The study of interstitial thermochemotherapy using Implant Heating System for oral cancer

种植体加热系统间质热化疗治疗口腔癌的研究

基本信息

批准号：
05807191
负责人：
TOHNAI Iwai
金额：
$ 1.28万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

Thermotolerance and local immune response in oral mucoas were observed for basic research of thermochem otherapy using Implant Heating System(IHS). Hsp40 was induced not only by heating but also sodium arsenite and prostaglandin in the same as hsp70. The extent of thermotolerance correlated well with the relative amount of hsp70 and 40. These results suggested that hsp40 is good predictor of thermotolerance in addition to hsp70. To examine effects of heat on immunologically responsive cells in oral mucosa, mouse tongue were heated by IHS.The densities of Langerhans cells and Thy-1-positive cells rapidly increased within 3 h after the treatment. Electron microscopy confirmed that Langerhans cells in the tongue epithelium formed clusters with lymphcytic cells, suggesting an active response to the hyperthermia. In clinical trial, 19 patients with oral cancer were treated by thermochemotherapy using IHS.Thirteen patients of 19 underwent thermochemotherapy before operation. As a results, CR was observed in 11 patients and PR in 2 patients, and postoperative pathological examination showed no residual tumor cells in 12 patients. Other 6 patients were only umderwent thermochemotherapy without operation. As a results, CR was observed in all 6 patients. It was suggested that thermochemotherapy using IHS is promising as a new therapy for oral cancer, because it dose not necessitate surgery or radiotherapy and hence improves the QOL of patient with oral cancer.

观察到使用植入物加热系统（IHS）观察到口服粘膜中的热耐耐药性和局部免疫反应。 HSP40不仅是通过加热，还通过与HSP70相同的砷和前列腺素诱导的。耐热性的程度与HSP70和40的相对量很好地相关。这些结果表明，除HSP70外，HSP40是良好的耐热性预测指标。为了检查热量对口服粘膜免疫反应性细胞的影响，通过IH加热小鼠舌头。在治疗后3小时内，兰格汉细胞的密度和THY-1阳性细胞的密度迅速增加。电子显微镜证实，舌上上皮的兰格汉细胞用淋巴细胞形成簇，表明对高温的活性反应。在临床试验中，使用IH的19例口腔癌患者进行了19例口腔癌。结果，在11例患者中观察到CR，2例患者观察到CR，术后病理检查显示12例患者没有残留的肿瘤细胞。另外6例患者只有未手术的umderwent热化学疗法。结果，在所有6例患者中都观察到CR。据建议，使用IHS的热化学疗法是一种针对口腔癌的新疗法，因为它不需要手术或放疗，因此可以改善口腔癌患者的质量。