CAREER: Collective hydrodynamics within viscous interfaces: activity and assembly in membranes and monolayers

职业：粘性界面内的集体流体动力学：膜和单层中的活性和组装

• 批准号: 2340415
• 负责人: Harishankar Manikantan
• 金额: $ 55.16万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-02-01 至 2029-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2340415&HistoricalAwards=false
• 关键词: CAREER; Collective; hydrodynamics; within; viscous

The cooperative movement of microscopic particles embedded in the interface between two fluids is central to many biological and engineering processes. These dynamics govern the motion of proteins in cell membranes or respiratory particulate matter on lung linings and in-fluence the design of synthetic drug delivery vehicles that mimic natural cells. This award will support the development of new models and simulations to quantify and engineer these complex membrane-like assemblies. This project will describe the activity and dynamics of particles of realistic shapes, develop accurate simulations to efficiently characterize large-scale aggregates, and reveal novel strategies to engineer interactions between particles. In a tightly integrated education plan, this project will develop a cohort program specifically targeting the professional success and STEM participation of underrepresented transfer students from local community colleges via year-long mentorship and training. As part of this program, researchers and trainees will develop and disseminate open-source, interactive, instruction modules for teachers and students, aimed at promoting broad engagement with coding and engineering methods and inspiring a more competitive future STEM workforce. The main goal of this award is to firmly establish the role of large-scale hydrodynamic interactions on particle organization within viscous interfaces in a broad class of biological and biomimetic applications. While the transport of isolated, passive particles in Newtonian interfaces is well established, a rigorous platform to capture large-scale hydrodynamic interactions of realistic particle shapes in complex crowded monolayers or membranes that represent many applications is still lacking. Real systems are particularly challenging due to non-Newtonian surface rheology, the active nature of molecular motors and artificial self-propelled interfacial colloids, and the extended or deformable structure of membrane anchors and synthetic nano-rods. This project will use asymptotic theory to systematically evaluate pair interactions in a wide range of realistic non-Newtonian interfaces, develop efficient computational methods to capture large-scale surface hydrodynamics, extend these insights and tools to complex particle shape and system geometries, and develop mesoscopic mean-field models to explore large-scale structure, stability, and patterns. Put together, the analytical and numerical tools developed in this project will be broadly applicable in the rational and creative design of novel self-assembled materials on bilayers, monolayers, biofilms, and polymer membranes, going beyond the length scales and limitations of traditional interfacial engineering.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

两种流体之间嵌入在界面中的微观颗粒的合作运动对于许多生物学和工程过程至关重要。这些动力学控制了蛋白质在细胞膜中的运动或呼吸颗粒物在肺部衬里上的运动，并在含量的纯度设计模仿天然细胞的合成药物递送车的设计。该奖项将支持开发新模型和模拟，以量化和设计这些复杂的膜般的组件。该项目将描述逼真形状的颗粒的活性和动力学，开发准确的模拟以有效地表征大型聚集体，并揭示粒子之间工程相互作用的新型策略。在一项紧密融合的教育计划中，该项目将制定一项队列计划，专门针对专业的成功和STEM参与不足的转学学生，通过为期一年的指导和培训，来自当地社区学院的代表性不足。作为该计划的一部分，研究人员和学员将为教师和学生开发和传播开放源代码，互动，指导模块，旨在促进与编码和工程方法的广泛参与，并激发更具竞争力的未来STEM劳动力。该奖项的主要目的是在广泛的生物学和生物模仿应用中牢固确定粘性界面中粒子组织中大规模流体动力相互作用的作用。虽然已经建立了牛顿界面中孤立的，被动的颗粒的运输，但在复杂的拥挤的单层或膜上捕获逼真的粒子形状的大规模流体动力相互作用的严格平台仍然缺乏许多应用。由于非牛顿表面流变学，分子电动机和人工自行界面胶体的主动性以及膜锚和合成纳米棒的扩展或可变形结构，实际系统尤其具有挑战性。该项目将使用渐近理论在各种逼真的非牛顿界面中系统地评估配对的相互作用，开发有效的计算方法来捕获大规模的表面水动力学，将这些见解和工具扩展到复杂的粒子形状和系统的几何形状，并发展为中学的几何形状，并发展。平均场模型探索大规模结构，稳定性和模式。综上所述，该项目开发的分析和数值工具将广泛地适用于双层，单层，生物膜和聚合物膜的新型自组装材料的理性和创意设计，超出了传统界面工程的长度尺度和限制该奖项反映了NSF的法定任务，并通过使用基金会的智力优点和更广泛的影响审查标准来评估值得支持。