Flow characteristics and response to vasoactive drugs in intermal thoracic artery and gastroepiploic artery

胸内动脉和胃网膜动脉的血流特征及对血管活性药物的反应

• 批准号: 04670820
• 负责人: NAKAZAWA Satoshi
• 金额: $ 1.34万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670820/
• 关键词: Gastroepiploic artery; Internal thoracic artery; Response to vasoactive drugs; Free flow; Destribution of blood flow; Administration of gastrin; Administration of norepinephrine; in situ状態; ドパミン負荷; 冠状動脈バイパス術; 動脈グラフト; 薬剤負荷

We studied flow characteristics and response to vasoactive drugs in gastroepiploic artery(GEA) and internal thoracic artety(ITA). The GEA flow was obtained by free folw ; that is, a drip for a minute opening the end of pedicle GEA.Furthermore, aortic flow and celiac arterial flow were measured by magnetic flow probe. The administration of vasoactive drugs (chlorpromazine, vagostigumine, and gastrin) induced a increase in both celiac arterial flow and GEA flow. Adding norepinephrine stepwisely, the GEA flow increased remarkably, in spite of celiac arterial flow. The ITA flow was obtained by both free flow and the flow of intact ITA, In the intact ITA, the ITA flow was decreased by the administration of dopamine, norepinephrine. On the other hand, it did not remarkably change in free flow. In the experiment with cardiopulmonary bypass, the GEA and ITA flow were not enougn measured, because of the individual diffrence in graft length, and the difficulty in between surgical technique and management of cardiopulmonary bypass. In future, it is neccessary to study the flow cahracteristics and response to vasoactive drugs in relation between coronary artery and graft vessels.

我们研究了胃皮动脉（GEA）和内部胸腔arteTy（ITA）中对血管活性药物的流动特征和反应。 GEA流由Free Folw获得；也就是说，通过磁流探针测量了椎弓根，主动脉流和腹腔动脉流的滴头。给药血管活性药（氯丙嗪，载量和胃癌）诱导腹腔动脉流量和GEA流量增加。尽管有腹腔动脉流动，但添加了去甲肾上腺素，GEA流量显着增加。 ITA流是通过自由流和完整的ITA流动获得的，在完整的ITA中，通过多巴胺（能型肾上腺素）的给药降低了ITA流动。另一方面，它没有明显改变自由流动。在使用心肺旁路的实验中，由于移植长度的个体差异，GEA和ITA流量未得到测量，并且在手术技术和心肺旁路的管理之间的难度。将来，研究冠状动脉和移植血管之间有关血管活性药物的流量和对血管活性药物的反应是必不可少的。

项目成果

Hisanaga MORO, M.D.et al.: "Flow characteristics and responses to vasoactive drugs in carise gastroepiploic artery" J Jpn Assn Thorac Surg.141. 433-437 (1993)

Hisanaga MORO，医学博士等人：“胃网膜动脉中的血流特征和对血管活性药物的反应”J Jpn Assn Thorac Surg.141。

諸 久永;他: "胃大網動脈グラフトの流量特性ならびに薬剤反応性に関する研究" 日本胸部外科学会雑誌. 41. 433-437 (1993)

Hisanaga Moro 等：“胃网膜动脉移植物的血流特性和药物反应性研究”日本胸外科学会杂志 41. 433-437 (1993)。