CARDIOSCOPIC IMAGING OF THE ATRIO-VENTRICULAR ANNULAR MOTIONS IN DOGS

狗房室环形运动的心镜成像

• 批准号: 05454388
• 负责人: NATSUAKI Masafumi
• 金额: $ 3.33万
• 依托单位: SAGAMEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454388/
• 关键词: Annuloplasty; Fiberoptic cardioscopy; De Vega'smethod; Tricuspid valve; Mitral valve; Annular motion; 心臓内視鏡; 僧帽弁形成術; 僧帽弁輪収縮; 弁輪運動; 三尖弁; 僧帽弁; De Vega法; flexible ving; rigid ving

In the present study, we have investigated the technology of direct imaging by fiberoptic cardioscopy to find out how the tricuspid annulus behavesin canine model of chronic tricuspid regurgitation with and without De Vega'sannuloplasty. The heart was perfused with transparent modified Tyrode's solution by working heart method, and annuli were observed and recorded on a high-speed video system in real time. Tricuspid valve annular area was calculated at 14 points during the cardiac cycle. The control group was studied in the normal condition, and the tricuspid regurgitation group was studied during four interventions : nontricuspid annuloplasty group and three tricuspid annuloplasty groups with reducing tricuspid valve annular area to 80%, 65% and 50% of that of the nontricuspid annuloplasty group by De Vega'srocedure. The amplitudes in tricuspid valve annular area narrowing were unchangedin the tricuspid annuloplasty group even when tricuspid annular area was reduced to 50% by De Vega's annuloplasty. Preserving the annular motion by De Vega'smethodor flexible ring methodmay have a great advantage to prevent regurgitation more effectively in various hemodynamic conditions in the clinical settings. These findings suggest that De Vega'sannuloplasty of flexible ring methodare reasonable methods that doespreserve the physiological annular motions.

在本研究中，我们研究了纤维心镜直接成像技术，以了解在有或没有 De Vega 瓣膜成形术的慢性三尖瓣反流犬模型中三尖瓣环的表现。采用工作心脏法对心脏进行透明改良Tyrode溶液灌注，并在高速视频系统上实时观察和记录心环。在心动周期期间的 14 个点计算三尖瓣环形面积。对照组在正常状态下进行研究，三尖瓣反流组在四次干预中进行研究：非三尖瓣环成形术组和三尖瓣环成形术组，将三尖瓣环面积缩小至非三尖瓣环成形术的80％、65％和50％根据德维加的程序进行分组。即使通过 De Vega 瓣环成形术将三尖瓣环面积缩小到 50%，三尖瓣环成形术组中三尖瓣环面积缩小的幅度也没有变化。在临床环境中的各种血流动力学条件下，采用 De Vega 方法或柔性环法保留环形运动可能具有更大的优势，可以更有效地防止反流。这些发现表明，De Vega 的柔性环瓣膜成形术是保留生理环运动的合理方法。

项目成果

Natsuaki M., Itoh T., Tomita S., Furukawa K.: "Importance of preserving the mitral subvalvular apparatus in mitral valve replacement" Ann Thorac Surg. 61 :. 585-590 (1996)

Natsuaki M.、Itoh T.、Tomita S.、Furukawa K.：“在二尖瓣置换术中保留二尖瓣下装置的重要性”Ann Thorac Surg。

Natsuaki M., Itoh T., Furukawa K.: "Evaluation of left ventricular wall motion after mitral valve replacement with preservation of both anterior and posterior or only posterior chordae tendineae." Jpn J Cardiovasc Surg. 24 :. 320-325 (1995)

Natsuaki M.、Itoh T.、Furukawa K.：“二尖瓣置换术后左心室壁运动的评估，同时保留前后腱索或仅保留后腱索。”

Naoki Minato: "Direct imaging of the tricuspid valve annular motions by fiberoptic cardioscopy in dogs" The Journal of Thoracic and Cardiovasculan Surgery. 104. 1545-1553 (1992)

Naoki Minato：“通过纤维光学心脏镜对狗的三尖瓣环形运动进行直接成像”《胸腔和心血管外科杂志》。

Naoki Minato: "Direct imaging of the tricuspid valve annular motions by fiberoptic cardioscopy in dogs with tricuspid regurgitation" The Jounal of Thoracic and Cardiovasculan Surgery. 104. 1554-1560 (1992)

Naoki Minato：“通过纤维光学心脏镜对患有三尖瓣反流的狗进行三尖瓣环形运动的直接成像”胸外科和心血管外科杂志。

Minato N., Itoh T.: "Direct imaging of the tricuspid valve annular motions by fiberoptic cardioscopy in dogs." J Thorac Cardiovasc Surg. 104 :. 1545-1553 (1992)

Minato N.，Itoh T.：“通过光纤心镜检查对狗的三尖瓣环形运动进行直接成像。”