Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
基本信息
- 批准号:2244996
- 负责人:
- 金额:$ 8.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The failure of the right ventricle can indicate a higher risk of mortality in diseases like pulmonary hypertension and heart failure with preserved ejection fraction. People with these diseases often report exercise intolerance, which suggests that their response to physical stress is impaired. This research project aims to improve our understanding of the mechanical behavior of the right ventricle and how it affects its pumping function. The concept of viscoelasticity, which refers to the immediate (elastic) and delayed (viscous) resistance of cardiac tissue during contraction and relaxation, will be used to study how cellular behavior and the overall performance of the heart are affected. The research will include a comprehensive analysis of the viscoelasticity of the right ventricle tissue and its implications in organ function. The findings of this study could be used to the care and management of approximately 6.7 million heart failure patients, which are projected to increase with the aging population. The research team plans to engage young minds and advance the education of the next generation of bioengineers, with a focus on mentoring women and first-generation students to enhance diversity in the STEM workforce.The aim of the research is to discover how the ventricle wall viscoelastic properties change under acute stress and chronic pulmonary hypertension and impact organ function. To characterize the tissue biaxial viscoelasticity with disease progression and at varied heart rates, the passive viscoelasticity of the right ventricle will be measured experimentally by stress relaxation and cyclical tensile tests and simulated computationally with our validated models. To reveal the cellular and extracellular components’ contributions to tissue viscoelasticity, drug treatment will be performed to depolymerize microtubules and degrade collagen and changes in tissue viscoelasticity will be quantified. A new multiscale constitutive model will be developed to predict the viscoelasticity of myofibers and collagen as well as collagen recruitment. Finally, organ function changes will be measured with right ventricle viscoelasticity altered by chronic hypertension and acute stress. Educational activities include the distribution of various STEM kits to elementary and middle-to-high school students in northern Colorado, participation in existing K-12 public outreach events on campus. Additionally, there will be training and mentoring of underrepresented undergraduate and graduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
右心室的失败可能表明诸如肺动高压和心力衰竭的疾病中死亡的风险更高,并保留了射血分数。患有这些疾病的人经常报告运动肠,这表明他们对身体压力的反应受到损害。该研究项目旨在提高我们对右心室机械行为及其如何影响其抽水功能的理解。粘弹性的概念是指在收缩和放松期间心脏组织的直接(弹性)和延迟(粘性)耐药性,将用于研究细胞行为和心脏的整体表现如何受到影响。该研究将包括对右通气组织的粘弹性及其对器官功能的影响的全面分析。这项研究的发现可用于大约670万心力衰竭患者的护理和管理,这些患者预计随着老龄化的人口而增加。研究团队计划吸引年轻人的思想并推进下一代生物工程师的教育,重点是使妇女和第一代学生进行心理化,以增强STEM劳动力的多样性。该研究的目的是发现通风壁粘弹性特性在急性压力下如何变化,并在急性肺部高血压和持续性高血压和影响器官功能下发生变化。为了表征通过疾病进展和心率变化的组织双轴粘弹性,右通气的被动粘弹性将通过应力放松和周期性拉伸测试进行实验测量,并通过我们经过验证的模型在计算上进行计算。为了揭示细胞和细胞外成分对组织粘弹性的贡献,将进行药物治疗以解聚微管和降解胶原蛋白,并将量化组织粘弹性的变化。将开发一个新的多尺度构成模型,以预测肌纤维和胶原蛋白以及胶原蛋白招募的粘弹性。最后,将通过透镜高血压和急性应激改变的右通气粘弹性来测量器官功能变化。教育活动包括在科罗拉多州北部的小学和中学学生分发各种STEM套件,参加校园现有的K-12公共外展活动。此外,该奖项反映了NSF的法定任务,并通过基金会的知识分子优点和更广泛的影响评估标准来反映NSF的法定任务。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Naomi Chesler其他文献
Improvement in pulmonary hypertension discrimination using multiple MRA pant-leg parameters of pulmonary artery
- DOI:
10.1186/1532-429x-16-s1-o73 - 发表时间:
2014-01-16 - 期刊:
- 影响因子:
- 作者:
Phillip Kilgas;Eric M Schrauben;Alejandro Roldán-Alzate;Naomi Chesler;Oliver Wieben;Christopher J Francois;Mark L Schiebler - 通讯作者:
Mark L Schiebler
In-vivo and Ex-vivo Characterization of Estrogen Receptor α (ERα)-Mediated Effects on the Pulmonary Vasculature in PH
- DOI:
10.1016/j.jamcollsurg.2021.07.063 - 发表时间:
2021-11-01 - 期刊:
- 影响因子:
- 作者:
Betty J. Allen;Rasika Ramanathan;Hailey Frye;Timothy A. Hacker;Tim Lahm;Naomi Chesler - 通讯作者:
Naomi Chesler
Naomi Chesler的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Naomi Chesler', 18)}}的其他基金
TUES-Type 2: First-year Virtual Internships to Increase Persistence of Underrepresented Groups in Engineering: RescuShell and its Parent Company RescuTek
TUES-Type 2:第一年虚拟实习,以提高工程领域代表性不足群体的持久性:RescuShell 及其母公司 RescuTek
- 批准号:
1225885 - 财政年份:2012
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
CAREER: Vascular Gene Therapy: Characterization and Optimization
职业:血管基因治疗:表征和优化
- 批准号:
0234007 - 财政年份:2002
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
CAREER: Vascular Gene Therapy: Characterization and Optimization
职业:血管基因治疗:表征和优化
- 批准号:
9985012 - 财政年份:2000
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
Summer Institute in Japan for U.S. Graduate Students in Science and Engineering
美国科学与工程研究生日本暑期学院
- 批准号:
9213261 - 财政年份:1992
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
相似国自然基金
支持可适应设计的开放式架构产品更改传播及其稳健性研究
- 批准号:52265031
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
复杂产品并行设计多源变更传播机理和路径优化方法研究
- 批准号:51505254
- 批准年份:2015
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
基于多域可供性的复杂产品布局再设计方法研究
- 批准号:51405247
- 批准年份:2014
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
软件更改缺陷实时预测方法研究
- 批准号:61402355
- 批准年份:2014
- 资助金额:27.0 万元
- 项目类别:青年科学基金项目
可变性设计动态响应与更改传播原理研究及应用
- 批准号:51205349
- 批准年份:2012
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
相似海外基金
LTREB: Collaborative Research: Long-term changes in peatland C fluxes and the interactive role of altered hydrology, vegetation, and redox supply in a changing climate
LTREB:合作研究:泥炭地碳通量的长期变化以及气候变化中水文、植被和氧化还原供应变化的相互作用
- 批准号:
2411998 - 财政年份:2024
- 资助金额:
$ 8.34万 - 项目类别:
Continuing Grant
Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
- 批准号:
2244994 - 财政年份:2023
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
Collaborative Research: Determining climate related changes in water mass structure, paleoventilation, and paleocirculation in the Southeast Indian and Southern Oceans
合作研究:确定东南印度洋和南大洋与气候相关的水团结构、古通风和古环流变化
- 批准号:
2231146 - 财政年份:2023
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
Collaborative Research: Spatio-temporal changes in Red Sea surface hydrology and controls on deep ocean circulation since the 1700s
合作研究:1700年代以来红海表面水文学的时空变化及其对深海环流的控制
- 批准号:
2303245 - 财政年份:2023
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant
Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
- 批准号:
2244995 - 财政年份:2023
- 资助金额:
$ 8.34万 - 项目类别:
Standard Grant