Conference: Stem Cells, Cell Therapy and Bioengineering in Lung Biology and Diseases 2023

会议：肺生物学和疾病中的干细胞、细胞治疗和生物工程 2023

• 批准号: 2327935
• 负责人: Amy Ryan
• 金额: $ 1.38万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2327935&HistoricalAwards=false
• 关键词: Conference; Stem; Cells; Cell; Therapy

The 10th Stem Cells, Cell Therapy and Bioengineering in Lung Biology and Diseases Conference will be held 17-20 July 2023, at the University of Vermont in Burlington, which has been the venue of all of the conferences since the biannual series began in 2005. The conference fills an important niche in the rapidly moving fields of stem cells, cell therapies, lung biology, and bioengineering. In addition to stimulating extensive discussion and debate by international leaders and up and coming investigators and trainees, an important deliverable is a set of guidelines for basic and translational research to be utilized by both investigators and funding agencies. As in previous years, junior investigators, trainees, and investigators from underrepresented groups will be prioritized for inclusion in conference organization, oral presentations, chairing activities, discussions, and poster sessions. In 2023, an exciting new High School STEM Experience will be introduced to foster the next generation of scientists by providing on opportunity for participants to engage with scientific faculty and trainees from around the world and further gain experience with state-of-the-art scientific techniques.Repair and regeneration of a diseased lung with stem cells or bioengineered tissues are exciting potential therapeutic approaches for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence in preclinical models suggests that cells which are not normally resident in the lung, notably mesenchymal stromal cells (MSCs) can be utilized to modulate immune responses after injury, but there have been challenges in translating these promising findings to the clinic. In parallel, there has been a surge in bioengineering studies investigating use of artificial and acellular lung matrices as scaffolds for three-dimensional lung or airway regeneration, with some recent attempts of transplantation in large animal models. The combination of these studies with those utilizing stem cells, induced pluripotent stem cell derivatives, and/or cell therapies is a promising and rapidly developing research area. These studies have been further paralleled by significant increases in understanding the molecular and cellular events by which endogenous lung stem and/or progenitor cells arise and differentiate during lung development and in normal and pathologic repair and remodeling after lung injury. For the 2023 conference, scientific symposia have been chosen to reflect the most cutting-edge advances in the field and will include sessions focusing on the integration of omics with function, the role of the extracellular matrix, and the influence of immune cells on lung repair and regeneration. These cutting edge basic and translational science studies are rapidly enhancing fundamental understanding of lung repair and regeneration and the planned conference will continue to help shape further progress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

肺部生物学和疾病中的第10个干细胞，细胞治疗和生物工程会议将于2023年7月17日至20日在伯灵顿的佛蒙特大学举行，自2005年双年度系列以来，该会议一直是所有会议的场所。该会议在会议上填补了迅速移动的干细胞生物的重要性。除了刺激国际领导人以及即将到来的调查人员和受训者的广泛讨论和辩论外，重要的可交付是研究人员和资助机构都将利用基础和转化研究的一系列准则。与往年一样，来自代表性不足的团体的初级调查人员，学员和调查人员将优先考虑将会议组织，口头演讲，主席活动，讨论和海报会议纳入。在2023年，将引入一种令人兴奋的新高中STEM经验，以促进下一代科学家，从而为参与者提供与来自世界各地的科学教师和学员互动的机会，并进一步获得最先进的科学技术的经验。对肺部或生物工程组织的肺部或生物引起的疾病的疾病或生物引起的疾病的疾病和疾病的疾病和疾病的疾病疾病和多种疾病的疾病，疾病细胞的疾病细胞和疾病的疾病是多种多样的疾病。在过去的十年中，临床前模型中越来越多的证据表明，通常在肺中居住的细胞，尤其是间充质基质细胞（MSC）可用于调节受伤后的免疫反应，但在将这些有希望的发现转化为临床方面存在挑战。同时，生物工程研究的激增，调查了人工和细胞肺矩阵作为三维肺或气道再生的支架，并在大型动物模型中进行了一些移植尝试。这些研究与利用干细胞，诱导多能干细胞衍生物和/或细胞疗法的研究的结合是一个有前途且迅速发展的研究领域。这些研究在理解分子和细胞事件方面的显着增加而与内源性肺茎和/或祖细胞的显着增加相似，并在肺发育过程中以及在肺损伤后的正常和病理修复和重塑中出现并分化。在2023年会议上，已经选择了科学专题讨论会来反映该领域的最前沿进步，并将包括关注OMICS与功能的整合，细胞外基质的作用以及免疫细胞对肺修复和再生的影响。这些最先进的基础和转化科学研究正在迅速增强对肺修复和再生的基本理解，而计划的会议将继续有助于取得进一步的进步。该奖项反映了NSF的法定任务，并认为值得通过基金会的知识分子优点和更广泛的影响审查标准通过评估来获得支持。