Morphological and Physiological Studies for Age-Related Change in Gerbil's Cochlear Nucleus

沙鼠耳蜗核随年龄变化的形态学和生理学研究

• 批准号: 03454410
• 负责人: EDAMATSU Hideo
• 金额: $ 2.5万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454410/
• 关键词: GERBIL; AGING; AUDITORY FUNCTION; ABR; COCHLEAR NUCLEUS; NEURAL DEGENERATION; Vacuolation; Presbycusis; Auditory brainstem response; Cochlear microphonics; vacuole

A degenerative lesion of the auditory system of mongolian gerbil (Meriones unguiculatus) was reported by K.Morest et al., 1986. The lesion was evaculation confined to the cochlear nucleus (CN) and increased with age. This study was performed to explore an effect of age-related lesion in gerbil's CN on the auditory function. 30 gerbils from 21 days to 2 years and 3 months old were used. They have had no ear infection. The auditory function was electrophysiologically evaluated by recording of cochlear microphonics (CM) and auditory brain stem response (ABR). Then CN and cochlea were microscopically observed. Correlation of the occurrence of lesion was examined with change of CM and ABr.Evaculation in gerbil's CN began to appear at around 7 weeks of age and the lesion increased in number and size with age. Number of vacuoles in average was less than 5 for 7-week-old gerbils and more than 15 for over 4-month-old gerbils. Mean size of each vacuole was smaller than 50 mum^2 for the former ge … More rbils and became larger than 150 mum^2 for the latter. Unlikely with the age-related changes in the cochlear nucleus, no vacuole was seen in cochlea. CM thresholds of gerbils at the frequency range of 1 k - 8kHz increased with aging. The CM thresholds of 4-month-old gerbil were 20-30 dB lower than those of the over 2-year-old gerbils. Similarly with the change of CM thresholds, ABR thresholds increased 15-20 dB with their age. Latencies of ABR waves became elongated along with the increased thresholds. Inter-wave latencies between I and V were also more prolonged in over 2-year-old gerbils than in the younger gerbils. However this delay was almost same with the prolongation of latencies which was caused by the increased thresholds of ABR.The results of CM and ABR in this study showed that auditory function in the cochlea and brain stem pathway of gerbils reached adult levels at about 4 months of age and gradually decreased with age. So far we have not found the direct effect of lesions in the CN on the age-related auditory function of gerbils. Less

K. Morest等人，1986年报道了蒙古语Gerbil（Meriones unguilatus）的听觉系统的退化性病变。病变被疏散于人工耳蜗核（CN）并随着年龄的增长而增加。进行这项研究是为了探索Gerbil CN中与年龄有关的病变对听觉功能的影响。使用了30天的21天到2岁零3个月大的沙鼠。他们没有早期感染。通过记录人工耳蜗（CM）和听觉脑干反应（ABR）来评估听觉功能。然后观察到CN和耳蜗。检查了病变的发生的相关性随着CM的变化和ABR的变化检查，Gerbil的CN中的ABR蒸发开始出现在7周大左右，病变的数量和大小随着年龄的增长而增加。对于超过4个月大的沙鼠来说，7周龄的沙鼠的平均吸尘器数量小于5，超过15。对于以前的GE，每个真空的平均尺寸小于50 mum^2…更多的rbils，后来变成了150 mum^2。与人工耳蜗核的年龄相关变化不太可能，在耳蜗中未见真空。在1 K -8KHz的频率范围内，沙鼠的CM阈值随老化而增加。 4个月大的沙尔比尔的CM阈值比超过2岁的沙鼠低20-30 dB。与CM阈值的变化类似，ABR阈值随着年龄的增长增加了15-20 dB。随着阈值的增加，ABR波浪的延迟变得细长。与年轻的沙鼠相比，在超过2岁的沙鼠中，I和V之间的波间潜伏期的延长也要延长。但是，这种延迟的延迟几乎是相同的，这是由于ABR的阈值增加引起的。在这项研究中，CM和ABR的结果表明，在4个月大约4个月大的年龄较大的成年水平，耳蜗和脑干途径的听觉功能逐渐降低。到目前为止，我们还没有发现CN中病变对Gerbils年龄相关的听觉功能的直接影响。较少的

项目成果

枝松,秀雄: "聴覚中枢路の経時的変性の種特異性の形態学的検討" 日本耳鼻咽喉科学会会報. 96(10). 1647 (1993)

Edamatsu, Hideo：“中枢听觉通路时间变性的形态学研究”日本耳鼻喉科协会通报 96(10)。

H.Edamatsu: "Gerbil's Age-related Auditory Function & Degeneration of Cochlear Nucleus." XXI International Congress of Audiology.45. 44- (1992)

H.Edamatsu：“沙鼠的与年龄相关的听觉功能

枝松秀雄: "聴覚中枢路の経時的変性の種特異性の形態学的検討" 日本耳鼻咽喉科学会会報. 96(10). 1647 (1993)

Hideo Edamatsu：“中枢听觉通路时间变性的形态学研究”日本耳鼻喉科协会通报 96(10)。

枝松 秀雄: "スナネズミの蝸牛神経核変性の聴覚系に及ぼす影響" Audiology Japan. 34(5). 511-512 (1991)

Hideo Edamatsu：“沙鼠耳蜗核变性对听觉系统的影响”日本听力学 34(5) 511-512 (1991)。

Edamatsu Hideo: "Effect of lesion in gerbil's cochlear nucleus on auditory function." Audiology Japan.34(5). 511-512 (1991)

Edamatsu Hideo：“沙鼠耳蜗核损伤对听觉功能的影响。”