Control of Environmental Responses on the Surface of Multiphase Polymers for Molecular Design of Biomaterials

用于生物材料分子设计的多相聚合物表面环境响应控制

基本信息

批准号：
06680850
负责人：
SHIOMI Tomoo
金额：
$ 1.34万
依托单位：
Nagaoka University of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

The surface study is very important for molecular design of polymeric biomaterials because the materials interact with organism on their surface but not in the bulk. In particular, the polymer surface may be changeable by responding to environment because of its low surface energy and flexible molecules. The purpose of this study is to clarify the mechanism of the formation and environmental responses of the surface for multiphase polymers and to establish synthesis methods of the functional polymers having environmental responsibility. The results obtained in this study are as follows :Various multiphase copolymers were synthesized in the techniques of telechelic polymers and macromonomers. In formation of the polymer surface in an air atmosphere the surface was covered by the low surface energy component, but in immersion in water the surface composition was rearranged rapidly to be covered almost completely by another component, and such compositional rearrangement was reversible. This ability was greater for graft copolymers than for block copolymers. For the three-component graft copolymers having a block copolymer as a graft three-layr structure was observed in the vicinity of the surface. This suggests that the graft component chains have a unique conformation near the surface owing to the surface energy difference between their components. Furthermore, environmental responses were studied for the copolymers having glassy and crystalline component chains. The glassy component showed environmental responsibility on the surface. This may mean that the glass transition temperature on the surface is lower than that in the bulk. On the other hand, the crystalline components were rigid for responsibility.

表面研究对于聚合物生物材料的分子设计非常重要，因为材料在其表面而不是在本体上与生物体相互作用。特别是，由于其低表面能和柔性分子，聚合物表面可以通过响应环境而改变。本研究的目的是阐明多相聚合物表面的形成和环境响应机制，并建立具有环境责任的功能聚合物的合成方法。本研究得到的结果如下：采用遥爪聚合物和大分子单体技术合成了多种多相共聚物。在空气气氛中形成聚合物表面时，表面被低表面能组分覆盖，但在水中浸没时，表面组成迅速重新排列，几乎完全被另一种组分覆盖，并且这种组成重新排列是可逆的。接枝共聚物的这种能力比嵌段共聚物更强。对于具有作为接枝三层结构的嵌段共聚物的三组分接枝共聚物，在表面附近观察到。这表明接枝组分链由于其组分之间的表面能差异而在表面附近具有独特的构象。此外，还研究了具有玻璃状和结晶组分链的共聚物的环境响应。玻璃状部件在表面上表现出对环境的责任。这可能意味着表面的玻璃化转变温度低于本体的玻璃化转变温度。另一方面，晶体成分对于责任是严格的。