Conference: Coordinating the development of self-disseminating vaccines for spillover prevention

会议：协调自传播疫苗的开发以预防溢出

• 批准号: 2216790
• 负责人: Scott Nuismer
• 金额: $ 7.17万
• 依托单位: Regents of the University of Idaho
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216790&HistoricalAwards=false
• 关键词: Conference; Coordinating; development; self; disseminating

A workshop will be held in Portland, Oregon to consider the issues concerning the development of a transmissible vaccine. Spillover of zoonotic pathogens has proven difficult to control and virtually impossible to eliminate. Although animal vaccination programs using standard methods have reduced the burden of spillover in some cases (e.g., rabies, brucellosis), other regions endure continued spillover because logistical and financial challenges make delivering large quantities of vaccine to wild and domestic animal populations impractical. A novel solution to this problem is the transformation of benign, naturally-occurring viruses into into vaccines capable of self dissemination, i.e., transmissible vaccines. A growing body of theory shows that vaccine transmission makes it possible to eliminate the risk of spillover from hard to reach and difficult to vaccinate animal populations at a fraction of the cost that would be required via traditional one vaccine-one host vaccination campaigns. Such vaccines are increasingly feasible to generate in the laboratory, but many technical challenges and unresolved questions underpin their safe and effective implementation in natural systems. This workshop will coordinate the development of transmissible vaccines by bringing together immunologists, vaccine engineers, virologists, disease ecologists, evolutionary biologists, and mathematical modelers. An important goal of the workshop will be to increase the diversity of the community working on this emerging technology, with a specific focus on increasing the representation of early career scientists, women, and scientists from lower middle-income countries where the technology may have the most immediate positive impacts on human health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

研讨会将在俄勒冈州波特兰举行，审议有关开发传染性疫苗的问题。事实证明，人畜共患病病原体的溢出很难控制，而且几乎不可能消除。尽管使用标准方法的动物疫苗接种计划在某些情况下（例如狂犬病、布鲁氏菌病）减轻了溢出负担，但其他地区仍承受着持续的溢出负担，因为后勤和财务挑战使得向野生和家养动物群体提供大量疫苗不切实际。解决这个问题的一个新方法是将良性的、自然存在的病毒转化为能够自我传播的疫苗，即传染性疫苗。越来越多的理论表明，疫苗传播可以消除因难以到达和难以接种疫苗的动物种群而造成的溢出风险，而成本只是传统的一疫苗一宿主疫苗接种活动所需成本的一小部分。此类疫苗在实验室中生产的可行性越来越高，但许多技术挑战和未解决的问题支撑着它们在自然系统中安全有效的实施。该研讨会将汇集免疫学家、疫苗工程师、病毒学家、疾病生态学家、进化生物学家和数学建模者，协调传染性疫苗的开发。研讨会的一个重要目标是增加从事这一新兴技术的社区的多样性，特别关注增加早期职业科学家、女性和来自该技术可能拥有的中低收入国家的科学家的代表性。对人类健康最直接的积极影响。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。