Design of Stimulus-responsive Functional Molecule

刺激响应功能分子的设计

基本信息

批准号：
06650983
负责人：
NAKATSUJI Yohji
金额：
$ 1.28万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06650983/
关键词：
synthetic ionophore membrane transport molecular recognition alkali metal ion alkaline earth metal ion

项目摘要

In this study, we prepared a variety of new macrocyclic and open-chain compounds with good complexation properties toward alkali metal and alkaline earth metal cations. One of the remarkable characteristics of these compounds is that they respond to a kind of stimulus such as pH.The results are summarized as followes.1.Five synthetic ionophores containing two carboxylic acid groups were synthesized as the carriers for alkaline earth metal cations. Among them, the lipophilic derivative having a trimethylene bridge and plural quinaldate moieties selectively transported barium ion from the basic aqueous phase to the acidic aqueous through the bulk dichloromethane liquid membrane.2.Two types of noncyclic proton-ionizable ionophores such as lipophilic quinaldic acid and nitrophenol derivatives selectively transported lithium ion from the basic source phase to the acidic receiving phase through the emulsion liquid membrane (ELM) and the results were compared with those obtained in the bulk l … More iquid membrane (BLM) system. The transport velocity was extremely increased in comparison with that of the latter system, though the lithium ion selectivity was moderate.3.A series of C-pivot tripodal ligands containing a 2-methylglycelol unit were prepared and their complexation properties towards alkali metal cations were examined by the solvent extraction method and UV spectroscopy. These types of compounds possessed a higher extractability than the other type of tripodal ligand derived from trimethylolethane. This finding clearly shows that the proper selection of the basic skeleton structure is important for the molecular design of C-pivot tripodal ligands.4.New types of monoazacryptands were prepared and their complexation properties toward alkali metal cations were examined by the solvent extraction method, UV spectroscopy, X-ray crystal analysis, and liquid membrane transport. A lipophilic macrobicyclic polyether consisting of two 18-crown-6-rings and one 20-crown-6-ring was found to be a highly selective potassium ion carrier through a bulk liquid membrane by pH control. Less

在这项研究中，我们制备了多种新的大环和开链化合物，这些化合物对碱金属和碱土金属阳离子具有良好的络合性能，这些化合物的显着特征之一是它们对pH等刺激有反应。主要研究结果如下： 1.合成了五种含有两个羧酸基团的合成离子载体作为碱土金属阳离子的载体，其中具有三亚甲基桥和多个亲脂性衍生物。喹哪酸盐部分通过本体二氯甲烷液膜选择性地将钡离子从碱性水相转移到酸性水相。2.两类非环状质子电离离子载体，例如亲脂性喹哪二酸和硝基苯酚衍生物，选择性地将锂离子从碱性源相转移到酸性水相。通过乳化液膜 (ELM) 的酸性接收相，并将结果与散装液中获得的结果进行比较……更多尽管锂离子选择性适中，但与后一种体系相比，传输速度大大提高。 3.制备了一系列含有2-甲基甘油单元的C轴三足配体并对其进行了研究。通过溶剂萃取法和紫外光谱检查了这些类型的化合物比其他类型的三羟甲基乙烷衍生的三足配体具有更高的可萃取性。这一发现清楚地表明，正确选择基本骨架结构对于C枢轴三足配体的分子设计非常重要。4.制备了新型单氮杂穴状配体，并通过溶剂萃取法考察了其对碱金属阳离子的络合性能。紫外光谱、X射线晶体分析和液膜传输发现了一种由两个18冠6环和一个20冠6环组成的亲脂性大双环聚醚。通过 pH 控制，成为通过本体液膜的高选择性钾离子载体。