Spatial neglect and attention networks in the human brain: disturbances of functional connectivity and interhemispheric imbalance of an attentional priority map for retinotopic space

人脑中的空间忽视和注意力网络：视网膜专题空间注意力优先图的功能连接紊乱和半球间不平衡

• 批准号: 282601734
• 负责人: Privatdozent Dr. Björn Machner
• 金额: --
• 依托单位: Klinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/282601734?language=en
• 关键词: Spatial; neglect; attention; networks; human

Spatial neglect represents a severe and common cognitive disorder following unilateral (mostly right hemisphere) brain damage. Affected patients show a profound lack of awareness for the one half of space opposite to their brain lesion. Neglect counts among the strongest predictors for poor functional outcome after stroke. An established therapy is still missing. The pathophysiological base of neglect has been proposed to be an interhemispheric imbalance of an attentional priority map in the parietal lobe that is responsible for shifting attention to external stimuli in space. Whether the location of objects in such a map are mainly represented in egocentric coordinates (especially eye-centric or retinotopic) or rather allocentric coordinates (object-to-object) is unclear. The exact location of the brain lesion, that is crucial for the developement of neglect, is also a matter of ongoing debate. Recent advances in functional brain imaging, assessing the functional connectivity between multiple brain areas in global networks, seem to indicate that neglect may rather be due to a disturbance of these global attention networks and not (only) to the circumscribed structural brain damage. This project aims to tackle these open questions regarding spatial attention, the underlying behavioural and functional mechanisms as well as a potential treatment option for neglect. We will investigate healthy subjects, neurological patients with focal brain lesions (stroke patients with spatial neglect) and subjects with a transient virtual lesion in the parietal lobe, induced by transcranial magnetic stimulation (TMS). Methods include behavioural neuropsychological testing (standardized paper-pencil tests and novel computerized tasks), eye movement recordings and a gaze-contingent display technology for manipulating spatial perception and guiding the subjects gaze, and finally structural and functional magnetic resonance imaging of the brain, the latter at rest and task-related, with and without prior application of transcranial magnetic stimulation.

空间忽视是单侧（主要是右半球）脑损伤后的一种严重且常见的认知障碍。受影响的患者对其大脑病变相对的一半空间表现出严重缺乏意识。忽视是中风后功能不良的最强预测因素之一。仍然缺乏既定的治疗方法。忽视的病理生理学基础被认为是顶叶注意力优先图的半球间不平衡，该图负责将注意力转移到空间中的外部刺激。这种地图中物体的位置主要是用自我中心坐标（尤其是眼睛中心或视网膜专题）还是异中心坐标（物体到物体）来表示尚不清楚。大脑病变的确切位置对于忽视的发展至关重要，也是一个持续争论的问题。功能性脑成像的最新进展，评估全球网络中多个大脑区域之间的功能连接，似乎表明忽视可能是由于这些全球注意力网络的干扰，而不是（仅）由于有限的结构性脑损伤。该项目旨在解决有关空间注意力、潜在行为和功能机制以及忽视的潜在治疗方案等开放性问题。我们将研究健康受试者、患有局灶性脑损伤的神经系统患者（患有空间忽视的中风患者）以及经颅磁刺激（TMS）诱导的顶叶短暂性虚拟损伤的受试者。方法包括行为神经心理学测试（标准化纸笔测试和新颖的计算机化任务）、眼动记录和用于操纵空间感知和引导受试者凝视的凝视相关显示技术，最后是大脑的结构和功能磁共振成像，后者在休息和任务相关时，无论是否事先应用经颅磁刺激。

项目成果

Resting-state functional connectivity in the attention networks is not altered by offline theta-burst stimulation of the posterior parietal cortex or the temporo-parietal junction as compared to a vertex control site

• DOI: 10.1016/j.ynirp.2021.100013
• 发表时间: 2021-06
• 期刊: Neuroimage: Reports
• 作者: B. Machner;Jonathan Imholz;Lara Braun;Philip J Koch;T. Bäumer;T. Münte;C. Helmchen;A. Sprenger

Brain Activations During Optokinetic Stimulation in Acute Right-Hemisphere Stroke Patients and Hemispatial Neglect: An fMRI Study

• DOI: 10.1177/1545968319855038
• 发表时间: 2019-07-01
• 期刊: NEUROREHABILITATION AND NEURAL REPAIR
• 影响因子: 4.2
• 作者: von der Gablentz, Janina;Koenemund, Inga;Machner, Bjoern
• 通讯作者: Machner, Bjoern

Behavioral deficits in left hemispatial neglect are related to a reduction of spontaneous neuronal activity in the right superior parietal lobule

• DOI: 10.1016/j.neuropsychologia.2020.107356
• 发表时间: 2020-02-17
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Machner, Bjoern;von der Gablentz, Janina;Muente, Thomas F.
• 通讯作者: Muente, Thomas F.

Unbalancing the Attentional Priority Map via Gaze-Contingent Displays Induces Neglect-Like Visual Exploration

通过注视相关显示来平衡注意力优先级图会引发类似忽视的视觉探索

• DOI: 10.3389/fnhum.2020.00041
• 发表时间: 2020
• 期刊: Frontiers in Human Neuroscience
• 影响因子: 2.9
• 作者: Machner B;Lencer MC;Möller L;Von der Gablentz J;Heide W;Helmchen C ;Andreas Sprenger
• 通讯作者: Andreas Sprenger