MRI: Track 3 Acquisition of Helium Recovery Equipment at West Virginia University

MRI：第 3 轨道采购西弗吉尼亚大学氦回收设备

• 批准号: 2320495
• 负责人: Terry Gullion
• 金额: $ 30.1万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320495&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Helium; Recovery

This award is jointly supported by the Major Research Instrumentation, the Chemistry Research Instrumentation programs, and the Established Program to Stimulate Competitive Research in response to the solicitation of proposals that promote the recovery, recycle, and/or reuse of helium, which was initiated by the CHIPS and Science Act of 2022. West Virginia University is acquiring a helium recovery system to capture and reliquefy helium from five NMR spectrometers to support the research of Professor Terry Gullion along with colleagues Gregory Dudley, Brian Popp, Jessica Hoover, and Carsten Milsmann. This equipment supports research in the areas of synthetic organic and inorganic chemistry, medicinal and structural biochemistry, physical organic chemistry, and NMR methodology development. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. Using the intrinsic magnetic properties of atomic nuclei, it is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The superconducting magnets of these instruments rely on regular deliveries of liquid helium to maintain their operation. However, the instability in the helium supply due to global and national challenges jeopardizes research programs relying on NMR spectroscopy. A helium recovery system collects the helium boiloff from the superconducting magnets of NMR spectrometers and then reliquefies the helium for reuse. This equipment supports the educational, research, and teaching efforts of students, including undergraduates from groups underrepresented in STEM and first-generation students, at all levels in multiple departments and the surrounding community. This award is aimed at supporting research and education at all levels. Specifically, this helium recovery system collects the helium boiloff for reliquefication and reuse from the superconducting magnets which sustains the operation of the institution’s five NMR spectrometers. The NMR instrumentation supported by this equipment enables research projects focused on chemical synthesis and methodology, medicinal chemistry, and reaction technology development. The research supported also involves the development and mechanistic study of catalytic oxidation reactions and sustainable (photo)chemistry with earth-abundant metals. Additionally, the recovery system aids in supporting investigations focusing on the methodology development and optimization using organometallic catalysis and the development of protein-protein interaction inhibitors. Other research areas include the development of new MRI contrast agents and single molecule magnets, NMR methodology development, and the characterization of insect wing membranes using solid-state NMR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具，化学研究工具计划以及启发竞争性研究的既定计划共同支持，以响应促进促进培养的建议，这些建议是由2022年的Chips and Science启动的，这是由2022年的Chips and Science启动的。 Gullion与同事Gregory Dudley，Brian Popp，Jessica Hoover和Carsten Milsmann。该设备支持合成有机和无机化学，医学和结构生物化学，物理有机化学和NMR方法论开发领域的研究。核磁共振（NMR）光谱是化学家使用的最强大的工具之一，用于使用原子核的固有磁性特性，用于识别未知物质，用于表征分子内原子的特定布置，并研究溶液中分子或固态之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。这些仪器的超导磁铁依赖于定期输送液态氦气以保持其运行。然而，由于全球和国家挑战引起的氦气供应的不稳定危害了依赖NMR光谱的研究计划。氦恢复系统从NMR光谱仪的超导磁体中收集氦沸腾，然后重新将氦重新使用以重复使用。该设备支持学生的教育，研究和教学工作，包括在STEM和第一代学生中代表不足的团体的本科生，在多个部门和周围社区的各个层面。该奖项旨在支持各级研究和教育。具体而言，该氦回收系统收集了氦气沸腾，以使其重新置换并从超导磁铁中重复使用，从而维持机构五个NMR光谱仪的运行。该设备支持的NMR仪器使研究项目侧重于化学合成和方法论，药物化学和反应技术开发。支持的研究还涉及对催化氧化反应和可持续性（照片）化学的开发和机械研究。此外，恢复系统有助于使用有机催化催化剂和蛋白质 - 蛋白质相互作用抑制剂的开发，以支持研究方法开发和优化。其他研究领域包括开发新的MRI对比剂和单分子磁铁，NMR方法论的开发以及使用固态NMR的昆虫翼膜的表征。该奖项反映了NSF的法定任务，并通过使用基金会的知识分子和更广泛的影响审查标准来通过评估来诚实地通过评估来诚实地支持。