Systemic Inflammatory Response Indication Observer (SIRIO)

全身炎症反应指示观察仪（SIRIO）

• 批准号: 389432072
• 负责人: Professor Dr.-Ing. Steffen Leonhardt
• 金额: --
• 依托单位: Lehrstuhl für Medizinische Informationstechnik (MedIT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/389432072?language=en
• 关键词: Systemic; Inflammatory; Response; Indication; Observer

The aim of the SIRIO project (Systemic Inflammatory Response Indication Observer) is the development of a hybrid camera monitoring system for an early detection of sepsis in premature infants. SIRIO fuses the camera-based vitalparamater monitoring systems Photoplethysmography Imaging and Infrared Imaging into a camera-based Hybrid Imaging technology for the vital state detection in neonates. Both methods are novel approaches to obtain vital parameters contactless. Hence, they can operate in addition to the existing infrastructure. A further advantage is that there is no direct contact with the patient so that the premature infant skin is not harmed. In general, the patient is not subjected to any additional stress and there is no risk of infection (caused by the measurement technique). This hybrid measuring technique allows the contactless detection of vital signs, including: 1) cutaneous blood circulation, 2) heart and respiratory rate as well as their variability, 3) the skin perfusion (central and peripheral), 4) skin coloring, and 5) physical activity.From these measured parameters, first septic indications will be automatically recognized. These septic features will be fused into a scoring parameter. This scoring parameter will be derived from the Pediatric Early Warning Score (PEWS), which is already established in the clinical routine. In case of first septic signs, an alarm is triggered, so that the next manual steps can be initiated according to the standard treatment guidelines without time loss: confirmation of the diagnosis, e.g. by checking the capillarization time, determination of blood culture and subsequent therapy.The project envisages the implementation of the hybrid monitoring concept and the development of signal processing routines, which provide a real-time decision support system for the attending clinical staff - unobtrusively and additively to the existing infrastructure at the neonatology station.For this project, the local Ethics Committee authorized a clinical human study with 20 preterm infants. Based on preclinical tests, the feasibility of this system will be proved within this study.

SIRIO 项目（系统炎症反应指示观察器）的目标是开发混合摄像头监测系统，用于早期检测早产儿败血症。 SIRIO 将基于摄像头的生命参数监测系统光电体积描记法成像和红外成像融合为基于摄像头的混合成像技术，用于新生儿生命状态检测。这两种方法都是非接触式获取生命参数的新颖方法。因此，它们可以在现有基础设施之外运行。另一个优点是不与患者直接接触，因此早产儿皮肤不会受到伤害。一般来说，患者不会承受任何额外的压力，也没有感染的风险（由测量技术引起）。这种混合测量技术可以非接触式检测生命体征，包括：1) 皮肤血液循环，2) 心率和呼吸频率及其变异性，3) 皮肤灌注（中枢和外周），4) 皮肤颜色，以及 5 ）体力活动。根据这些测量的参数，将自动识别第一个败血症迹象。这些脓毒症特征将被融合到评分参数中。该评分参数将源自临床常规中已建立的儿科早期预警评分 (PEWS)。如果出现首次败血症症状，则会触发警报，以便可以根据标准治疗指南启动接下来的手动步骤，而不会浪费时间：确认诊断，例如通过检查毛细血管化时间、血培养测定和后续治疗。该项目设想实施混合监测概念并开发信号处理例程，为主治临床工作人员提供实时决策支持系统 - 不显眼且附加的对于该项目，当地伦理委员会授权对 20 名早产儿进行临床人体研究。基于临床前测试，本研究将证明该系统的可行性。