Three dimensional mapping of turbid media by hyper spectral imaging

通过高光谱成像对浑浊介质进行三维绘图

• 批准号: 337270237
• 负责人: Professor Dr.-Ing. Michael Schmidt
• 金额: --
• 依托单位: Lehrstuhl für Photonische Technologien (LPT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/337270237?language=en
• 关键词: Three; dimensional; mapping; turbid; media

Non-invasive modalities in medical imaging diagnostics are of vital importance in order to minimize the risks for patients, particularly since many diseases necessitate repetitive imaging. Furthermore, preventing high costs from impeding regular examinations, fast and cost-efficient imaging modalities are needed. Ideally, these methods should also enable label free imaging, as labels bear potential side effects for the patients such as allergies. Furthermore, the development of suitable markers is a costly and time-consuming process. Hyperspectral imaging systems have the potential to enable fast, low-cost, non-invasive and label free imaging. Thus, they provide the opportunity to overcome all the mentioned challenges. Therefore, the goal of the planned research project is to compile and to investigate methods for the transformation of hyperspectral images into three-dimensional tissue images. Two mechanisms leading to a wavelength dependency of the penetration depth in tissue will be used for this: the wavelength dependent absorption in tissue constituents such as hemoglobin and water as well the wavelength dependent scattering behavior of the tissue. Within the scope of this project different transformation approaches are investigated and evaluated. As outcome, an optical non-invasive modality for the examination of malign near-surface tissue alterations is expected which also provides the doctor with a large field of view.Compared to established optical 3D reconstruction methods such as Optical Coherence Tomography, the new approach has the advantage of not only measuring and analyzing changes in refractive index and scattering, but also changes in absorptivity. Therefore, absorber concentration changes, such as the amount of blood in cancerous and healthy tissue or scattering concentration changes, this means the amount of scatterers in blood vessel and surrounding tissue, should be detectable. This combination of the detectability of scattering and absorber alterations and the reconstruction of the in-depth resolved images promises improved detection of malign subsurface alterations. The detection is simplified by the fact that the images of a specific depth are not convoluted with all other depths anymore. This should increase the contrast significantly and it should enable a more reliable diagnosis since possible disguises of tissue alterations are removed. Furthermore, since the imaging approach is contact free and uses standard white light sources for illumination, it will enable low-risk and inexpensive repetitive examinations of patients.

医学成像诊断中的非侵入性方式至关重要，以最大程度地降低患者的风险，尤其是因为许多疾病需要重复成像。此外，防止高昂的成本阻碍定期检查，需要快速，成本效益的成像方式。理想情况下，这些方法还应启用无标签成像，因为标签对患者（例如过敏）具有潜在的副作用。此外，合适的标记的发展是一个昂贵且耗时的过程。高光谱成像系统有可能实现快速，低成本，非侵入性和无标签成像。因此，它们提供了克服所有提到的挑战的机会。因此，计划研究项目的目标是编译和研究将高光谱图像转化为三维组织图像的方法。这两种导致组织中穿透深度的波长依赖性的机制将用于此类：组织成分中的波长依赖性吸收，例如血红蛋白和水以及组织的波长依赖性散射行为。在该项目的范围内，研究和评估了不同的转换方法。作为结果，预计将进行尼尔·近地表组织改变的光学非侵入性方式，这也为医生提供了众多的视野。不仅可以测量和分析折射率和散射的变化的优势，而且还可以在吸收性上变化。因此，吸收剂浓度的变化，例如癌和健康组织中的血液量或散射浓度的变化，这意味着应检测到血管和周围组织中的散射量。散射和吸收器改变的可检测性以及深入解析图像的重建的这种组合有望改善对恶性地下改变的检测。通过以下事实来简化检测，即特定深度的图像不再与所有其他深度卷曲。这应该显着增加对比度，并且应该可以更可靠的诊断，因为取消了组织改变的可能伪装。此外，由于成像方法是免费接触的，并使用标准的白光来源进行照明，因此它将可以对患者进行低风险和廉价的重复检查。