eMB: Collaborative Research: Fluid Dynamics and Infectious Diseases: An Integrated Modeling Framework

eMB：协作研究：流体动力学和传染病：集成建模框架

• 批准号: 2324692
• 负责人: Libin Rong
• 金额: $ 15万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2324692&HistoricalAwards=false
• 关键词: eMB; Collaborative; Research; Fluid; Dynamics

Emerging and reemerging infectious diseases pose significant threats to public health worldwide. Despite extensive research and control efforts for these diseases, the understanding of the complex mechanisms behind their emergence and spread remains limited at present. This project aims to advance the knowledge of infectious diseases using an innovative approach based on fluid dynamics. The insights obtained from this research have the potential to enhance disease prevention and intervention strategies, improve therapeutic treatment, and inform epidemic/pandemic management practices. The project is a collaboration between the University of Tennessee at Chattanooga and the University of Florida and offers valuable educational and outreach opportunities. It will engage students from math and engineering backgrounds at the two institutions, providing them with research training at the intersection of applied math, fluid dynamics, public health, and computational science. The project will also place a special emphasis on recruiting and supporting students from underrepresented groups, promoting diversity in the field. The major goal of this project is to develop an innovative mathematical and computational modeling framework that integrates fluid dynamics and infectious diseases across multiple scales. This innovative framework represents a cutting-edge approach in infectious disease research. The proposed research will address the spatial spread of infectious diseases at the population level, explore the interactions between pathogens and individual hosts within the human body, and establish connections between disease dynamics at different scales. The research tasks involve the application of computational fluid dynamics, infectious disease modeling at both the within-host and population levels, and multi-scale modeling with high-performance computation. By leveraging these methodologies, the project seeks to gain a deeper understanding of the pathogenesis, transmission, and propagation of infectious diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

新兴和重新出现的传染病对全球公共卫生构成了重大威胁。尽管对这些疾病进行了广泛的研究和控制工作，但目前对它们出现和传播背后的复杂机制的理解仍然有限。该项目旨在使用基于流体动力学的创新方法来促进传染病的知识。从这项研究中获得的见解具有增强疾病预防和干预策略，改善治疗治疗并为流行病/大流行管理实践提供的潜力。该项目是田纳西大学查塔努加大学与佛罗里达大学之间的合作，并提供了宝贵的教育和外展机会。它将吸引来自两个机构的数学和工程背景的学生，为他们提供在应用数学，流体动力学，公共卫生和计算科学的交集的研究培训。该项目还将特别强调来自代表性不足的团体的招募和支持学生，从而促进该领域的多样性。该项目的主要目标是开发创新的数学和计算建模框架，该框架整合了多个尺度上的流体动力学和传染病。这个创新的框架代表了传染病研究中的尖端方法。拟议的研究将解决传染病水平上传染病的空间传播，探索病原体与人体中各个宿主之间的相互作用，并在不同尺度上建立疾病动力学之间的联系。研究任务涉及计算流体动力学，宿主内部和人口水平的传染病建模以及具有高性能计算的多尺度建模。通过利用这些方法，该项目试图更深入地了解传染病的发病机理，传播和传播。该奖项反映了NSF的法定任务，并被认为值得通过基金会的知识分子优点和更广泛的影响来通过评估来获得支持。