CAREER: Water-Soluble Metallofullerene Derivatives with Defined Structures and Tailorable Functions

职业：具有明确结构和可定制功能的水溶性金属富勒烯衍生物

• 批准号: 2238629
• 负责人: Jianyuan Zhang
• 金额: $ 70万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2238629&HistoricalAwards=false
• 关键词: CAREER; Water; Soluble; Metallofullerene; Derivatives

WIth support from the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program of the Division of Chemistry, Jianyuan Zhang of Rutgers, The State University of New Jersey and his team will synthesize and structurally characterize water soluble endohedral metallofullerenes (EMFs) and explore their potential utility. EMFs are nanometer-sized soccer ball-shaped carbon molecules that encapsulate metal ions within their cages. Electronic, energy, quantum materials, catalysis, electronics, and biotechnologies are potential applications where EMFs show promise. However, realizing their full potential will require a better understanding of their behavior in aqueous solution. Typical approaches to making water-soluble EMF derivatives do not yield structurally defined molecules; they invariably disrupt the structure of the EMF cage and downgrade its electronic properties. This project will use a modular synthetic approach to create a family of water-soluble EMFs with precisely defined structures and study the correlation between their structural parameters and electro-optic properties. In the course of conducting this project, students will be trained in a multidisciplinary research environment. Active learning techniques with real world experiments that are integrated with the research results will be developed. Outreach activities targeting a diverse population in local community colleges will be carried out to introduce economically disadvantaged and underrepresented students future career paths in science.This project will utilize a modular “metallobuckytrio” (MBT) platform that was recently developed in the laboratory of the principal investigator. The MBT platform, which consists of two metallofullerenes covalently bonded to one C60 fullerene, allows the synthesis of a family of structurally defined water-soluble EMF derivatives with desirable properties via judicious selection of ligands. Three research aims will be pursued. In Aim 1, saccharide-functionalized ligands will be introduced to enhance the T1 relaxivity of gadolinium (Gd) MBTs for the next-generation MRI contrast agents. In Aim 2, porphyrin-functionalized ligands will be introduced and photo-induced charge separation and recombination processes of the resulting porphyrin-fullerene tridecads will be investigated. In Aim 3, dye-functionalized ligands will be introduced to form synergistic photosensitizers with potential long term scientific impact in photodynamic therapy (PDT).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系高分子、超分子和纳米化学（MSN）项目的支持下，新泽西州立大学罗格斯大学的张建元及其团队将合成水溶性内嵌金属富勒烯（EMF）并进行结构表征，并探索其潜力EMF 是纳米大小的足球形状的碳分子，将金属离子封装在其笼子内。催化、电子和生物技术是 EMF 显示出前景的潜在应用，但要充分发挥其潜力，需要更好地了解其在水溶液中的行为。该项目将使用模块化合成方法来创建一系列具有精确定义结构的水溶性电磁场，并研究其结构参数和电光之间的相关性。在开展该项目的过程中，学生将在多学科研究环境中接受培训，并结合现实世界的实验，在当地社区学院开展针对不同人群的推广活动。该项目将利用首席研究员实验室最近开发的模块化“metalobuckytrio”（MBT）平台，该平台由两个金属富勒烯组成。共价键合到一个 C60 富勒烯上，通过明智地选择配体，可以合成一系列具有所需特性的结构明确的水溶性 EMF 衍生物。在目标 1 中，将引入糖功能化配体来增强。用于下一代 MRI 造影剂的钆 (Gd) MBT 的 T1 弛豫率 在目标 2 中，将引入卟啉功能化配体并进行研究。将研究由此产生的卟啉-富勒烯三十化合物的光诱导电荷分离和重组过程。在目标 3 中，将引入染料功能化配体以形成对光动力疗法 (PDT) 具有潜在长期科学影响的协同光敏剂。通过使用基金会的智力价值和更广泛的影响审查标准进行评估，NSF 的法定使命被认为值得支持。