High-selective HPLC with chiral organogels

使用手性有机凝胶的高选择性 HPLC

• 批准号: 14350446
• 负责人: IHARA Hirotaka
• 金额: $ 8.7万
• 依托单位: Kumamoto University (2002, 2004)Kyushu University (2003)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14350446/
• 关键词: Organogels; Chirality; Enantiomer; Highly^ordered structures; Ordered structure; Liquid chromatography; Polymer grafting; Self-assembled systems; 誘起キラリティー; 円二色性スペクトル; 脂質膜; 高分子化有機ゲル; 誘起キラリティ; 円二色スペクトル; 脂質二分子膜; 光学活性; 円二色性; 分子配向膜; シアニン色素

Recently, organogel systems have been attractive. This is due to the facts that they can be produced through three-dimensional fibrous network formation with low-molecular compounds although conventional hydrogels are mostly produced by partial crosslinking of amorphous polymers. Therefore, organogel systems are often accompanied by supramolecualr functions such as enhancement of chirality. However, there are some distinct disadvantages compared with hydrogel systems. The most serious problem is due to the fact that organogels are mechanically fragile. Therefore, we have tried to polymerize organogels to extend their possible applications. In this study, we have focused on application of organogel systems for HPLC separation by stabilization of organogels. For this purpose, we designed (1)novel organogel-forming lipophilic compounds (lipids) and their physicochemical properties such as chirality and ordered structures were investigated. Also stabilization of organogels was carried out by (2)photo-induced polymerization of the polymerizable lipids prepared in this study and (3)radical polymerization ofa bulk solution with the non-polymerizable lipids. Also (4)HPLC separation has carried out with the chiral lipid-immobilized silica as packing materials and molecular-shape selectivity and chiral recognition ability were discussed with aromatic hydrocarbons as samples.

最近，有机凝胶系统很有吸引力。这是因为它们可以通过低分子化合物形成三维纤维网络来生产，尽管传统的水凝胶大多是通过无定形聚合物的部分交联生产的。因此，有机凝胶系统通常伴随着超分子功能，例如增强手性。然而，与水凝胶系统相比，存在一些明显的缺点。最严重的问题是由于有机凝胶在机械上很脆弱。因此，我们尝试聚合有机凝胶以扩展其可能的应用。在本研究中，我们重点关注有机凝胶系统通过稳定有机凝胶进行 HPLC 分离的应用。为此，我们设计了（1）新型有机凝胶形成亲脂性化合物（脂质），并研究了它们的物理化学性质，例如手性和有序结构。还通过（2）本研究中制备的可聚合脂质的光诱导聚合和（3）本体溶液与不可聚合脂质的自由基聚合来稳定有机凝胶。 (4)以手性脂质固定二氧化硅为填料进行了HPLC分离，并以芳香烃为样品，探讨了分子构型选择性和手性识别能力。

项目成果

Selectivity enhancement for diastereomer separation in RPLC Using crystalline-organic phase-bonded silica instead of simply-hydrophobized silica

使用结晶有机相键合硅胶代替简单疏水化硅胶提高 RPLC 中非对映异构体分离的选择性

• 发表时间: 2002
• 期刊: Chromatographia Vol.56
• 作者: Y.Goto;K.Nakashima;K.Mitsuishi;M.Takafuji;S.Sakaki;H.Ihara
• 通讯作者: H.Ihara

Self-assembled organic phase for RP-HPLC.

用于 RP-HPLC 的自组装有机相。

• 期刊: Encyclopedia of Chromatography (in print)
• 作者: H.Ihara;M.Takafuji;T.Sakurai;T.Sagawa;S.Nagaoka
• 通讯作者: S.Nagaoka

Molecular-length and chiral discriminations by beta-structural poly(L-alanine) on silica.

• DOI: 10.1016/j.chroma.2004.08.062
• 发表时间: 2005-05
• 期刊: Journal of chromatography. A
• 作者: A. Shundo;T. Sakurai;M. Takafuji;S. Nagaoka;H. Ihara

H.Ihara, T.Sakurai, T.Yamada, T.Hashimoto, M.Takafuji, T.Sagawa, H.Hachisako: "Chirality Control of Self-Assembling Organogels from Lipophilic L-Glutamide Derivative with Metal Chlorides"Langmuir. 18. 7120-7123 (2002)

H.Ihara、T.Sakurai、T.Yamada、T.Hashimoto、M.Takafuji、T.Sakawa、H.Hachisako：“亲脂性 L-谷酰胺衍生物与金属氯化物的自组装有机凝胶的手性控制”Langmuir。

Formation of nanofibrillar aggregates by water-soluble beta-structural oligopeptide, (L-Lys-L-Leu)8

水溶性 β 结构寡肽 (L-Lys-L-Leu)8 形成纳米纤维聚集体

• 发表时间: 2003
• 期刊: Chemistry Letters
• 影响因子: 1.6
• 作者: T.Sakurai;M.Koga;M.Takafuji;H.Ihara
• 通讯作者: H.Ihara