Development of the concentration and separation system for multi-compornents by ion-pair phase separation phenomena with fluorosurfactant

利用含氟表面活性剂离子对相分离现象开发多组分浓缩分离系统

基本信息

批准号：
05805068
负责人：
IGARASHI Shukuro
金额：
$ 1.34万
依托单位：
Ibaraki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

New two types of three-phase separation phenomena were found by the charge neutralization of perfluorooctanate ion ; they are amine type in the neutral pH to alkaline solution and that of polar organic solvent in the acidic solution.In this study, the concentration and separation of several kinds of metal-chelate and physiological active substrates have been discussed in detail based on fundamental findings obtained from these phase separation phenomena.In the amine type (e.g.the case in the presence of n-amylamine), threephase separation phenomenon was confirmed in the pH range of 7 to 8.Each phases were successively water phase and two kinds of water-immisible phase (second phase and first phase) from upper side.The homogeneous liquid-liquid extraction method using these phenomena was applied to three components such as L-ascorbic acid, hemogrobin and alpha, beta, gamma, delta-tetrakis (4-trimethylaminophenyl) porphine (TTMAPP) assuming that separate the medical substances in human b … More lood.As the results, they were able to be separated into water (L-ascorbic acid), second (hemoglobin) and first (TTMAPP) phases, respectively using only a one-step process with addition of amylamine to the perfluorooctanoic acid solution.On the other hand, in the polar organic solvent type (e.g.the case in the presence of dimethylsulfoxide), the three-phase separation phenomenon was confirmed in the pH range of 0.42 to 0.46.This extraction method was applied to eight kinds of synthetic water-soluble porphyrin.As the results, three kinds of water-soluble porphyrin was quantitatively extracted and separated in water phase, second phase and first phase, respectively.The structure and physico-chemical property of these solutes is an important as a model when this extraction method is applied to the separation for other solutes.In conclusion, above-described valuable results for the development of new separation method "multi-compornents homogeneous liquid-liquid extraction"was obtained during the past two years.In the near future, the discovery of novel multi-phase separation phenomenon and the application to the extensive sample containing useful solute would be aggressively done. Less

新型的两种类型的THENOMENA是对碱性溶液的全氟离子和酸性溶液中的Orar或Ganic溶剂的中和根据从这些hase分离现象获得的基本发现。在胺类型中（例如，在存在N-淀粉胺的情况下），在7至8的pH范围内确认了三个相距现象。每个相都是类型的Suter阶段使用THENOMENA的水易生相（第二相和第一相）的液态液液体提取方法，将其应用于托雷斯成分，例如L-欧舒巴酸，霍尔莫尔蛋白和α，β-苯甲酸酯，Delta-tetrakis（4-三甲基氨基苯基）卟啉（TTMAPP）（TTMAPP）（TTMAPP） Assuming That Separate THE MEDICAL Substance in Human B… More Lood.as The Results, They Were Able to Be Separated Into Water ( L-ascorbic Acid), Second (Hemoglobin) and First (TTMAPP) Phases, Respection Using ONE-STEP PROCESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS Set另一方面，在极性有机溶剂中（例如，在二甲基硫氧化物的存在下），在pH值为0.42至0.46中确认了三相分离。卟啉的结果是定量提取并在水相中分离的，这些溶质的第二阶段和第一阶段是模型窃窃私语提取方法方法方法的其他溶质分离方法。在过去的两年中，新的分离方法的开发“多鸡蛋液液体提取” IND。在不久的将来，发现新型的多阶段分离现象以及对广泛包含有用的溶质的应用将积极地完成。较少的