I-Corps: Multiplexed Brillouin Microscopy

I-Corps：多重布里渊显微镜

• 批准号: 2401371
• 负责人: giuliano scarcelli
• 金额: $ 5万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2401371&HistoricalAwards=false
• 关键词: Corps; Multiplexed; Brillouin; Microscopy

The broader impact/commercial potential of this I-Corps project is the development of multiplexed Brillouin microscopy which introduces a new microscopy modality with a contrast that is desirable, but currently unavailable. This type of microscopy has applications in ophthalmology for refractive surgery, where current screening for at-risk patients is based on late-onset morphological metrics. Beyond the primary application in ophthalmology, the technology could offer a non-invasive approach to extracting information about morphology and chemical pathways, not mechanical properties. Mechanical information requires perturbation, often destruction, of the sample, which affects the quality of required information. Widely available Brillouin instruments could help address this gap. This I-Corps project is focused on the development of Brillouin microscopy based on spectral analysis of light scattered from a sample, which allows production of high-resolution, three-dimensional maps of the longitudinal elastic modulus of materials. Brillouin spectroscopy has been widely used for material testing and environmental sensing. In the past two decades, a new type of spectrometer has improved the speed of acquisition to enable biological applications. The Brillouin technology developed in this project can be further sped up by multiplexing the readout to many points simultaneously. This multiplexed Brillouin microscopy expands the types of potential applications of the technology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是多重布里渊显微镜的开发，它引入了一种新的显微镜模式，其对比度是理想的，但目前尚不可用。这种类型的显微镜可应用于眼科屈光手术，目前对高危患者的筛查是基于晚发形态学指标。除了眼科的主要应用之外，该技术还可以提供一种非侵入性方法来提取有关形态和化学途径（而不是机械特性）的信息。机械信息需要对样本进行扰动，通常是破坏，这会影响所需信息的质量。 广泛使用的布里渊仪器可以帮助解决这一差距。该 I-Corps 项目的重点是开发基于对样品散射光进行光谱分析的布里渊显微镜，该显微镜可以生成材料纵向弹性模量的高分辨率三维图。布里渊光谱已广泛应用于材料测试和环境传感。在过去的二十年中，新型光谱仪提高了采集速度，以实现生物应用。该项目中开发的布里渊技术可以通过同时将读数复用到多个点来进一步加速。这种多重布里渊显微镜扩展了该技术的潜在应用类型。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。