Development of a novel prognostic marker for pancreatic cancer chemotherapy as an indicator of MDSC reduction due to myelosuppression.

开发一种新型胰腺癌化疗预后标志物，作为骨髓抑制导致的 MDSC 减少的指标。

• 批准号: 20K16081
• 负责人: Fujii Hironori
• 金额: $ 1.41万
• 依托单位: Gifu Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K16081/
• 关键词: 重篤な好中球減少; MDSC; がん化学療法; 生存期間; フローサイトメトリー解析; 不死時間バイアス; 時間依存性Cox回帰分析; MDSCs; 膵がん; 治療効果; 大腸がん; 切除不能進行膵がん; FOLFIRINOX療法; 好中球減少; 予後マーカー

项目成果

Anorexia, pain and peripheral neuropathy are associated with a decrease in quality of life in patients with advanced pancreatic cancer receiving outpatient chemotherapy: a retrospective observational study

厌食、疼痛和周围神经病变与接受门诊化疗的晚期胰腺癌患者的生活质量下降相关：一项回顾性观察研究

• DOI: 10.1186/s40780-021-00210-1
• 发表时间: 2021
• 影响因子: 1
• 作者: Fujii H; Koda M; Sadaka S; Ohata K; Kato
• 通讯作者: Kato

Cancer cachexia as a determinant of efficacy of first?line pembrolizumab in patients with advanced non?small cell lung cancer

癌症恶病质是一线派姆单抗治疗晚期非小细胞肺癌患者疗效的决定因素

• DOI: 10.3892/mco.2022.2524
• 发表时间: 2022-04
• 影响因子: 1.2
• 作者: Fujii H;Araki A;Iihara H;Kaito D;Hirose C;Kinomura M;Yamazaki M;Endo J;Inui T;Yanase K;Sasaki Y;Gomyo T;Sakai C;Kawae D;Kitamura Y;Fukui M;Kobayashi R;Ohno Y;Suzuki A
• 通讯作者: Suzuki A

Association of albumin-bilirubin score in patients with colorectal cancer receiving later-line chemotherapy with regorafenib.

接受瑞戈非尼后期化疗的结直肠癌患者白蛋白-胆红素评分的关联。

• DOI: 10.1007/s10147-021-01910-2
• 发表时间: 2021
• 作者: Daichi Watanabe; Hironori Fujii; Yunami Yamada; Nobuhisa Matsuhashi; Akitaka Makiyama; Hirotoshi Iihara; Takao Takahashi; Shigeru Kiyama; Ryo Kobayashi; Kazuhiro Yoshida; Akio Suzuki
• 通讯作者: Akio Suzuki

Association between the Co-administration of Histamine H2 Receptor Antagonists and the Effectiveness of Capecitabine in Patients with Colorectal Cancer: Propensity Score Analysis

组胺 H2 受体拮抗剂联合用药与卡培他滨在结直肠癌患者中的疗效之间的关联：倾向评分分析

• DOI: 10.7150/jca.73385
• 发表时间: 2022
• 影响因子: 3.9
• 作者: Yamazaki, Tomoko;Uozumi, Ryuji;Kawazoe, Hitoshi;Kitazume, Yoshiko;Iihara, Hirotoshi;Fujii, Hironori;Takahashi, Masaya;Arai, Takahiro;Murachi, Yasushi;Sato, Yumiko;Mikami, Takahiro;Hashiguchi, Koji;Yoshizawa, Tomoe;Takahashi, Katsuyuki;Fujita, Yukiyoshi;Hosokawa, Yuki;Morozumi, Issei;Tsuchiya, Masami;Yokoyama, Atsushi;Hashimoto, Hironobu;Furukawa, Tetsuya
• 通讯作者: Furukawa, Tetsuya

Impact of First-Line FOLFIRINOX-Induced Peripheral Neuropathy on the Efficacy of Second-Line GnP in Patients with Unresectable Advanced Pancreatic Cancer

一线 FOLFIRINOX 诱导的周围神经病变对二线 GnP 对不可切除的晚期胰腺癌患者疗效的影响

• DOI: 10.3390/jcm11195895
• 发表时间: 2022
• 影响因子: 3.9
• 作者: Sadaka S; Iwashita T; Fujii H; Kato
• 通讯作者: Kato