Loss of hippocampal synapses in FTLD: autopsy-based study

FTLD 中海马突触丧失：基于尸检的研究

• 批准号: 20K16586
• 负责人: Riku Yuichi
• 金额: $ 2.58万
• 依托单位: Aichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K16586/
• 关键词: 前頭側頭型認知症; TDP-43; tau; シナプス; 筋萎縮性側索硬化症; 剖検

项目成果

Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration

进行性核上性麻痹和皮质基底节变性中的运动神经元 TDP-43 蛋白病

• DOI: 10.1093/brain/awac091
• 发表时间: 2022
• 影响因子: 14.5
• 作者: Riku Yuichi;Iwasaki Yasushi;Ishigaki Shinsuke;Akagi Akio;Hasegawa Masato;Nishioka Kenya;Li Yuanzhe;Riku Miho;Ikeuchi Takeshi;Fujioka Yusuke;Miyahara Hiroaki;Sone Jun;Hattori Nobutaka;Yoshida Mari;Katsuno Masahisa;Sobue Gen
• 通讯作者: Sobue Gen

Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

肌萎缩侧索硬化症和额颞叶变性中 TDP-43 相关病理学到神经元功能障碍的途径

• DOI: 10.3390/ijms22083843
• 发表时间: 2021
• 影响因子: 5.6
• 作者: Riku Yuichi;Seilhean Danielle;Duyckaerts Charles;Boluda Susana;Iguchi Yohei;Ishigaki Shinsuke;Iwasaki Yasushi;Yoshida Mari;Sobue Gen;Katsuno Masahisa
• 通讯作者: Katsuno Masahisa

Reappraisal of the anatomical spreading and propagation hypothesis about TDP‐43 aggregation in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

肌萎缩侧索硬化症和额颞叶变性中 TDP-43 聚集的解剖学扩散和传播假说的重新评估

• DOI: 10.1111/neup.12644
• 发表时间: 2020-03-10
• 期刊: Neuropathology
• 影响因子: 2.3
• 作者: Y. Riku

TDP-43 pathology of spinal cord in tau-related neurodegenerative disorders

tau 相关神经退行性疾病中脊髓的 TDP-43 病理学

• 发表时间: 2021
• 作者: Yuichi Riku

Reappraisal of the TDP-43 propagation hypothesis in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

肌萎缩侧索硬化症和额颞叶变性中 TDP-43 传播假说的重新评估

• 发表时间: 2020
• 作者: Yuichi Riku