EXPERIMENTAL STUDY ON THE PATHOPHISIOLOGY OF THE TEMPOROMANDIBULAR JOINT RELATED WITH THE PATHOGENESIS OF TEMPOROMANDIBULAR DISORDERS

颞下颌关节病理学与颞下颌关节紊乱病发病相关的实验研究

• 批准号: 04671248
• 负责人: KAKUDO Kenji
• 金额: $ 1.34万
• 依托单位: OSAKA DENTAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04671248/
• 关键词: Temporomandibular joint; Pathophisiology; Stress analysis; Finite element method; Bone strain; Intraarticular pressure; Ultrastructure; 滑膜; 咬合異常; 電顕; 下顎運動; 顎関節症; 力学解析; ストレインゲージ

In this study, the following four aspects on the pathophisiology of the temporomandibular joint related with the pathogenesis of temporomandibular disorders were researched. A study was made of the mechanical behavior of the temporomandibular joint under occlusal force in normal occlusion or malocclusion using finite element method. When the abnormal mechanical loading was produced in the temporomandibular joint, it was suggested that the bony changes such as addition or absorption occurred. Strain measurements were taken on the cerebral surface of the squamous part of human temporal bone (mandibular fossa) during mandibular movements. It was suggested that during mandibular movements a buffer effect on the forces is produced not only by the articular disc but also by the bone of the upper wall of the mandibular fossa. Intraarticular pressure within the superior aspect of the temporomandibular joint was examined during mandibular movements. It was revealed that the temporomandibular joint had the pumping function. Thus, this function plays an important role in the nutritional exchange between the vascular system and the articular cartilage. The effect of loss of bilateral molars on the temporomandibular joint synovium was examined by electron microscopy. At 24 months, the intercellular space of the synovium was tightly filled with mature collagen in the temporomandibular joint.

本研究从以下四个方面对与颞下颌疾病发病机制相关的颞下颌关节病理学进行了研究。采用有限元方法研究了正常咬合和错牙合时颞下颌关节在咬合力作用下的力学行为。当颞下颌关节产生异常机械负荷时，提示发生了添加或吸收等骨性变化。在下颌运动过程中，对人颞骨鳞状部分（下颌窝）的大脑表面进行应变测量。有人认为，在下颌运动过程中，对力的缓冲作用不仅由关节盘产生，而且还由下颌窝上壁的骨骼产生。在下颌运动期间检查颞下颌关节上部的关节内压力。结果表明，颞下颌关节具有泵血功能。因此，这种功能在血管系统和关节软骨之间的营养交换中起着重要作用。通过电子显微镜检查双侧磨牙缺失对颞下颌关节滑膜的影响。 24个月时，颞下颌关节滑膜的细胞间隙被成熟的胶原蛋白紧密填充。

项目成果

大竹,智子: "臼歯欠損が顎関節滑膜に及ぼす影響に関する電顕的研究" 日本口腔外科学会雑誌. 39(発表済み、雑誌未着). (1993)

Otake, Tomoko：“磨牙缺失对颞下颌关节滑膜影响的电子显微镜研究”，日本口腔颌面外科杂志 39（已发表，尚未在该杂志上接收）。

覚道 健治: "食品咬合時のサル顎関節下顎窩の力学的反応" 日本顎関節学会雑誌. 5. (1993)

Kenji Kakudo：“食物咬合期间猴子颞下颌关节下颌窝的机械反应”日本颞下颌关节学会杂志 5。（1993）。

覚道,健治: "下顎運動および下顎位の変化に伴う顎関節腔内圧の変動" 日本口腔科学会雑誌. 43(発表予定). (1994)

Kakudo，Kenji：“与下颌运动和下颌位置变化相关的颞下颌关节腔压力的变化”，日本口腔医学会杂志 43（待出版）。

Satoko OTAKE: "Electron microscopic study of the effect of loss of molars on the synovium of the temporomandibular joint." Jpn J Oral Maxillofac Surg. 39 : (in press). (1993)

Satoko OTAKE：“通过电子显微镜研究臼齿缺失对颞下颌关节滑膜的影响。”

Kenji KAKUDO: "Intra-articular responses in the human temporomandibular joint during mandibular movements and altered mandibular positions." J Jpn Stomatol Soc. 43 : (in press). (1994)

Kenji KAKUDO：“下颌运动和改变下颌位置时人类颞下颌关节的关节内反应。”