1. Total Synthesis of Vinigrol Using a New Strategic Concept,2. Asymmetric Alkynyl-Substituted Trimethylenemethane [6+3] Cycloadditions,3. Total Synthesis of Bryostatin 3 Using a New Strategic Concept

1.采用新战略理念的Vinigrol全合成，2。

• 批准号: 273747462
• 负责人: Dr. Olesya Kuzmina, Ph.D.
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273747462?language=en
• 关键词: 1.; Total; Synthesis; Vinigrol; Using

In summary, we envisage a Trost asymmetric Pd-TMM reaction followed by a novel ring expansion process as the key steps to provide an efficient route to a natural product - vinigrol. Additionally, our synthetic program will examine the scope of an important class of electrocyclic reactions, namely [6+3] cycloaddition with novel TMM donors (trimethylenemethane derivatives) and acceptors, which have not been tested previously, expanding the scope of asymmetric Pd-TMM reactions. This will pave the way to a more straightforward syntheses of bioactive molecules containing bicyclic core structures. This new synthesis involving an unprecedented type of strategy will also offer the prospect of easily making analogues not available by the existing routes.

总之，我们设想 Trost 不对称 Pd-TMM 反应和新颖的扩环过程是提供天然产物维尼醇的有效途径的关键步骤。此外，我们的合成程序将检查一类重要的电环反应的范围，即与新型TMM供体（三亚甲基甲烷衍生物）和受体的[6+3]环加成反应，这些反应以前尚未测试过，从而扩大了不对称Pd-TMM的范围反应。这将为更直接地合成含有双环核心结构的生物活性分子铺平道路。这种涉及前所未有的策略类型的新合成还将提供轻松制造现有路线无法获得的类似物的前景。

项目成果

Chemoselective chromium(II)-catalyzed cross-coupling reactions of dichlorinated heteroaromatics with functionalized aryl grignard reagents.

• DOI: 10.1002/chem.201405275
• 发表时间: 2015-01
• 期刊: Chemistry
• 作者: A. Steib;O. Kuzmina;Sarah Fernandez;Sushant Malhotra;P. Knochel

Chromium(II)-Catalyzed Amination of N-Heterocyclic Chlorides with Magnesium Amides

• DOI: 10.1055/s-0034-1380178
• 发表时间: 2015-02
• 期刊: Synlett
• 影响因子: 2
• 作者: A. Steib;Sarah Fernandez;O. Kuzmina;Martin Corpet;C. Gosmini;P. Knochel

Synthesis of novel 14-membered cyclic bis-semicarbazones

新型14元环状双缩氨基脲的合成

• DOI: 10.1016/j.tetlet.2014.08.016
• 发表时间: 2014
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: Shutalev;Fesenko;Kuzmina;Chernyshev;V. V. ;Zamilatskov
• 通讯作者: Zamilatskov