; 円二色性スペクトル; 脂質膜; 高分子化有機ゲル; 誘起キラリティ; 円二色スペクトル; 脂質二分子膜; 光学活性; 円二色性; 分子配向膜; シアニン色素

Recently, organogel systems have been attractive. This is due to the facts that they can be produced through three-dimensional fibrous network formation with low-molecular compounds although conventional hydrogels are mostly produced by partial crosslinking of amorphous polymers. Therefore, organogel systems are often accompanied by supramolecualr functions such as enhancement of chirality. However, there are some distinct disadvantages compared with hydrogel systems. The most serious problem is due to the fact that organogels are mechanically fragile. Therefore, we have tried to polymerize organogels to extend their possible applications. In this study, we have focused on application of organogel systems for HPLC separation by stabilization of organogels. For this purpose, we designed (1)novel organogel-forming lipophilic compounds (lipids) and their physicochemical properties such as chirality and ordered structures were investigated. Also stabilization of organogels was carried out by (2)photo-induced polymerization of the polymerizable lipids prepared in this study and (3)radical polymerization ofa bulk solution with the non-polymerizable lipids. Also (4)HPLC separation has carried out with the chiral lipid-immobilized silica as packing materials and molecular-shape selectivity and chiral recognition ability were discussed with aromatic hydrocarbons as samples.

最近，有机凝胶系统很有吸引力。这是由于事实是，它们可以通过三维纤维网络形成产生，具有低分子化合物，尽管常规水凝胶主要是由无定形聚合物的部分交联产生的。因此，有机凝胶系统通常伴随着超元素的功能，例如增强手性。但是，与水凝胶系统相比，存在一些不同的缺点。最严重的问题是由于有机凝胶在机械上是脆弱的事实。因此，我们试图将有机凝胶聚合以扩展其可能的应用。在这项研究中，我们专注于有机凝胶系统通过稳定器官的HPLC分离的应用。为此，我们设计了（1）新型有机凝胶形成的亲脂化合物（脂质）及其物理化学特性，例如手性和有序结构。 （2）（2）本研究中制备的聚合脂质的光诱导的聚合聚合以及（3）与不可聚合脂质的散装溶液的基本聚合进行了稳定。 （4）HPLC分离已经用手性脂质涂成二氧化硅作为填料材料和分子形选择性和手性识别能力进行了，以芳族碳氢化合物作为样品进行了讨论。

项目成果

Selectivity enhancement for diastereomer separation in RPLC Using crystalline-organic phase-bonded silica instead of simply-hydrophobized silica

使用结晶有机相键合硅胶代替简单疏水化硅胶提高 RPLC 中非对映异构体分离的选择性

• 发表时间: 2002
• 期刊: Chromatographia Vol.56
• 作者: Y.Goto;K.Nakashima;K.Mitsuishi;M.Takafuji;S.Sakaki;H.Ihara
• 通讯作者: H.Ihara

Self-assembled organic phase for RP-HPLC.

用于 RP-HPLC 的自组装有机相。

• 期刊: Encyclopedia of Chromatography (in print)
• 作者: H.Ihara;M.Takafuji;T.Sakurai;T.Sagawa;S.Nagaoka
• 通讯作者: S.Nagaoka

Molecular-length and chiral discriminations by beta-structural poly(L-alanine) on silica.

• DOI: 10.1016/j.chroma.2004.08.062
• 发表时间: 2005-05
• 期刊: Journal of chromatography. A
• 作者: A. Shundo;T. Sakurai;M. Takafuji;S. Nagaoka;H. Ihara

H.Ihara, T.Sakurai, T.Yamada, T.Hashimoto, M.Takafuji, T.Sagawa, H.Hachisako: "Chirality Control of Self-Assembling Organogels from Lipophilic L-Glutamide Derivative with Metal Chlorides"Langmuir. 18. 7120-7123 (2002)

H.Ihara、T.Sakurai、T.Yamada、T.Hashimoto、M.Takafuji、T.Sakawa、H.Hachisako：“亲脂性 L-谷酰胺衍生物与金属氯化物的自组装有机凝胶的手性控制”Langmuir。

Formation of nanofibrillar aggregates by water-soluble beta-structural oligopeptide, (L-Lys-L-Leu)8

水溶性 β 结构寡肽 (L-Lys-L-Leu)8 形成纳米纤维聚集体

• 发表时间: 2003
• 期刊: Chemistry Letters
• 影响因子: 1.6
• 作者: T.Sakurai;M.Koga;M.Takafuji;H.Ihara
• 通讯作者: H.Ihara