Discovering How Stress Induced Histomorphogenesis Effects the Long-term Leaching from an Implanted Medical Device using Phase Field Models

使用相场模型发现应力诱导的组织形态发生如何影响植入医疗器械的长期浸出

• 批准号: 2309538
• 负责人: Martin Tanaka
• 金额: $ 19.98万
• 依托单位: Western Carolina University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2309538&HistoricalAwards=false
• 关键词: Discovering; How; Stress; Induced; Histomorphogenesis; Discovering; How; Stress; Induced; Histomorphogenesis

This project will use computer simulations to better understand the effects of a medical implant on the surrounding tissue. Many people benefit from implanted medical devices to restore body function caused by injury, disease, cancer, or aging. Plastics and other polymers are commonly used in hip implants, knee implants, and coatings around these devices. This could cause harm if potentially hazardous chemicals within them leach into the body. Existing computer simulations can be used to predict the amount of material released from a device for short-term exposure. However, these models cannot accurately capture long-term exposure because they do not consider changes in the tissue that occur during the healing process. This award supports fundamental research to provide knowledge needed to generate computer simulations that account for tissue changes near an implanted device. Outcomes include developing a better understanding of how these changes impact tissue permeability and may contribute to the assessment of the risk posed by medical devices. In addition, this research will further enhance our understanding of transport properties in biological tissue, support three high priority regulatory science projects, and provide undergraduates with funded research opportunities.Phase field modeling is a powerful technique that can be used to model heterogeneous materials that change phase over space and time. The characteristics of an individual element are identified by field parameters that enable individual elements to evolve over time, giving a single model the ability to effectively capture complex time-dependent behavior. It was selected for this study because of its ability to model the transformation of tissue from regular preimplantation phenotypes to fibrous and avascular tissue associated with the foreign body capsule. Because the element characteristics are controlled by the field and not permanently associated with specific elements, the boundary location between different tissue phenotypes can move as healing progresses and a single-phase field model can capture both the histomorphological changes and the biotransport properties of the system through the entire duration of the healing process. This work will be the first application of phase field modeling to characterize the evolution of the complex heterogeneous tissue structure surrounding an implanted medical device. Furthermore, it will also be the first model that quantifies the release of leachable chemicals by an implant through heterogeneous tissues.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将使用计算机模拟更好地了解医疗植入物对周围组织的影响。 许多人从植入的医疗设备中受益，以恢复受伤，疾病，癌症或衰老引起的身体功能。塑料和其他聚合物通常用于这些设备周围的髋植入物，膝盖植入物和涂料中。如果内部潜在的危险化学物质浸入体内，这可能会造成伤害。现有的计算机模拟可用于预测从设备中释放的材料量，以进行短期暴露。但是，这些模型无法准确捕获长期暴露，因为它们不考虑在愈合过程中发生的组织中发生变化。该奖项支持基本研究，以提供所需的知识，以生成计算机模拟，以说明植入设备附近的组织变化。结果包括更好地了解这些变化如何影响组织的渗透性，并可能有助于评估医疗设备带来的风险。 此外，这项研究将进一步增强我们对生物组织中的运输特性的理解，支持三个高优先级监管科学项目，并为大学生提供资助的研究机会。《阶段现场建模》是一种强大的技术，可用于模拟异构材料，这些材料会改变超时和时间的变化阶段。单个元素的特征是通过字段参数识别的，这些字段参数使各个元素能够随着时间的流逝而发展，从而使单个模型具有有效捕获复杂的时间相关行为的能力。之所以选择这项研究，是因为它能够模拟组织从常规植入前表型转变为与异物囊相关的纤维和血管组织的转化。由于元素特征由场地控制，而不是与特定元素永久关联，因此随着愈合的进展，不同组织表型之间的边界位置可以移动，并且单相模型可以通过整个愈合过程来捕获系统的组织形态变化和系统的生物转移特性。这项工作将是相位场建模的第一个应用，以表征围绕植入医疗设备的复杂异质组织结构的演变。此外，这也将是第一个通过异质组织量化植入物释放可浸出化学物质的模型。该奖项反映了NSF的法定任务，并认为使用基金会的智力优点和更广泛影响的审查标准，认为通过评估值得通过评估值得支持。