Study on Lifestyle Related to Deterioration in Cognitive Function for Early Detection of Dementia in Elderly Persons.

与认知功能恶化相关的生活方式研究，以早期发现老年人痴呆症。

基本信息

批准号：
06670428
负责人：
FUJIWARA Nakako
金额：
$ 1.34万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

An epidemiological study was conducted in healthy elderly volunteers aged 60 and over to investigate :1.relationships between age and lifestyle, cognitive functions and physical strength.2.simple screening for dementia in early stages.Subjects, who gave informed consent to the study, included 71 males and 231 females ; average ages : 73.0(]SY.+-。[)6.5 for males, 70.1(]SY.+-。[)6.0 for females. Items surveyed : 52 questions on lifestyle, 5 physical conditions, 5 physical strength items, PGC morale, Zung' s depression scale, and 5 cognitive tests consisting of MMS (mini-mental state), PAL (paired associate learning), Kana (Japanese syllabary)-selections, Raven' s, and Rey complex figure. MMS mean scores were 26.1(]SY.+-。[)3.5 for males and 26.9(]SY.+-。[)2.5 for females, which means subjects did not suffer from dementia clinically. Among the subjects, 111 were also screened by brain MRI (magnetic resonance imaging). The following tendencies were shown with age : for males, light sleep, les … More s alcohol drinking, cheerfulness ; for females, longer sleep, timidity, depression, low body mass index, low diastolic pressure ; for both sexes, difficulty chewing difficulty reading newspaper, decrease in grip and quadriceps muscle strength, slow movement, loss of balance, and deterioration in 5 cognitive tests. Infarction including slight findings was found in 71.4% of males and 66.7% of females 65-69 years, and was over 90% in both sexes 70 years and over. Atrophy including slight findings occurred in 28.6% of males and 26.7% of females at 65-69 years and in 45.5% of males and 26.3% of females at 75-79 years old. Characteristics of subjects with some or slight cerebral infarction or atrophy from MRI examination were : males : deterioration in cognitive functions for MMS,PAL,Rey's (copy) tests, and slow movement ; females : low Kanaselection score, loss of balance ; both sexes : longer sleep and low Raven' s test scores. Some indices obtained could be used for early detection of deterioration in neuropsychological functions. Less

在60岁及以上的健康老年志愿者中进行了一项流行病学研究，调查：1.年龄与生活方式、认知功能和体力之间的关系。2.早期痴呆症的简单筛查。知情同意研究的受试者，其中男性 71 名，女性 231 名；平均年龄：男性 73.0(]SY.+-.[)6.5，女性 70.1(]SY.+-.[)6.0。调查项目：52个生活方式问题、5个身体状况、5个体力项目、PGC士气、Zung抑郁量表、以及由MMS（迷你精神状态）、PAL（配对联想学习）、假名（五十音图）组成的5个认知测试-男性和女性的选择、Raven 和 Rey 综合体平均得分为 26.1(]SY.+-.[)3.5。女性为26.9(]SY.+-.[)2.5，这意味着受试者临床上没有患有痴呆症，其中111名受试者也接受了脑部MRI（磁共振成像）筛查，随年龄的变化显示出以下趋势：男性，睡眠浅，饮酒少，性格开朗；女性，睡眠时间长，胆怯，抑郁，体重指数低，舒张压低；男性，咀嚼困难，阅读报纸困难， 65-69 岁的男性和女性中，握力和股四头肌力量下降、运动缓慢、失去平衡和恶化，其中 71.4% 的男性和 66.7% 的女性均超过 90%。 70 岁及以上人群中，65-69 岁以及 28.6% 的男性和 26.7% 的女性出现萎缩（包括轻微症状）。 75-79 岁的 45.5% 的男性和 26.3% 的女性通过 MRI 检查出现一些或轻微的脑梗塞或萎缩，其特征为：男性：MMS、PAL、Rey's（复制）测试的认知功能恶化。运动缓慢；女性：Kanaselection 分数低，失去平衡；男女：睡眠时间较长，Raven 测试分数低。神经心理功能恶化较少。