NSF-BSF: Dynamics of flowing particles in soft confined systems

NSF-BSF：软约束系统中流动粒子的动力学

• 批准号: 2328628
• 负责人: Bhargav Rallabandi
• 金额: $ 33.6万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2328628&HistoricalAwards=false
• 关键词: NSF; BSF; Dynamics; flowing; particles; NSF; BSF; Dynamics; flowing; particles

This award will investigate how particles flow in complex compliant microscale systems, in which deformation of either the particles or the confining environment affects particle transport. Many biological and engineered structures at the microscale, such as cell membranes, biofilms, and microfluidic devices, are soft and thus easily deformed by fluid flow. Red blood cells deform when flowing in narrow capillaries, and swimming microbes and flowing microparticles can cause cell membranes to bend and deform. These deformations modify the motion of the suspended entities (e.g., cells or microorganisms) as a result of interactions with the carrying fluid. The project will quantify these interaction mechanisms, which are important to understand microscale biological transport, and to build biomimetic systems that use compliant structures to manipulate suspensions of particles or cells for biomedical applications. Furthermore, this award will foster education and outreach activities by engaging, or exposing undergraduate and graduate students, as well as middle and high-school teachers, to its research. As a collaboration between the University of California, Riverside and Tel Aviv University, it will also serve to enhance the participation of under-represented groups, including women, in both Riverside County and Tel Aviv (Israel).This award will investigate the dynamics of particulate suspensions confined by flexible elastic membranes, which are ubiquitous in biological environments at the microscale. The researchers will develop a fundamental understanding of hydroelastic mechanisms of suspension transport in microscale systems, using a combination of analytic theory, numerical simulations, and experiments. Over the course of the project, the international team will develop (i) novel theoretical and reduced-order models of hydroelastic interactions between particles near membranes, (ii) a new nonlinear hydroelastic mobility framework, complemented by numerical simulations, of many-particle dynamics in proximity to membranes, and (iii) new experimental studies to visualize, characterize, and quantify particle-membrane interactions in macroscopic and microscopic settings. Finally, the fundamental insights obtained from these studies will be used to develop a microfluidic device to manipulate and sort vesicles and soft particles based on their mechanical and geometric properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项将调查颗粒在复杂的符合符合符合的显微镜系统中的流动方式，其中颗粒或限制环境的变形会影响颗粒的传输。微观尺度上的许多生物和工程结构，例如细胞膜，生物膜和微流体设备，都是柔软的，因此很容易被流体流动变形。红细胞在狭窄的毛细血管中流动时变形，游泳微生物和流动的微粒会导致细胞膜弯曲和变形。这些变形改变了悬浮实体（例如细胞或微生物）的运动，这是由于与携带液的相互作用而导致的。该项目将量化这些相互作用机制，这些机制对于了解微观生物运输非常重要，并建立使用兼容的结构来操纵颗粒或细胞的悬浮液进行生物医学应用。此外，该奖项将通过参与或揭露本科和研究生以及中学和高中老师来促进教育和外展活动。作为加利福尼亚大学，河滨大学和特拉维夫大学之间的合作，它还将有助于增强代表性不足的群体的参与，包括妇女在河滨县和特拉维夫（以色列）（以色列）。该奖项将调查由柔性弹性膜所限制的颗粒性悬浮液的动态，这些弹性膜受到柔和环境，在生物学环境中占据了微观的微观科学环境。研究人员将使用分析理论，数值模拟和实验的组合，对微观系统中悬浮液传输的水力弹性机制产生基本理解。在项目的过程中，国际团队将开发（i）膜附近粒子之间的水力弹性相互作用的新型理论和减少阶段模型，（ii）一个新的非线性水力弹性迁移率框架，由数值模拟，由数值模拟，通过与膜相关性的多个粒子动力学的数值模拟进行补充，并具有新的实验性研究，并绘制了新的实验性研究，并列出了新的实验，并描述了可视化和可视化和可视化和可视化和可视化和可视化和可视化的特征，并以可视化和可视化的方式来描述和可视化的界面化，并以可视化和可视化的方式来描述，并以可视化和可视化的方式来描述，并以可视化的方式和可视化界面化，并具有可视化的界面化，并具有可视化的界面。宏观和微观环境。最后，从这些研究中获得的基本见解将用于开发微流体设备，以基于其机械和几何特性来操纵和排序囊泡和软颗粒。该奖项反映了NSF的法定任务，并被认为是通过该基金会的知识分子和更广泛的影响来评估的支持，并被视为值得通过评估的支持。