Elucidation of radiation resistance mechanism of oral cancer targeting PARP and creation of new treatment strategy

阐明针对PARP的口腔癌放射抵抗机制并创建新的治疗策略

• 批准号: 20K18700
• 负责人: Sakata Junki
• 金额: $ 2.66万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K18700/
• 关键词: 口腔癌; 治療抵抗性; PARP; オラパリブ; 放射線抵抗性

项目成果

BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene

BRD4通过MMP2基因的表观遗传调控促进口腔鳞状细胞癌的转移潜力

• DOI: 10.1038/s41416-020-0907-6
• 发表时间: 2020
• 影响因子: 8.8
• 作者: Yamamoto Tatsuro;Hirosue Akiyuki;Nakamoto Masafumi;Yoshida Ryoji;Sakata Junki;Matsuoka Yuichiro;Kawahara Kenta;Nagao Yuka;Nagata Masashi;Takahashi Nozomu;Hiraki Akimitsu;Shinohara Masanori;Nakao Mitsuyoshi;Saitoh Noriko;Nakayama Hideki
• 通讯作者: Nakayama Hideki

Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma

IGFBP-3 表达增强会降低放射敏感性并与口腔鳞状细胞癌的不良预后相关

• DOI: 10.3390/cancers12020494
• 发表时间: 2020
• 作者: Sakata J; Hirosue A; Yoshida R; Matsuoka Y; Kawahara K; Arita H; Nakashima H; Yamamoto T; Nagata M; Kawaguchi S; Gohara S; Nagao Y; Yamana K; Toya R; Murakami R; Kuwahara Y; Fukumoto M; Nakayama H
• 通讯作者: Nakayama H

Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma

IGFBP-3 表达增强会降低放射敏感性并与口腔鳞状细胞癌的不良预后相关

• DOI: 10.3390/cancers12020494
• 发表时间: 2020-02-01
• 期刊: Cancers
• 影响因子: 5.2
• 作者: J. Sakata;A. Hirosue;R. Yoshida;Y. Matsuoka;K. Kawahara;H. Arita;H. Nakashima;Tatsuro Yamamoto;M. Nagata;Sho Kawaguchi;Shunsuke Gohara;Yuka Nagao;K. Yamana;R. Toya;R. Murakami;Y. Kuwahara;M. Fukumoto;H. Nakayama
• 通讯作者: H. Nakayama

Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy

Onodera的预后营养​​指数与接受放化疗的口腔鳞状细胞癌患者的肿瘤免疫环境和生存相关

• DOI: 10.1016/j.tranon.2020.100850
• 发表时间: 2020
• 影响因子: 5
• 作者: Yoshida Ryoji;Gohara Shunsuke;Sakata Junki;Matsuoka Yuichiro;Hirosue Akiyuki;Kawahara Kenta;Kawaguchi Sho;Nagao Yuka;Yamana Keisuke;Nagata Masashi;Fukuma Daiki;Toya Ryo;Murakami Ryuji;Hiraki Akimitsu;Shinohara Masanori;Nakayama Hideki
• 通讯作者: Nakayama Hideki

口腔癌に対するPARP阻害剤オラパリブと抗癌剤および放射線併用効果の検討

PARP抑制剂奥拉帕尼联合抗癌药物和放射治疗口腔癌的效果研究

• 发表时间: 2021
• 作者: 坂田純基