Mathematical model for quantitatively analysis the pathophysiological characteristics of mouse photoreceptor cell

定量分析小鼠感光细胞病理生理特征的数学模型

• 批准号: 22K20514
• 负责人: Muangkram Yuttamol
• 金额: $ 1.33万
• 依托单位: Ritsumeikan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-08-31 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K20514/
• 关键词: ion channels; ion homeostasis; ionic current model; simulation model; mathematical model; photoreceptors; mouse retina; Ion channels; Ion homeostasis; Ionic current model; Mathematical model; Retinal diseases

We have constructed a novel mathematical model of the mouse photoreceptor to quantitatively describe the electrophysiological characteristics of ionic current dynamics and the changes in intracellular ion concentrations under a variety of light intensities. The new model can be used to explain the pathophysiological changes in electrophysiological properties due to mutations in the ionic current-encoding genes of photoreceptors. The results have been reported in the annual conferences, including JSMBE, LE, Kinki PS, and PSJ. Currently, we have developed a model to estimate the energy consumption&production of photoreceptors, which are linked to several retinal diseases. A better understanding of energy demand&supply may provide an effective tool for analyzing new therapeutic approaches.

我们构建了一种新颖的小鼠光感受器数学模型，以定量描述离子电流动力学的电生理特征以及各种光强度下细胞内离子浓度的变化。新模型可用于解释由于光感受器离子电流编码基因突变而导致的电生理特性的病理生理变化。其结果已在JSMBE、LE、Kinki PS、PSJ等年会上进行了报告。目前，我们已经开发了一个模型来估计光感受器的能量消耗和产生，这与多种视网膜疾病有关。更好地了解能量需求和供应可以为分析新的治疗方法提供有效的工具。

项目成果

Electrophysiological characteristics of light responses in mammalian photoreceptor: a mathematical model.

哺乳动物感光器光反应的电生理特征：数学模型。

• 发表时间: 2022
• 作者: Yuttamol Muangkram;Saya Ito;Yukiko Himeno;Akira Amano
• 通讯作者: Akira Amano

A mathematical model for explaining an impact of genetic mutations on ionic currents of photoreceptor

解释基因突变对感光器离子电流影响的数学模型

• 发表时间: 2023
• 作者: Yuttamol Muangkram;Saya Ito;Yukiko Himeno;Akira Amano
• 通讯作者: Akira Amano

Effect of Voltage-dependence and Reaction Rate of Ion Binding Process of Mathematical Model of Na/Ca Exchanger (NCX) Considering Thermodynamics Constraints

考虑热力学约束的 Na/Ca 交换器 (NCX) 数学模型的离子结合过程的电压依赖性和反应速率的影响

• 发表时间: 2023
• 作者: OU Shaocong;Keika Oyama;Masaaki Furukawa;Yuttamol Muangkram;Yukiko Himeno;Akira Amano
• 通讯作者: Akira Amano

Electrophysiological characteristics of photoreceptor response to light: a mathematical model.

光感受器对光反应的电生理特征：数学模型。

• 发表时间: 2022
• 作者: Yuttamol Muangkram;Junpei Takita;Yukiko Himeno;Akira Amano
• 通讯作者: Akira Amano

Pathophysiological changes in electrophysiological properties due to mutations in ionic current-encoding genes of photoreceptor: A mathematical model

光感受器离子电流编码基因突变导致的电生理特性的病理生理变化：数学模型

• 发表时间: 2022
• 作者: Yuttamol Muangkram;Saya Ito;Yukiko Himeno;Akira Amano
• 通讯作者: Akira Amano