I-Corps: Sensor-based frailty assessment tool using a smart watch

I-Corps：使用智能手表的基于传感器的虚弱评估工具

• 批准号: 2413464
• 负责人: Nima Toosizadeh
• 金额: $ 5万
• 依托单位: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2413464&HistoricalAwards=false
• 关键词: Corps; Sensor; based; frailty; assessment

The broader impact/commercial potential of this I-Corps project is the development of a technology for physical frailty assessment. Frailty is an aging syndrome related to low physiological reserves in organs and systems and is associated with increased risk of hospitalization, adverse therapy outcomes, disability, and mortality. The proposed application of the technology is to risk stratify hospitalized and community dwelling older adults and will be implemented through a smartwatch and smartphone to measure frailty in under 5 minutes. Monitoring technologies, such as the proposed frailty score, have the potential to improve older people’s safety, manage their health and assist them in maintaining their independence. Additionally, these technologies hold the promise of enormous cost savings for the healthcare system by enhancing the ability of providers to provide timely intervention prior to a patient’s deterioration requiring acute care.This I-Corps project is based on the development of a novel objective sensor-based frailty assessment tool. In this frailty tool, for the first time, instead of assessing characteristics of physiological systems in basal resting-state conditions, a provocative physical stress test will be employed to quantify the level of physiological reserve within and across cardiac and motor systems. Biomechanics approaches including muscle model and heart rate dynamics analysis will be used to characterize motor and cardiac system behaviors. In addition, the proposed technology may be used to assess dynamic interactions between the motor and cardiac systems using state space reconstruction of motor and heart rate behaviors within the stress-response model. The test takes 60 seconds to perform (repetitive and fast elbow flexion) and can provide the frailty score immediately after the test. The proposed approach has been validated cross-sectionally using comprehensive frailty assessment approaches that take 45-60 minutes and longitudinally based on adverse hospital/treatment outcomes, readmission, and mortality. In addition to the sensor-based frailty score, the technology has been transformed from more expensive equipment to a simple smartwatch platform.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是开发一种用于物理脆弱评估的技术。脆弱是一种与器官和系统中物理储量低有关的衰老综合征，与住院，不良治疗结果，残疾和死亡率的增加有关。该技术的拟议应用是要使住院和社区居住的老年人风险进行分层，并将通过智能手表和智能手机实施，以在不到5分钟的时间内测量脆弱性。监测技术（例如拟议的脆弱得分）有可能提高老年人的安全，管理健康并协助他们保持独立性。此外，这些技术通过增强提供者在确定需要急性护理之前提高提供者提供及时干预的能力来节省大量成本的承诺。此I-Corps项目基于开发一种新型的基于目标传感器的脆弱评估工具。在这个脆弱的工具中，首次将采用挑衅性的物理压力测试来量化心脏和运动系统内部和整个心脏系统内物理储备水平，而不是评估物理系统的特征。包括肌肉模型和心率动态分析在内的生物力学方法将用于表征运动和心脏系统行为。此外，提出的技术可用于使用压力反应模型中运动和心率行为的状态空间重建运动和心脏系统之间的动态相互作用。该测试需要60秒才能执行（重复和快速肘部屈曲），并且可以在测试后立即提供脆弱的分数。拟议的方法已通过全面的脆弱评估方法在横截面上进行了验证，该方法需要45-60分钟，并根据不良的医院/治疗结果，再入院和死亡率进行纵向审查。除了基于传感器的脆弱得分外，该技术还从更昂贵的设备转变为简单的智能手表平台。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被视为通过评估来获得珍贵的支持。